- Effects of DA-9701, a Novel Prokinetic Agent, on Phosphorylated Extracellular Signal-Regulated Kinase Expression in the Dorsal Root Ganglion and Spinal Cord Induced by Colorectal Distension in Rats
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Lee SP, Lee KN, Lee OY, Lee HL, Jun DW, Yoon BC, Choi HS, Hwang SJ, Lee SE
- KMID: 1774540
- Gut Liver.
- 2014 Mar;8(2):140-147.
BACKGROUND/AIMS: DA-9701, a standardized extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that exhibits an analgesic effect on the abdomen. We investigated whether DA-9701 affects visceral... -
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- Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression
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Wang YG, Kim SJ, Baek JH, Lee HW, Jeong SY, Chun KH
- KMID: 1383801
- Exp Mol Med.
- 2012 Jun;44(6):387-393.
Although mounting evidence indicates the involvement of galectin-3 in cancer progression and metastasis, the underlying molecular mechanisms remain largely unknown. In this study, we investigated the effect and possible mechanism... -
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- The Expression of Corticotropin-Releasing Factor in the Central Nucleus of the Amygdala, Induced by Colorectal Distension, is Attenuated by General Anesthesia
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Kim SH, Han JE, Hwang S, Oh DH
- KMID: 1779236
- J Korean Med Sci.
- 2010 Nov;25(11):1646-1651.
- doi: 10.3346/jkms.2010.25.11.1646
Corticotrophin-releasing factor (CRF), a key regulator of the hypothalamic-pituitary axis, is expressed in the central nucleus of the amygdala (CeA) and its expression is upregulated in stress-related disorders. We investigated... -
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- Ethyl Acetate Fraction from Cudrania Tricuspidata Inhibits IL-1beta-Stimulated Osteoclast Differentiation through Downregulation of MAPKs, c-Fos and NFATc1
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Lee EG, Yun HJ, Lee SI, Yoo WH
- KMID: 1785661
- Korean J Intern Med.
- 2010 Mar;25(1):93-100.
- doi: 10.3904/kjim.2010.25.1.93
BACKGROUND/AIMS: The present study was performed to determine the effects of the ethyl acetate extract of Cudrania tricuspidata (EACT) on interleukin (IL)-1beta-stimulated receptor activator of NF-kappaB ligand (RANKL)-mediated osteoclast differentiation.... -
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- Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway
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Won SM, Park YH, Kim HJ, Park KM, Lee WJ
- KMID: 1098087
- Exp Mol Med.
- 2006 Oct;38(5):525-534.
Catechins, components of green tea, reduce the incidence of cardiovascular diseases such as atherosclerosis. Angiotensin II (Ang II) is highly implicated in the proliferation of vascular smooth muscle cells (VSMC),... -
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- Role of gamma-aminobutyric acid B (GABA B) receptors in the regulation of kainic acid-induced cell death in mouse hippocampus
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Lee HK, Seo YJ, Choi SS, Kwon MS, Shim EJ, Lee JY, Suh HW
- KMID: 1116198
- Exp Mol Med.
- 2005 Dec;37(6):533-545.
Kainic acid (KA) is well-known as an excitatory, neurotoxic substance. In mice, KA administered intracerebroventricularly (i.c.v.) lead to morphological damage of hippocampus expecially concentrated on the CA3 pyramidal neurons. In... -
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- The Antinociceptive and Anti-inflammatory Effect of Ethylacetate Extracts from Bang-Poong (Radix ledebouriellae) on the Freund's Adjuvant-Induced Arthritis in Rats
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Kim HW, Kwon YB, Ham TW, Roh DH, Yoon SY, Han HJ, Kang SK, Lee HJ, Mar WC, Yang IS, Beitz AJ, Lee JH
- KMID: 1097352
- J Vet Sci.
- 2002 Dec;3(4):343-349.
In this study, we aimed to determine the antinociceptive and/or anti-inflammatory effect of Bang-Poong (BP, Radix Ledebouriellae) on Freund's adjuvant-induced arthritis in rats. Traditionally, BP has been used to treat... -
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