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Pharmacokinetics and bioequivalence of fixed-dose combination of candesartan cilexetil/amlodipine besylate (16/10 mg) versus coadministration of individual formulations in healthy subjects

Lee HW, Kang WY, Jung W, Gwon MR, Yang DH, Kim EH, Cho K, Yoon YR, Seong SJ

This study compared the pharmacokinetics of a fixed-dose combination (FDC) of candesartan (16 mg) and amlodipine (10 mg) versus coadministration of individual formulations to clarify the bioequivalence of the FDC....
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Understanding the pharmacokinetics of reversible metabolism

Cho S, Yoon YR

This tutorial introduces the mathematical skills required to obtain exact and approximate solutions for reversible reactions and provides graphical insights to help understand the pharmacokinetics of reversible metabolism. The matrix...
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Metabolic Profiling of Plasma from Pancreatic Cancer Patients in Korea

Gwon MR, Yoon YR, Seol YM, Choi YJ, Kim DU, Choe S, Lee SH, Hwang SY, Kim H

BACKGROUND/AIMS: Pancreatic cancer (PC) patients have poor prognoses because this cancer is typically diagnosed at an advanced stage and the therapeutic options are limited. We examined the potential of metabolic...
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Understanding the pharmacokinetics of prodrug and metabolite

Cho S, Yoon YR

This tutorial explains the pharmacokinetics of a prodrug and its active metabolite (or parent drug) using a two-step, consecutive, first-order irreversible reaction as a basic model for prodrug metabolism. In...
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Determination of sumatriptan in human plasma using liquid chromatography-mass spectrometry for pharmacokinetic study in healthy Korean volunteers

Cho S, Jegal M, Ohk B, Kim BK, Gwon MR, Kang WY, Seong SJ, Kim HJ, Lee HW, Yoon YR

This study describes the development of an analytical method to determine sumatriptan levels in human plasma using high performance liquid chromatography (HPLC) coupled with triple quadrupole tandem mass spectrometry (MS/MS)...
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Metabolomic analysis of healthy human urine following administration of glimepiride using a liquid chromatography-tandem mass spectrometry

Do EY, Gwon MR, Kim BK, Ohk B, Lee HW, Kang WY, Seong SJ, Kim HJ, Yoon YR

Glimepiride, a third generation sulfonylurea, is an antihyperglycemic agent widely used to treat type 2 diabetes mellitus. In this study, an untargeted urinary metabolomic analysis was performed to identify endogenous...
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Decreased potency of fimasartan in liver cirrhosis was quantified using mixed-effects analysis

Kim CO, Jeon S, Han S, Hong T, Park MS, Yoon YR, Yim DS

Fimasartan is a nonpeptide angiotensin II receptor blocker. In a previous study that compared the pharmacokinetics (PK) of fimasartan between patients with hepatic impairment (cirrhosis) and healthy subjects, the exposure...
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Benign Thyroid and Neck Lesions Mimicking Malignancy with False Positive Findings on Positron Emission Tomography-Computed Tomography

Yoon YR, Kim SY, Lee SM, Lee DY

The increasing use of positron emission tomography-computed tomography (PET/CT) has led to the frequent detection of incidental thyroid and neck lesions with increased ¹⁸F-deoxyglucose (FDG) uptake. Although lesions with increased...
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Development and validation of analytical method for the determination of radotinib in human plasma using liquid chromatography-tandem mass spectrometry

Seo HB, Cho S, Yoon YR, Yim DS

This study describes the development of an analytical method to determine radotinib levels in human plasma using high performance liquid chromatography (HPLC) coupled with triple quadrupole tandem mass spectrometry (MS/MS)...
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Effects of 12-week Vegetarian Diet on the Nutritional Status, Stress Status and Bowel Habits in Middle School Students and Teachers

Lee BR, Ko YM, Cho MH, Yoon YR, Kye SH, Park YK

This study investigated the effect of switching normal diet to vegetarian diet rich in vegetables and fruits for school foodservice and home meal on the nutritional status, bowel habit improvement...
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Development and validation of a UPLC-MS/MS method for the quantification of acetaminophen in human plasma and its application to pharmacokinetic studies

