Korean J Gastroenterol.  2010 May;55(5):340-343. 10.4166/kjg.2010.55.5.340.

Interstitial Lung Disease Associated with Combination Chemotherapy of Oxaliplatin, 5-Fluorouracil, and Leucovorin

• Park S
• Jung JJ
• Kim GB
• Yoon HS
• Ko SH
• Ko JE
• Lee YS

• KMID: 1718341
• DOI: http://doi.org/10.4166/kjg.2010.55.5.340

Abstract

Oxaliplatin with 5-fluorouracil plus leucovorin (FOLFOX) has become the standard treatment in patients with colorectal cancer. Among known toxicities induced by oxaliplatin, hematological, gastrointestinal and neurological toxicities are common. However, acute pulmonary toxicity associated with oxaliplatin is unusual. One case of interstitial lung disease associated with the FOLFOX protocol is reported here.

Keyword

Oxaliplatin; Colon cancer; Interstitial lung diseases

MeSH Terms

Aged
Antineoplastic Agents/*adverse effects/therapeutic use
Antineoplastic Combined Chemotherapy Protocols
Colorectal Neoplasms/drug therapy
Fluorouracil/*adverse effects/therapeutic use
Humans
Leucovorin/*adverse effects/therapeutic use
Lung Diseases, Interstitial/chemically induced/*etiology/radiography
Male
Organoplatinum Compounds/*adverse effects/therapeutic use

Figure

• 

  Fig. 1. Chest x-ray. (A) On admission, chest x-ray showed lung without specific infiltration. (B) After 9 th cycle of chemotherapy, retic-ulonodular infiltration was observed on both lower lung field.

• 

  Fig. 2. Chest CT scan of both lower lung. (A) On admission, CT scan showed no specific infiltration. (B) After 9 th cycle of chemotherapy, reciculo- nodular pattern with ground-glass opacity and honeycomb change were observed.

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