J Korean Med Sci.  1997 Aug;12(4):364-368. 10.3346/jkms.1997.12.4.364.

Adult T-cell leukemia/lymphoma with features of CD30-positive anaplastic large cell lymphoma--a case report

• Lee SN
• Nam E
• Cha JH
• Kim MJ
• Koo H
• Kwon SW
• Park HJ
• Whang KK
• Hong SI

• KMID: 1081060
• DOI: http://doi.org/10.3346/jkms.1997.12.4.364

Abstract

We experienced a 58-year-old Korean man with adult T-cell leukemia/lymphoma with features of histologically anaplastic large cell lymphoma involving the skin and testis. The patient had cutaneous nodules in both extremities and a palpable right testicular mass. Right orchiectomy was performed and specimens of removed testicle and skin nodules showed immunohistologically anaplastic large cell lymphoma with T-cell phenotype, and CD30 antigen was positive. A human T-cell lymphotropic virus type 1 (HTLV-1) antibody titer was over 1 : 256 and integration of HTLV-1 proviral DNA pX gene was identified in the peripheral blood mononuclear cells and lymphoma tissue by polymerase chain reaction. Peripheral blood and bone marrow did not show any evidence of characteristic neoplastic T-cells.

MeSH Terms

Case Report
Diagnosis, Differential
HTLV-I/isolation & purification
Human
Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/diagnosis*
Lymphoma, Large-Cell, Ki-1/diagnosis*
Male
Middle Age
Skin Neoplasms/diagnosis*
Testicular Neoplasms/diagnosis*