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Relaxant Effect of Spermidine on Acethylcholine and High K+-induced Gastric Contractions of Guinea-Pig

Kim YC, Sim JH, Choi W, Kim CH, You RY, Xu WX, Lee SJ

In our previous study, we found that spermine and putrescine inhibited spontaneous and acetylcholine (ACh)-induced contractions of guinea-pig stomach via inhibition of L-type voltage- dependent calcium current (VDCCL). In this...
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Relaxation Patterns of Human Gastric Corporal Smooth Muscle by Cyclic Nucleotides Producing Agents

Kim YC, Choi W, Sung R, Kim H, You RY, Park SM, Youn SJ, Kim MJ, Song YJ, Xu WX, Lee SJ, Yun HY

To elucidate the mechanism of cyclic nucleotides, such as adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5' -cyclic monophosphate (cGMP), in the regulation of human gastric motility, we examined the effects...
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Regional Distribution of Interstitial Cells of Cajal, (ICC) in Human Stomach

Yun HY, Sung R, Kim YC, Choi W, Kim HS, Kim H, Lee GJ, You RY, Park SM, Yun SJ, Kim MJ, Kim WS, Song YJ, Xu WX, Lee SJ

We elucidated the distribution of interstitial cells of Cajal (ICC) in human stomach, using cryosection and c-Kit immunohistochemistry to identify c-Kit positive ICC. Before c-Kit staining, we routinely used hematoxylin...
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Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse

Hong SH, Sung R, Kim YC, Suzuki H, Choi W, Park YJ, Ji IW, Kim CH, Myung SC, Lee MY, Kang TM, You RY, Lee KJ, Lim SW, Yun HY, Song YJ, Xu WX, Kim HS, Lee SJ

Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K+ channels. Because contractility of uterine...
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Myometrial relaxation of mice via expression of two pore domain acid sensitive K⁺ (TASK-2) channels

Kyeong KS, Hong SH, Kim YC, Cho W, Myung SC, Lee MY, You RY, Kim CH, Kwon SY, Suzuki H, Park YJ, Jeong EH, Kim HS, Kim H, Lim SW, Xu WX, Lee SJ, Ji IW

Myometrial relaxation of mouse via expression of two-pore domain acid sensitive (TASK) channels was studied. In our previous report, we suggested that two-pore domain acid-sensing K⁺ channels (TASK-2) might be...
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