- Bcl-xL Protein Expression in Gastric Adenoma and Adenocarcinoma
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Lee DS, Lee GM, An BM, Lee EH, Han SW, Jung IS, Park DH
- KMID: 1572037
- Korean J Gastroenterol.
- 2000 Dec;36(6):745-751.
No Abstract Available. -
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- The Expression of the Bcl-2 Family Proteins in Thyroid Neoplasms
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Ahn IM, Kim ES, Hong SJ, Gong KY, Lee TJ, Kim JY, Kim SB, Kim SH
- KMID: 2331109
- J Korean Soc Endocrinol.
- 1998 Sep;13(3):359-365.
BACKGROUND: Proteins of the Bcl-2 family are intracellular membrane-associated proteins that regulate programmed cell death either positively or negatively by as yet unknown mechanism. Bcl-2 family proteins have an antiapoptotic... -
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- Function of bcl-X proteins in Nitric Oxide-induced Apoptosis in RAW 264.7 Macrophages
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Paik SG, Kim YS, Im JY, Yoon JH
- KMID: 1550772
- Korean J Immunol.
- 1999 Sep;21(3):229-236.
LPS and IFN-r induce nitric oxide synthase in macrophages and the resultant NO causes apoptotic cell death in the activated macrophages. NO production and apoptosis were inhibited by N-monomethyl L-arginine... -
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- Apoptosis of Prostate Cancer by Inhibition of Bcl-xL Expression
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Kwak C, Jeong H, Kim JH, Lee ES, Lee SE
- KMID: 2293491
- Korean J Urol.
- 2004 May;45(5):463-471.
PURPOSE: In this study, we evaluated in vitro whether the anti-sense transfection that was targeted against Bcl-xL would induce cytotoxicity via apoptosis in prostate cancer cells. MATERIALS AND METHODS: cDNA of... -
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- Immunohistochemical Expression of Bcl-2, Bcl-xL, Bax, p53 Proteins in Gastric Adenoma and Adenocarcinoma
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Lee DS, Kang SB, Baek JT, Nam SW, Lee KM, Ahn BM, Lee EH, Han SW, Chung IS
- KMID: 772786
- Korean J Gastroenterol.
- 2005 Jun;45(6):394-400.
BACKGROUND/AIMS: The aim of this study was to investigate the immunohistochemical expression of bcl-2, bcl-xL, bax, and p53 proteins according to the pathological parameters such as grade of dysplasia,... -
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- Mechanism of FHIT-Induced Apoptosis in Lung Cancer Cell Lines
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Yoo JS, Kim CH
- KMID: 2132973
- Tuberc Respir Dis.
- 2004 May;56(5):450-464.
- doi: 10.4046/trd.2004.56.5.450
BACKGROUND: The FHIT (fragile histidine triad) gene is a frequent target of deletions associated with abnormal RNA and protein expression in lung cancer. Previous studies have shown FHIT gene transfer... -
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- Fluoxetine Up-Regulates Bcl-xL Expression in Rat C6 Glioma Cells
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Choi MR, Oh DH, Kim SH, Yang BH, Lee JS, Choi J, Jeon HS, Chai YG, Park YC
- KMID: 2316048
- Psychiatry Investig.
- 2011 Jun;8(2):161-168.
OBJECTIVE: To analyze both differentially expressed genes and the Bcl-xL protein expression after acute and chronic treatment with fluoxetine in rat C6 glioma cells. METHODS: C6 glioma cells were cultured for... -
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- Apoptosis of Prostate Cancer by Bax Gene Expression
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Kwak C, Jin RJ, Ku JH, Jeong H, Lee ES, Lee SE, Lee CW
- KMID: 2293555
- Korean J Urol.
- 2003 Sep;44(9):916-923.
PURPOSE: To evaluate the antitumor effect of the proapoptotic Bax gene in prostate cancer cells, in vitro, using a plasmid vector expressing the human Bax gene. MATERIALS AND METHODS: cDNA of... -
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- Induction of Apoptosis of Bladder Cancer Cells by Zinc-Citrate Compound
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Hong SH, Choi YS, Cho HJ, Lee JY, Hwang TK, Kim SW
- KMID: 2316135
- Korean J Urol.
- 2012 Nov;53(11):800-806.
PURPOSE: Zinc is one of the trace minerals in the body and is known to have an anticancer effect by inducing apoptosis in prostate cancer. We aimed to investigate the... -
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- The Protein Expressions of Apoptosis-associated Genes in the Obstructed Ureters of Rats
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Kim HG, Paick SH, Lho YS, Kim HH, Kwak C
- KMID: 2294200
- Korean J Urol.
- 2006 Feb;47(2):189-194.
- doi: 10.4111/kju.2006.47.2.189
PURPOSE: The role of apoptosis in the pathogenesis of ureteral damage from obstructive uropathy has rarely been studied. This study was performed to determine the protein expression of the apoptosis-associated... -
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- Effects of Sevoflurane and Ischemic Preconditioning on Neurologic Injury and Bcl-2 Family Protein mRNA Expression after Transient Spinal Ischemia in the Rats
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Kang SH, Kim ES, Baek SH, Kwon JY
- KMID: 2228546
- Korean J Crit Care Med.
