Yonsei Med J.  2002 Jun;43(3):341-345. 10.3349/ymj.2002.43.3.341.

Effect of Intracavitary Injection of Urokinase in the Experimentally Induced Early Pyogenic Liver Abscess of the Rabbit

Affiliations
  • 1Department of Surgery, Ansan Hospital, Korea University College of Medicine, Korea.
  • 2Department of Diagnostic Radiology, Ansan Hospital, Korea University College of Medicine, Korea. sahcha@ kumc.or.kr
  • 3Department of Diagnostic Radiology, Guro Hospital, Korea University College of Medicine, Korea.
  • 4Department of Diagnostic Radiology, Anam Hospital, Korea University College of Medicine, Korea.
  • 5Department of Anesthesiology, Guro Hospital, Korea University College of Medicine, Seoul, Korea.
  • 6Department of Pathology, Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
  • 7Department of Occupational and Environmental Medicine, Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
  • 8Department of Surgery, Guro Hospital, Korea University College of Medicine, Korea.
  • 9Department of Surgery, Anam Hospital, Korea University College of Medicine, Korea.
  • 10Breast Cancer Clinic, National Cancer Center, Koyang, Korea.

Abstract

This study was carried out to assess the effects of intracavitary injection of urokinase in the early liver abscess (ELA) of the rabbits. ELAs were induced on 25 in 47 New Zealand rabbits, which were divided into two groups, with 15 in group A, and 10 in group B. Urokinase was injected into the ELA of group A, and normal physiologic saline into those of group B. One and a half hours after the injections, the rabbits were sacrificed and evaluated by pathologists for the degree of fibrosis of the ELA wall, and fibrinolysis in the ELA itself. Statistical analyses were performed between the two groups. The following ELA sizes for each group were obtained: Group A, 4.3 X 2.9-10.1 X 7.2 mm (mean 7.1 X 4.1 mm); Group B, 4.6 X 2.7-15.0 X 9.7 mm (mean 8.5 X 4.57 mm). Eleven (73%) in group A showed grade II fibrosis of ELA wall, and 8 (80%) in group B showed grade III fibrosis of ELA wall (p=0.002). On pathological analysis, 5 (46%) in group A showed grade II fibrin, and 8 (80%) in group B showed grade III fibrin, of the ELA (p=0.09). In conclusion, injection of urokinase, into the ELAs, can reduce the degree of fibrosis of abscess walls.

Keyword

Liver; liver abscess; urokinase

MeSH Terms

Animal
Fibrinolytic Agents/*administration & dosage/therapeutic use
Fibrosis
Injections
Liver Abscess/*drug therapy/pathology
Rabbits
Support, Non-U.S. Gov't
Suppuration
Urinary Plasminogen Activator/*administration & dosage/therapeutic use
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