Korean J Intern Med.  1997 Jan;12(1):80-83.

A case of coagulation factor V deficiency complicated with intracranial hemorrhage

• Yoon SG
• Cho ST
• Park SK
• Won JH
• Baick SH
• Hong DS
• Park HS

Abstract

Factor V deficiency is a relatively uncommon disorder, inherited as an autosomal recessive trait that manifests clinically only in individuals who inherit the defective gene from both parents. The hemorrhage of nasal and oral cavity and ecchymosis are common but intracranial hemorrhage is very rare. We experienced a 53 year old male patient with intracranial hemorrhage due to factor V deficiency. The laboratory tests showed prolongation of APTT and PT, normal bleeding time and normal thrombin time. The levels of the coagulation profiles on the patient revealed a significant decrease factor V, below 1% of normal range (60-140%). Other coagulation factors were normal. He was treated with fresh frozen plasma and completely recovered 3 weeks after treatment.

MeSH Terms

Cerebral Hemorrhage/therapy
Cerebral Hemorrhage/etiology*
Cerebral Hemorrhage/diagnosis
Disease-Free Survival
Factor V Deficiency/therapy
Factor V Deficiency/diagnosis
Factor V Deficiency/complications*
Human
Male
Middle Age
Plasma