- 2004 Jun;19(1):20-31.
BACKGROUND: Spinal cord injury occurring as the result of surgical repair of thoracic and thoracoabdominal aortic disease remains a devastating complication. Anesthetic and ischemic preconditioning have been known to prevent... -
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- Induction of the Intrinsic Apoptotic Pathway by 3-Deazaadenosine Is Mediated by BAX Activation in HL-60 Cells
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Lee SY, Ko KW, Kang WK, Choe YJ, Kim YH, Kim IK, Kim J, Kim HS
- KMID: 2071713
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):407-412.
- doi: 10.4196/kjpp.2010.14.6.407
3-Deazaadenosine (DZA), a potent inhibitor of S-adenosylhomocysteine hydrolase, was previously proposed to induce intrinsic apoptosis in human leukemic cells. In the present study, we analyzed the mechanism underlying the DZA-induced... -
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- Antiproliferative and Apoptotic Effects of Zinc-Citrate Compound (CIZAR(R)) on Human Epithelial Ovarian Cancer Cell (OVCAR3)
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Lee YS, Kim JD, Park LO, Bae SN
- KMID: 2272841
- Korean J Obstet Gynecol.
- 2006 Jul;49(7):1427-1436.
OBJECTIVE: Human seminal plasma has diverse biological activities including cytotoxic effect. It contains high concentrations of zinc and citric acid. Zinc inhibits several carcinoma cell growths through induction of cell... -
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- Inhibition of gamma ray-induced apoptosis by stimulatory heterotrimeric GTP binding protein involves Bcl-xL down-regulation in SH-SY5Y human neuroblastoma cells
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Kim SY, Seo M, Oh JM, Cho EA, Juhnn YS
- KMID: 1090961
- Exp Mol Med.
- 2007 Oct;39(5):583-593.
Heterotrimeric GTP-binding proteins (G proteins) transduce extracellular signals into intracellular signals by activating effector molecules including adenylate cyclases that catalyze cAMP formation, and thus regulate various cellular responses such as... -
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- A Study on the Effects of Anticarcinogenic Activity of Chondria Crassicaulis
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Jeon KH, Shin MO, Bae SJ
- KMID: 2269894
- Korean J Nutr.
- 2005 Sep;38(7):503-511.
In this study, we investigated the biological activity of Chondria crassicaulis (CC) on the human cancer cells. CC was extracted with methanol and further fractionated into four diffferent types: hexane... -
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- Analysis of in vitro apoptosis induced by virulent Korean isolate of classical swine fever virus in peripheral blood B cell line
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Kim SM, Lim SI, Song JY, Hyun BH
- KMID: 1431986
- Korean J Vet Res.
- 2012 Dec;52(4):259-262.
Classical swine fever (CSF) is a highly contagious disease among swine that has an important economic impact on worldwide. One clinical symptom of CSF is leukopenia, in particular lymphopenia, which... -
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- Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-X(L) involved in cardiotoxin III-induced apoptosis in K562 cells
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Yang SH, Chien CM, Lu MC, Lin YH, Hu XW, Lin SR
- KMID: 1110128
- Exp Mol Med.
- 2006 Aug;38(4):435-444.
Cardiotoxin III (CTX III), a basic polypeptide with 60 amino acid residues isolated from Naja naja atra venom, has been reported to have anticancer activity. CTX III-induced K562 cell apoptosis... -
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- Endothelin A Receptor Blockade Influences Apoptosis and Cellular Proliferation in the Developing Rat Kidney
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Yoo KH, Yim HE, Jang GY, Bae IS, Choi BM, Hong YS, Lee JW
- KMID: 1794420
- J Korean Med Sci.
- 2009 Feb;24(1):138-145.
- doi: 10.3346/jkms.2009.24.1.138
Endothelin systems are believed to play important roles in the emergence and maintenance of functions of various organs during perinatal development, including the kidney. The present study was designed to... -
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- Knockdown of Bcl-xL Enhances Growth-Inhibiting and Apoptosis-Inducing Effects of Resveratrol and Clofarabine in Malignant Mesothelioma H-2452 Cells
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Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH
- KMID: 2069926
- J Korean Med Sci.
- 2014 Nov;29(11):1464-1472.
- doi: 10.3346/jkms.2014.29.11.1464
Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition... -
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- Effects of Endothelin A Receptor Antagonist to Cellular Proliferation and Apoptosis in Neonatal Rat Heart
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Choi BM, Yoo KH, Hong YS, Lee JW, Kim SK
- KMID: 2335742
- J Korean Pediatr Soc.
- 2003 Jul;46(7):668-678.
PURPOSE: In order to investigate the role of endothelins in the cardiac development, the present study was designed to examine the effects of endothelin A receptor(ETAR) antagonist to the cellular... -
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