- Molecular Features of Three Children Diagnosed With Early T-Cell Precursor Acute Lymphoblastic Leukemia
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Park D, Kim M, Kim Y, Han K, Lee JW
- KMID: 2373563
- Ann Lab Med.
- 2016 Jul;36(4):384-386.
- doi: 10.3343/alm.2016.36.4.384
No abstract available. -
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- Aryl Hydrocarbon Receptor Ligands Indoxyl 3-sulfate and Indole-3-carbinol Inhibit FMS-like Tyrosine Kinase 3 Ligand-induced Bone Marrow-derived plasmacytoid Dendritic Cell Differentiation
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Hwang WB, Kim DJ, Oh GS, Park JH
- KMID: 2424201
- Immune Netw.
- 2018 Oct;18(5):e35.
- doi: 10.4110/in.2018.18.e35
Aryl hydrocarbon receptor (AhR) regulates both innate and adaptive immune responses by sensing a variety of small synthetic and natural chemicals, which act as its ligands. AhR, which is expressed... -
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- Minor BCR-ABL1-Positive Acute Myeloid Leukemia Associated With the NPM1 Mutation and FLT3 Internal Tandem Duplication
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Kim MJ, Ahn S, Jeong SH, Jang JH, Han JH, Choi JR, Cho SR
- KMID: 2373538
- Ann Lab Med.
- 2016 May;36(3):263-265.
- doi: 10.3343/alm.2016.36.3.263
No abstract available. -
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- Differentiation induction of dendritic cell phenotypes from human leukemic cell lines
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Lee DH, Park JS, Eo WK, Kim WM, Kang K
- KMID: 1606842
- Korean J Physiol Pharmacol.
- 2001 Feb;5(1):79-86.
Recent clinical studies have shown that a high proportion of patients with acute promyelocytic leukemia (APL) achieve complete remission after treatment with all-trans retinoic acid (ATRA). However, most patients who receive continuous treatment... -
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- Prognostic Significance of FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype
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Lee JY, Joo YD, Oh SH, Shin JH, Kim HR, Lee SM, Lee JN
- KMID: 2252151
- Korean J Hematol.
- 2009 Jun;44(2):74-81.
- doi: 10.5045/kjh.2009.44.2.74
BACKGROUND: Activating mutations of the fms-like tyrosine kinase 3 gene (FLT3) by internal tandem duplication (ITD) in the juxtamembrane region are found in 20~30% of the adults with acute myeloid... -
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- Prognostic significance of the FLT3 ITD mutation in patients with normal-karyotype acute myeloid leukemia in relapse
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Park SH, Chi HS, Min SK, Cho YU, Jang S, Park CJ, Lee JH, Lee JH, Lee KH, Im HJ, Seo JJ
- KMID: 1782772
- Korean J Hematol.
- 2011 Jun;46(2):88-95.
- doi: 10.5045/kjh.2011.46.2.88
BACKGROUND: Fms-like tyrosine kinase 3 internal tandem duplication (FLT3 ITD) mutation is related to poor prognosis in normal-karyotype acute myeloid leukemia (AML). However, the prognostic significance of the mutation at... -
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- FLT3 Gene Mutations as a Prognostic Factor for Acute Myeloid Leukemia
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Chang SH, Lee NY, Kim DH, Sohn SK, Suh JS
- KMID: 2238828
- Korean J Lab Med.
- 2006 Aug;26(4):233-240.
- doi: 10.3343/kjlm.2006.26.4.233
BACKGROUND: Two distinct types of fms-like tyrosine kinase 3 (FLT3) gene mutations have been identified in acute myeloid leukemia (AML): D835 and internal tandem duplication (ITD) mutations. These mutations are... -
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- Prevalence of FLT3 Internal Tandem Duplication in Adult Acute Myelogenous Leukemia
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Lee JN, Kim HR, Shin JH, Joo YD
- KMID: 1781490
- Korean J Lab Med.
- 2007 Aug;27(4):237-243.
- doi: 10.3343/kjlm.2007.27.4.237
BACKGROUND: fms-like tyrosine kinase (FLT3), a member of the class III receptor tyrosine kinases, regulates the proliferation and differentiation of hematopoietic stem cells. An internal tandem duplication of the... -
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- Prognostic significance of nucleophosmin mutations and FLT3 internal tandem duplication in adult patients with cytogenetically normal acute myeloid leukemia
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Kim YK, Kim HN, Lee SR, Ahn JS, Yang DH, Lee JJ, Lee IK, Shin MG, Kim HJ
- KMID: 2252083
- Korean J Hematol.
- 2010 Mar;45(1):36-45.
