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Superoxide Dismutase 1 Inhibits Alpha-Melanocyte Stimulating Hormone and Ultraviolet B-Induced Melanogenesis in Murine Skin

Oh CT, Lee D, Koo K, Lee J, Yoon HS, Choi YM, Kwon TR, Kim BJ

BACKGROUND: Over the last decade, the incidence of ultraviolet B (UVB)-related skin problems has increased. Oxidative stress caused by UVB induces the secretion of melanocyte growth and activating factors from...
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Development of intestinal ischemia/reperfusion-induced acute kidney injury in rats with or without chronic kidney disease: Cytokine/chemokine response and effect of alpha-melanocyte-stimulating hormone

Skottx M, Norregaard R, Birke-Sorensen H, Palmfeldt , Kwon TH, Jonassen T, Frokiaer J, Nielsen S

  • KMID: 2224271
  • Kidney Res Clin Pract.
  • 2014 Jun;33(2):79-88.
BACKGROUND: The primary aim of the study was to investigate the cytokine/chemokine response in the kidney, lung, and liver following acute kidney injury (AKI). The secondary aim was to test...
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Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin

Lee TH, Seo JO, Baek SH, Kim SY

  • KMID: 2048328
  • Biomol Ther.
  • 2014 Jan;22(1):35-40.
Resveratrol is a polyphenolic compound found in various natural products such as grapes and berries and possesses anti-cancer, anti-hyperlipidemia, and anti-aging properties. Recently, it has been reported that resveratrol inhibits...
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Induction of Melanogenesis by Rapamycin in Human MNT-1 Melanoma Cells

Hah YS, Cho HY, Lim TY, Park DH, Kim HM, Yoon J, Kim JG, Kim CY, Yoon TJ

  • KMID: 2434679
  • Ann Dermatol.
  • 2012 May;24(2):151-157.
BACKGROUND: Melanogenesis is one of the characteristic parameters of differentiation in melanocytes and melanoma cells. Specific inhibitors of phosphatidylinositol 3-kinase (PI3K), such as wortmannin and LY294002, stimulate melanin production in...
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Effect of xanthohumol on melanogenesis in B16 melanoma cells

Koo JH, Kim HT, Yoon HY, Kwon KB, Choi IW, Jung SH, Kim HU, Park BH, Park JW

Xanthohumol (XH), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), dose-dependently inhibited isobutylmethylxanthine (IBMX)-induced melanogenesis in B16 melanoma cells, with little cytotoxicity at the effective concentrations. Decreased melanin...
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The Effect of alpha-Melanocyte Stimulating Hormone on Renal Ischemia Reperfusion Injury

Yom CK, Jin JW, Chung KY, Sung SH, Han KW, Kang ES, Kim YS

  • KMID: 2003580
  • J Korean Soc Transplant.
  • 2006 Jun;20(1):49-54.
PURPOSE: In ischemia-reperfusion induced renal injuries, cytokines, chemoattractant chemokines, adhesion molecules and nitric oxide play an important role. alpha-Melanocyte stimulating hormone (alpha-MSH) is a potent anti-inflammatory cytokine so the therapeutic...
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Alpha-Melanocyte Stimulating Hormone Protects Pancreatic Islet Dysfunction by Peripheral Blood Mononuclear Cells in vitro

Jung EJ, Han DJ, Chang SH, Lim DG, Wee YM, Kim JH, Kim YH, Koo SK, Choi M, Park KT, Kim SC

  • KMID: 2003579
  • J Korean Soc Transplant.
  • 2006 Jun;20(1):41-48.
PURPOSE: The alpha-melanocyte-stimulating hormone (alpha-MSH) has been shown to interact with various cells of the immune and inflammatory system and down-regulate either the production or the action of the pro-inflammatory...
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Expression of Human Melanocyte Markers in PMA-containing Medium and Physiologic Mitogen-containing Medium

Yoon TJ, Kim KT, Kim KH, Lee JW, Lee MH

  • KMID: 2248994
  • Korean J Dermatol.
  • 2006 May;44(5):579-585.
BACKGROUND: There are many growth media for cultivation of human melanocytes (MGM), depending on the supplements added, and the growth of cells is closely related to these components. To understand...
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The Effect of alpha-MSH on Long-term Histologic Changes after Acute Ischemic Kidney Injury in Rats

Lee SY, Cho WY, Kim HK, Won NH

  • KMID: 2079443
  • Korean J Nephrol.
  • 2005 Mar;24(2):191-203.
BACKGROUND: Ischemic acute renal failure (ARF) is increasingly recognized as involving chronic functional and structural sequelae. Ischemia reperfusion injury (I/R) plays a major role in delayed graft function and long-term...
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Drug Induced Cerebral Proerectile Effect in Anesthethetized Rats

Park HJ, Nam JK, Park NC

  • KMID: 2298601
  • Korean J Androl.
  • 2004 Dec;22(3):132-140.
PURPOSE: To examine the centrally elicited erectile effects of alpha-MSH, oxytocin, prostagladin E1, and anabolic steroids after intracerebroventricular administration. MATERIALS AND METHODS: We used anesthetized male Sprague-Dawley rats. After intracerebroventricular...
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Effects of Intracerebroventricular Infusion of MTII in Monosodium Glutamate(MSG)-obese Rats

