J Korean Med Sci.  2001 Feb;16(1):69-74. 10.3346/jkms.2001.16.1.69.

Combination of oxaliplatin, fluorouracil, and leucovorin in the treatment of fluoropyrimidine-pretreated patients with metastatic colorectal cancer

• Lee JH
• Lee JH
• Kim TW
• Lee KH
• Kang YK
• Lee JS
• Kim SH
• Kim HC
• Yu CS
• Kim JC
• Kim WK

• KMID: 1066497
• DOI: http://doi.org/10.3346/jkms.2001.16.1.69

Abstract

There has been no standard therapy for patients with metastatic colorectal cancer who have failed to first-line fluorouracil-based treatment. The present study was designed to assess the efficacy and toxicities of a combination of oxaliplatin, 5-fluorouracil (5-FU) and leucovorin in fluoropyrimidine-pretreated patients with metastatic colorectal cancer. Chemotherapy consisted of oxaliplatin 85 mg/m2 on day 1, followed by leucovorin 20 mg/m2 and 5-FU 1,200 mg/m2 on days 1 and 2. Treatment courses were repeated every two weeks. Thirty-nine patients were enrolled in this study. All patients previously received fluoropyrimidine-based chemotherapy. Thirty-one patients were assessable for response and 33 for treatment toxicity. Six patients required dose reduction of 5-FU due to grade III/IV cytopenia. Nausea/vomiting and peripheral neuropathy were common non-hematologic toxicities. Overall response rate was 42.0% including 3 complete response and 10 partial response. The median response duration was 91 days (range, 28-224+). The median duration of progression-free survival was 132 days (range, 40-308). A combination of oxaliplatin, 5-FU, and leucovorin showed high response rate in fluoropyrimidine-pretreated patients with metastatic colorectal cancer, but the duration of response was relatively short. It may be worthwhile to explore its therapeutic potential in the first-line treatment setting.

Keyword

Colorectal Neoplasms; Oxaliplatin; Fluorouracil; Leucovorin

MeSH Terms

Adult
Aged
Antineoplastic Agents, Combined/therapeutic use*
Antineoplastic Agents, Combined/adverse effects
Colorectal Neoplasms/mortality
Colorectal Neoplasms/drug therapy*
Disease-Free Survival
Female
Fluorouracil/administration & dosage
Human
Leucovorin/administration & dosage
Male
Middle Age
Organoplatinum Compounds/administration & dosage