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Effects of DA-9701, a Novel Prokinetic Agent, on Phosphorylated Extracellular Signal-Regulated Kinase Expression in the Dorsal Root Ganglion and Spinal Cord Induced by Colorectal Distension in Rats

Lee SP, Lee KN, Lee OY, Lee HL, Jun DW, Yoon BC, Choi HS, Hwang SJ, Lee SE

  • KMID: 1774540
  • Gut Liver.
  • 2014 Mar;8(2):140-147.
BACKGROUND/AIMS: DA-9701, a standardized extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that exhibits an analgesic effect on the abdomen. We investigated whether DA-9701 affects visceral...
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Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression

Wang YG, Kim SJ, Baek JH, Lee HW, Jeong SY, Chun KH

  • KMID: 1383801
  • Exp Mol Med.
  • 2012 Jun;44(6):387-393.
Although mounting evidence indicates the involvement of galectin-3 in cancer progression and metastasis, the underlying molecular mechanisms remain largely unknown. In this study, we investigated the effect and possible mechanism...
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The Expression of Corticotropin-Releasing Factor in the Central Nucleus of the Amygdala, Induced by Colorectal Distension, is Attenuated by General Anesthesia

Kim SH, Han JE, Hwang S, Oh DH

Corticotrophin-releasing factor (CRF), a key regulator of the hypothalamic-pituitary axis, is expressed in the central nucleus of the amygdala (CeA) and its expression is upregulated in stress-related disorders. We investigated...
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Ethyl Acetate Fraction from Cudrania Tricuspidata Inhibits IL-1beta-Stimulated Osteoclast Differentiation through Downregulation of MAPKs, c-Fos and NFATc1

Lee EG, Yun HJ, Lee SI, Yoo WH

BACKGROUND/AIMS: The present study was performed to determine the effects of the ethyl acetate extract of Cudrania tricuspidata (EACT) on interleukin (IL)-1beta-stimulated receptor activator of NF-kappaB ligand (RANKL)-mediated osteoclast differentiation....
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Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway

Won SM, Park YH, Kim HJ, Park KM, Lee WJ

  • KMID: 1098087
  • Exp Mol Med.
  • 2006 Oct;38(5):525-534.
Catechins, components of green tea, reduce the incidence of cardiovascular diseases such as atherosclerosis. Angiotensin II (Ang II) is highly implicated in the proliferation of vascular smooth muscle cells (VSMC),...
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Role of gamma-aminobutyric acid B (GABA B) receptors in the regulation of kainic acid-induced cell death in mouse hippocampus

Lee HK, Seo YJ, Choi SS, Kwon MS, Shim EJ, Lee JY, Suh HW

  • KMID: 1116198
  • Exp Mol Med.
  • 2005 Dec;37(6):533-545.
Kainic acid (KA) is well-known as an excitatory, neurotoxic substance. In mice, KA administered intracerebroventricularly (i.c.v.) lead to morphological damage of hippocampus expecially concentrated on the CA3 pyramidal neurons. In...
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The Antinociceptive and Anti-inflammatory Effect of Ethylacetate Extracts from Bang-Poong (Radix ledebouriellae) on the Freund's Adjuvant-Induced Arthritis in Rats

Kim HW, Kwon YB, Ham TW, Roh DH, Yoon SY, Han HJ, Kang SK, Lee HJ, Mar WC, Yang IS, Beitz AJ, Lee JH

  • KMID: 1097352
  • J Vet Sci.
  • 2002 Dec;3(4):343-349.
In this study, we aimed to determine the antinociceptive and/or anti-inflammatory effect of Bang-Poong (BP, Radix Ledebouriellae) on Freund's adjuvant-induced arthritis in rats. Traditionally, BP has been used to treat...
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