Kwon OJ, Choi DW, Huh JY, Bae JJ, Kim JH, Park YK, Kim JY, Kim YW

  • KMID: 2323282
  • J Korean Soc Study Obes.
  • 2004 Jun;13(2):101-109.
BACKGROUND: Leptin, secreted by adipose tissue, is an afferent signal molecule that contributes to body fat homeostasis through regulation of both food intake and energy expenditure. These effects are mediated...
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The Expression of the alpha-Melanocyte Stimulating Hormone (alpha-MSH) and Melanocortin-1 Receptor (MC1R) in the Epidermis of the Vitiligo

Cha YC, Lee HJ, Lee SJ, Na GY, Chung SL

  • KMID: 2302963
  • Korean J Dermatol.
  • 2003 Jun;41(6):690-695.
BACKGROUND: Vitiligo is a skin disease that is characterized by the loss of cutaneous pigmentation. alpha-Melanocyte stimulating hormone (alpha-MSH) is a neuroimmunomodulating peptide derived from proopiomelanocortin, and melanocortin-1 receptor (MC1R)...
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The Effect of alpha-MSH on Tumor Necrosis Factor-alpha and NFkappaB Activation in Cultured Human Proximal Tubular Cells during Simulated Ischemia

Lee SY, Kim SW, Jo SK, Kwon YJ, Cha DR, Cho WY, Kim HK

  • KMID: 2079271
  • Korean J Nephrol.
  • 2003 Jan;22(1):43-52.
BACKGROUND: Tumor necrosis factor a (TNF), potent proinflammatory cytokine, may be related with ischemia/reperfusion injury induced tubular cell inflammation and apoptosis. We examined TNF and its major nuclear transcriptional factor,...
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Altered Expression of Renal AQP1, AQP2 and NHE3 in Puromycin Aminonucleoside Induced Nephrotic Syndrome: Intervention by Alpha-MSH Treatment

Kwon TH, Kim KK

  • KMID: 2079268
  • Korean J Nephrol.
  • 2003 Jan;22(1):10-23.
BACKGROUND: We examined whether puromycin aminonucleoside (PAN)-induced nephrotic syndrome (NS) is associated with altered renal handling of water and sodium along with changes of renal abundance of aquaporins (AQP1 and...
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The Effect of alpha MSH Analogues on Rat Bones

Lim SK, Li SZ, Rhee Y, Chung SS, Jin YJ, Yook JI

Melanocortin is the downstream mediator of leptin signaling and absence of leptin signaling in ob/ob and db/db mice revealed the enhancement of bone formation through the central regulation. While alpha-melanocyte-stimulating...
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-Melanocyte Stimulating Hormone (MSH) decreases cyclosporine A induced apoptosis in cultured human proximal tubular cells

Jo SK, Lee SY, Han SY, Cha DR, Cho WY, Kim HK, Won NH

The pathogenesis of chronic cyclosporine A (CsA) nephrotoxicity has not been elucidated, but apoptosis is thought to play an important role in CsA induced tubular atrophy. Recently Fas-Fas ligand system...
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Effect of weight loss on cerebrospinal Fluid and Plasma Concentrations of NPY, alpha -MSH and leptin in Obese Women

Nam SY, Kim KW, Lee JH, Lee SJ, Kim KR, Song YD, Lim SK, Lee HC, Huh KB

  • KMID: 2199799
  • J Korean Soc Endocrinol.
  • 2001 Apr;16(2):199-209.
BACKGROUND: Although leptin and its principal mediators, neuropeptide Y (NPY) and -melanocyte stimulating hormone (MSH) are postulated to play a pivotal role in the energy balance in experimental animals,...
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Effects of alpha-melanocyte stimulating hormone on the expression of intercellular adhesion molecule-1 and renal function in acute ischemic renal failure in rats

Jo SK, Yoon JW, Cha DR, Cho WY, Kim HK, Won NH, Yoon SY, Chang KH

  • KMID: 2306159
  • Korean J Med.
  • 2000 Dec;59(6):641-650.
BACKGROUND: Acute renal failure is a reversible process in majority of cases but mechanisms of renal injury or recovery are poorly understood. Recently neutrophil infiltration is reported to potentiate inflammatory...
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Effects of alpha-Melanocyte Stimulating Hormone on Apoptosis and Fas Expression in Ischemic Renal Injury in Rats

Jo SK, Yoon JW, Cha DR, Cho WY, Kim HK, Won NH, Yoon SY, Chang KH, Kim KW

  • KMID: 2254515
  • Korean J Nephrol.
  • 2000 Sep;19(5):784-794.
Apoptosis frequently occurs in acute renal injury but molecular mechanisms responsible for this distinct form of cell death are largely unknown. Fas belongs to the TNF/nerve growth factor superfamily and...
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Structure and Function Analysis of alpha-MSH Analogues

Lim SK, Lee SC, Lee WT, Lee JH, Nam SY, Kim KR, Lee HC, Huh KB

  • KMID: 2331132
  • J Korean Soc Endocrinol.
  • 1999 Mar;14(1):18-26.
No abstract available.
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