- doi: 10.5045/kjh.2010.45.1.36
BACKGROUND: Nucleophosmin (NPM1) gene and fms-like tyrosine kinase 3 gene-internal tandem duplication (FLT3-ITD) mutations are the most frequent mutations in patients with cytogenetically normal (CN)-AML. We analyzed the prognostic impact... -
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- EGF Induced RET Inhibitor Resistance in CCDC6-RET Lung Cancer Cells
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Chang H, Sung JH, Moon SU, Kim HS, Kim JW, Lee JS
- KMID: 2374183
- Yonsei Med J.
- 2017 Jan;58(1):9-18.
- doi: 10.3349/ymj.2017.58.1.9
PURPOSE: Rearrangement of the proto-oncogene rearranged during transfection (RET) has been newly identified potential driver mutation in lung adenocarcinoma. Clinically available tyrosine kinase inhibitors (TKIs) target RET kinase activity, which... -
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- Annual Report on External Quality Assessment in Diagnostic Genetics in Korea (2009)
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Kim SH, Ki CS, Kim S, Kwon MJ, Kim JW, Park SS, Kim JS, Lee YK, Kong SY, Ki SJ, Han SH, Seo EJ, CHo HC, Kim EJ, Kim PW
- KMID: 2200555
- J Lab Med Qual Assur.
- 2010 Jun;32(1):147-170.
BACKGROUND: The quality control for genetic tests would be of great importance as the test volume and clinical demands increase dramatically. Diagnostic genetics subcommittee of KSQACL performed two trials for... -
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- Annual Report on the External Quality Assessment of Diagnostic Genetics in Korea (2015)
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Kim HY, Park CH, Lee SJ, Cho SI, Seong MW, Park SS, Kim SH, Diagnostic Genetics Subcommittee, Korean Association of External Quality Assessment Service
- KMID: 2162120
- J Lab Med Qual Assur.
- 2016 Mar;38(1):22-42.
- doi: 10.15263/jlmqa.2016.38.1.22
The Diagnostic Genetics Subcommittee of Korean Association of External Quality Assessment Service conducted two trials in 2015 based on cytogenetics and molecular genetics surveys. A total of 43 laboratories participated... -
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- Annual Report on the External Quality Assessment Scheme for Diagnostic Genetics in Korea (2014)
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Park CH, Shin SY, Park H, Cho SI, Seong MW, Park SS, Kim SH, Diagnostic Genetics Subcommittee, The Korean Association of External Quality Assessment Service
- KMID: 2200370
- J Lab Med Qual Assur.
- 2015 Jun;37(2):64-83.
- doi: 10.15263/jlmqa.2015.37.2.64
Quality control for genetic tests has become more important as testing volume and clinical demands have increased dramatically. The diagnostic genetics subcommittee of Korean Association of External Quality Assessment Service... -
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- N-ras Mutation Detection by Pyrosequencing in Adult Patients with Acute Myeloid Leukemia at a Single Institution
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Jeong JH, Park SH, Park MJ, Kim MJ, Kim KH, Park PW, Seo YH, Lee JH, Park J, Hong J, Ahn JY
- KMID: 1781320
- Ann Lab Med.
- 2013 May;33(3):159-166.
- doi: 10.3343/alm.2013.33.3.159
BACKGROUND: N-ras mutations are one of the most commonly detected abnormalities of myeloid origin. N-ras mutations result in a constitutively active N-ras protein that induces uncontrolled cell proliferation and inhibits... -
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- Correlation of NPM1 Type A Mutation Burden With Clinical Status and Outcomes in Acute Myeloid Leukemia Patients With Mutated NPM1 Type A
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Jo SY, Park SH, Kim IS, Yi J, Kim HH, Chang CL, Lee EY, Cho YU, Jang S, Park CJ, Chi HS
- KMID: 2373568
- Ann Lab Med.
- 2016 Sep;36(5):399-404.
- doi: 10.3343/alm.2016.36.5.399
BACKGROUND: Nucleophosmin gene (NPM1) mutation may be a good molecular marker for assessing the clinical status and predicting the outcomes in AML patients. We evaluated the applicability of NPM1 type... -
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- Low Frequency and Variability of FLT3 Mutations in Korean Patients with Acute Myeloid Leukemia
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Bang SM, Ahn JY, Park J, Park SH, Park J, Cho EK, Shin DB, Lee JH, Yoo SJ, Jeon IS, Kim YK, Kim HJ, Kim HN, Lee IK, Kang HJ, Shin HY, Ahn HS
- KMID: 1783069
- J Korean Med Sci.
- 2008 Oct;23(5):833-837.
- doi: 10.3346/jkms.2008.23.5.833
FLT3 mutations are common genetic changes, and are reported to have prognostic significance in acute myeloid leukemia (AML). The FLT3 internal tandem duplication (ITD) and the D835 activating mutation in... -
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