J Vet Sci.
2002 Dec;3(4):343-349.
The Antinociceptive and Anti-inflammatory Effect of Ethylacetate Extracts from Bang-Poong (Radix ledebouriellae) on the Freund's Adjuvant-Induced Arthritis in Rats
- Affiliations
-
- 1Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon, South Korea. JHL1101@snu.ac.kr
- 2Hormone Research Center, College of Veterinary Medicine, Chonnam National University, Kwang-ju, South Korea.
- 3Department of Acupuncture and Moxibustion, College of Oriental Medicine, Kyung-Hee University, Seoul, South Korea.
- 4Natural Products Research Institute, Seoul National University, Seoul, South Korea.
- 5Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul, MN, 55108, USA.
Abstract
- In this study, we aimed to determine the antinociceptive and/or anti-inflammatory effect of Bang-Poong (BP, Radix Ledebouriellae) on Freund's adjuvant-induced arthritis in rats. Traditionally, BP has been used to treat several inflammatory diseases such as arthritis. Whole BP is extracted into two fractions that were ethylacetate and hexane-soluble fractions. Adult Sprague-Dawley rats (n=30, 130-150 g) were subcutaneously administered by the Freund's complete adjuvant (FCA) into the plantar surface of right hindpaw. Twelve days after the injection of FCA, the rats initially showed typical inflammatory edema and arthritis-related symptoms on the contralateral side (i.e. left hindpaw). Both antinociceptive (evaluation of mechanical, thermal pain threshold and analysis of spinal Fos expression) and anti- inflammatory (evaluation of paw edema, serum interleukin-6 level and x-ray analysis) effect of BP extracts were examined. The ethylacetate fraction of BP (BPE) significantly suppressed the FCA-induced paw edema as well as the serum level of interleukin-6 and it alleviated the radiological changes. Moreover, both mechanical and thermal hyperalgesia were attenuated by the treatment of BPE. In addition, spinal Fos expression that was increased by FCA- injection was suppressed in BPE group. Therefore, this study showed that BPE produced significant both antinociceptive and anti-inflammatory effects on FCA- induced arthritis in rats, while hexane fraction of BP did not show these effects. In conclusion, it is suggested that the ethylacetate fraction of BP is recommended to alleviate the arthritis-related symptoms in human according to the results of this study.
MeSH Terms
-
Analgesics/*pharmacology
Animals
Anti-Inflammatory Agents/*pharmacology
Arthritis, Experimental/*drug therapy/radiography
Drugs, Chinese Herbal/*pharmacology
Edema/veterinary
Hindlimb/radiography
Hyperalgesia/veterinary
Interleukin-6/blood
Male
Pain Measurement/veterinary
*Phytotherapy
Plant Extracts/pharmacology
Proto-Oncogene Proteins c-fos/metabolism
Rats
Rats, Sprague-Dawley
Spinal Cord/metabolism
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