Cha J, Kim BK, Gwon MR, Lee J, Ohk B, Kang WY, Lim MS, Seong SJ, Kim HJ, Lee HW, Yoon YR

We developed an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of acetaminophen concentration in human plasma. Following protein precipitated extraction, the analytes were separated and analyzed using...
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Deficiency of Lipocalin-2 Promotes Proliferation and Differentiation of Osteoclast Precursors via Regulation of c-Fms Expression and Nuclear Factor-kappa B Activation

Kim HJ, Ohk B, Kang WY, Seong SJ, Suk K, Lim MS, Kim SY, Yoon YR

BACKGROUND: Lipocalin-2 (LCN2), a small glycoprotein, has a pivotal role in diverse biological processes such as cellular proliferation and differentiation. We previously reported that LCN2 is implicated in osteoclast formation...
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A Case of En Plaque Meningioma of Jugular Foramen with Image Findings of Differential Diagnosis

Yoon YR, Han JK, Lee CK

Primary meningioma of jugular foramen is extremely rare, while paraganglioma or nerve sheath tumor are relatively common in jugular foramen. We reported a case of primary meningioma of jugular foramen....
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Retroperitoneal Bronchogenic Cyst Presenting Paraadrenal Tumor Incidentally Detected by 18F-FDG PET/CT

Yoon YR, Choi J, Lee SM, Kim YJ, Cho HD, Lee JW, Jeon YS

A follow-up 18F-fluorodeoxyglucose (18F-FDG) PET/CT scan of a 57-year-old asymptomatic male who had undergone total thyroidectomy for thyroid cancer revealed a 5.0 x 4.0-cm, well-defined, ovoid-shaped mass around the left...
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Population pharmacokinetic analysis of the multiple peaks phenomenon in sumatriptan

Lee J, Lim MS, Seong SJ, Park SM, Gwon MR, Han S, Lee SM, Kim W, Yoon YR, Yoo HD

The objective of this study was to develop a population pharmacokinetic (PK) model for sumatriptan, which frequently shows an atypical absorption profile with multiple peaks. Sumatriptan, a selective agonist for...
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Serious adverse events during clinical trial for pharmacokinetic interaction between telmisartan and chlorthalidone in healthy Korean subjects: A case report

Seong SJ, Yoon YR, Lim MS

Telmisartan is an angiotensin II receptor antagonist and chlorthalidone is a thiazide-like diuretics. In this study, we report serious adverse events (SAEs) during clinical trial for pharmacokinetic interaction between telmisartan...
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Melanocortin 4 Receptor and Dopamine D2 Receptor Expression in Brain Areas Involved in Food Intake

Yoon YR, Baik JH

BACKGROUND: The melanocortin 4 receptor (MC4R) is involved in the regulation of homeostatic energy balance by the hypothalamus. Recent reports showed that MC4R can also control the motivation for food...
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Pharmacometabolomics: Current Applications and Future Perspectives

Kim HJ, Yoon YR

  • KMID: 2317851
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):8-10.
Metabolomics, a novel "omics" platform, is a powerful tool for the discovery of clinically useful biomarkers and biochemical processes to improve diagnosis and therapy. Through the use of advanced analytical...
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Effects of Age and Sex on the Pharmacokinetics of Tacrolimus during Pediatric Kidney Transplantation: A Single Center Study

Choe JY, Jang KM, Hwang YJ, Choi BS, Park JK, Yoon YR, Kim CD, Cho MH

  • KMID: 2196562
  • J Korean Soc Pediatr Nephrol.
  • 2014 Apr;18(1):18-23.
PURPOSE: The pharmacokinetics of tacrolimus, one of the most widely used immunosuppressive drugs, are known to vary by sex, age, and ethnicity during pediatric transplantation. This study assessed the pharmacokinetic...
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A Study on Current Status of Clinical Trial Pharmacy in Domestic Clinical Trial Institution

Jang YJ, Kang W, Lee J, Lee HW, Park MS, Yoon YR

  • KMID: 2334547
  • J Korean Soc Clin Pharmacol Ther.
  • 2013 Jun;21(1):71-81.
BACKGROUND: There is a lack of research on the status of clinical trial pharmacy and clinical trial pharmacist (CTP) in Korea. This study was aimed to investigate the current status...
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