J Vet Sci.  2006 Mar;7(1):97-99. 10.4142/jvs.2006.7.1.97.

Epitheliotropic cutaneous lymphoma (mycosis fungoides) in a dog

• Bhang DH
• Choi US
• Kim MK
• Choi EH
• kang MS
• Hwang CY
• Kim DY
• Youn HY
• Lee CW

• KMID: 1103565
• DOI: http://doi.org/10.4142/jvs.2006.7.1.97

Abstract

A seven-year-old castrated male Yorkshire terrier dog was presented for a recurrent skin disease. Erythematous skin during the first visit progressed from multiple plaques to patch lesions and exudative erosion in the oral mucosa membrane. Biopsy samples were taken from erythematous skin and were diagnosed with epitheliotropic T cell cutaneous lymphoma by histopathology and immunochemical stain. In serum chemistry, the dog had a hypercalcemia (15.7 mg/dl) and mild increased alkaline phosphatase (417 U/l). Immunohistochemistry was performed to detect parathyroid hormone-related peptide (PTH-rP) in epitheliotropic cutaneous lymphoma tissues but the neoplastic cells were not labeled with anti-PTH-rP antibodies. The patient was treated with prednisolone and isotretinoin. However, the dog died unexpectedly.

Keyword

dog; epitheliotropic cutaneous lymphoma; hypercalcemia; mycosis fungoides; PTH-rP

MeSH Terms

Animals
Dog Diseases/drug therapy/*pathology
Dogs
Fatal Outcome
Isotretinoin/therapeutic use
Male
Mycosis Fungoides/drug therapy/pathology/*veterinary
Prednisolone/therapeutic use
Skin Neoplasms/drug therapy/pathology/*veterinary

Figure

• 

  Fig. 1 Generalized distribution of raised plaque overlying scale in abdomen.

• 

  Fig. 2 Hyperemia, tissue proliferation, erosion, and ulcer in the oral mucosal membrane with crusts and exudates.

• 

  Fig. 3 Aspirate smear of the plaque. Predominant cells are medium to large lymphocytes with varying amounts of weakly basophilic cytoplasm resembling histiocytes. Chromatin is fine and nucleoli are indistinct. Wright stain, ×40.

• 

  Fig. 4 Note intraepidermal and follicular infiltration of lymphoid cells (arrow). H&E stain, ×120.

• 

  Fig. 5 Intraepidermis tumor, Note strong positive tumor cells for CD3. Avdin-biotin-peroxidase complex method, Mayer's hematoxylin counterstain, ×400.

Reference

1. Brown NO, Nesbitt GH, Patnaik AK, Gregory MacEwen E. Cutaneous lymphosarcoma in the dog: A disease with variable clinical and histologic manifestations. J Am Anim Hosp Assoc. 1980. 16:343–345.

2. Campbell KL. . Small Animal Dermatology Secrets. 2004. Philadelphia: Hanley & Belfus;435–440.

3. Choi US, Jeong SM, Kang MS, Jung IS, Kim DY, Lee CW. Cutaneous lymphoma in a juvenile dog. Vet Clin Pathol. 2004. 33:47–49.

4. Donaldson D, Day MJ. Epitheliotropic lymphoma (mycosis fungoides) presenting as blepharoconjunctivitis in an Irish setter. J Small Anim Pract. 2000. 41:317–320.

5. Foster AP, Evans E, Kerlin RL, Vail DM. Cutaneous T-Cell lymphoma with Sezary syndrome in a dog. Vet Clin Pathol. 1997. 26:188–192.

6. Gregory MacEwen E, Withrow SJ. Small Animal Clinical Oncology. 2001. 3rd ed. Philadelphia: Saunders;38–39. 558

7. McKeever PJ, Grindem CB, Stevens JB. Canine cutaneous lymphoma. J Am Vet Med Assoc. 1982. 180:531–536.

8. Morrison WB. Cancer in Dogs and Cats. 2002. 2nd ed. Jackson: Teton Newmedia;643663–665.

9. Obagi S, DeRubertis F, BrownMPA-C L, Deng JS. Hypercalcemia and parathyroid hormone related protein expression in cutaneous T-cell lymphoma. Int J Dermatol. 1999. 38:855–862.

10. Scott DW, Miller WH, Griffin CE. Muller & Kirk's Small Animal Dermatology. 2001. 6th ed. Philadelphia: Sanunders;1333–1338.

11. Thrall MA, Macy DW, Snyder SP, Hall RL. Cutaneous lymphosarcoma and leukemia in a dog resembling Sezary syndrome in man. Vet Pathol. 1984. 21:182–186.

12. White SD, Rosychuk RAW, Scott KV, Trettien AL, Jonas L, Denerolle P. Use of isotretinoin and etretinate for the treatment of benign cutaneous neoplasia and cutaneous lymphoma in dogs. J Am Vet Med Assoc. 1993. 202:387–391.