- A Case of Fixed Drug Eruption Induced by Tegafur-Uracil(TEGASIL)
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Heo YS, Song HJ, Oh CH
- KMID: 2247720
- Korean J Dermatol.
- 2010 Feb;48(2):155-157.
A mixture of tegafur and uracil (TEGASIL) is a common antineoplastic agent. Tegafur is a fluoropyrimidine structurally similar to 5-fluorouracil (5-FU); uracil slows the degradation of 5-FU by dihydropyrimidine dehydrogenase,... -
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- Effects of pyrimidine salvage inhibitors on uracil incorporation of Toxoplasma gondii
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Youn JH, Nam HW, Kim DJ, Choi WY
- KMID: 1043393
- Korean J Parasitol.
- 1990 Jun;28(2):79-84.
- doi: 10.3347/kjp.1990.28.2.79
Metabolic inhibitors which act in the process of pyrimidine salvage influenced on the uracil incorporation into nucleic acids of Toxoplasma. Inhibitors of dihydrofolate reductase, pyrimethamine and methotrexate, and inhibitors of... -
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- Discoid Lupus Erythematosus-like Eruption Induced by Tegafur - Uracil (UFT)
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Yoon J, Seo SH, Kye YC, Ahn HH
- KMID: 2301813
- Korean J Dermatol.
- 2010 Nov;48(11):1004-1007.
The second-generation oral anticancer agent UFT is a combination of uracil, which has fluorouracil's (5-FU) degradation-inhibitory effect, and tegafur, which is slowly converted to 5-FU in vivo, and UFT shows... -
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- A Case of 5-fluorouracil-induced Phototoxicity
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Cho EA, Kim SY
- KMID: 2087201
- Korean J Dermatol.
- 2006 Nov;44(11):1364-1366.
5-fluorouracil (5-FU) is an antimetabolite which prevents thymine synthesis and suppresses the utilization of preformed uracil. A variety of cutaneous reactions have been reported with the use of systemic 5-FU,... -
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- Asymmetrical distribution of P2Y nucleotide receptors in rabbit inner medullary collecting duct cells
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Woo JS, Jung JS, Kim YK
- KMID: 1917024
- Korean J Physiol Pharmacol.
- 2000 Aug;4(4):311-318.
We cultured the rabbit inner medullary collecting duct (IMCD) cells as monolayers on collagen-coated membrane filters, and investigated distribution of the P2Y receptors by analyzing nucleotide-induced short circuit current (Isc) responses. Exposure to... -
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- The Efficient Transformation of Pleurotus ostreatus using REMI Method
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Joh JH, Kim BG, Chu KS, Kong WS, Yoo YB, Lee CS
- KMID: 2052977
- Mycobiology.
- 2003 Mar;31(1):32-35.
- doi: 10.4489/MYCO.2003.31.1.032
Restriction enzyme-mediated integration (REMI) was used to transform uracil auxotrophs of Pleurotus ostreatus to prototrophy. When protoplasts of Pleurotus ostreatus were treated by the reaction mixture containing 10 units of... -
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- Uracil-DNA glycosylase-treated reverse transcription loop-mediated isothermal amplification for rapid detection of avian influenza virus preventing carry-over contamination
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Kim EM, Jeon HS, Kim JJ, Shin YK, Lee YJ, Yeo SG, Park CK
- KMID: 2413144
- J Vet Sci.
- 2016 Sep;17(3):421-425.
- doi: 10.4142/jvs.2016.17.3.421
Here, we describe a uracil-DNA glycosylase (UNG)-treated reverse transcription loop-mediated isothermal amplification (uRT-LAMP) for the visual detection of all subtypes of avian influenza A virus (AIV). The uRT-LAMP assay can... -
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- Site-Specific Mutagenesis in Escherichia coli by Bulky Exocyclic Amino-Substituted Guanine and Adenine Derivatives in Double-Stranded or Gapped Plasmids
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Moon KY
- KMID: 1807225
- Cancer Res Treat.
- 2003 Feb;35(1):75-80.
PURPOSE: 7-Bromomethylbenz[alpha]anthracene is a known mutagen and carcinogen. The mutagenic potency of its two major DNA adducts, i.e., N2-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyguanosine (b[alpha]a2G) and N6-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyadenosine (b[alpha]a6A), as well as the simpler benzylated analogs,... -
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- Chemical Constituents of the Fruiting Bodies of Clitocybe nebularis and Their Antifungal Activity
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Kim YS, Lee IK, Seok SJ, Yun BS
- KMID: 2411406
- Mycobiology.
- 2008 Jun;36(2):110-113.
During a continuing search for antimicrobial substances from Korean native wild mushroom extracts, we found that the methanolic extract of the fruiting body of Clitocybe nebularis exhibited mild antifungal activity... -
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- Oral Tegafur-uracil Plus Folinic Acid versus Intravenous 5-fluorouracil Plus Folinic Acid as Adjuvant Chemotherapy of Colon Cancer
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Kim DJ, Kim TI, Suh JH, Cho YS, Shin SK, Kang JK, Kim NK, Kim WH
- KMID: 720907
- Yonsei Med J.
- 2003 Aug;44(4):665-675.
- doi: 10.3349/ymj.2003.44.4.665
To compare, in terms of compliance, toxicity, quality of life (QOL) and efficacy, intravenous 5-fluorouracil plus folinic acid with oral tegafur-uracil plus folinic acid as postoperative adjuvant chemotherapy after curative... -
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- Lesch-Nyhan syndrome and purine and pyrimidine metabolism didorders
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Kim SZ
- KMID: 2168076
- Hanyang Med Rev.
- 2005 Aug;25(3):92-101.
Purine & pyrimidine nucleotides are basic constituents of cellular DNA and RNA polynucleotides. Their function includes regulation of cell metabolism and function, energy conservation and transport and formation of coenzymes... -
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- Comparison of DPP-4 Inhibitors
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Kim NH, Kim SG
- KMID: 2173918
- J Korean Diabetes.
- 2013 Sep;14(3):111-119.
- doi: 10.4093/jkd.2013.14.3.111
During past several years, a novel class of antihyperglycemic agents, dipeptidyl peptidase-4 (DPP-4) inhibitors, has become one of the most important options in the management of type 2 diabetes. These... -
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- The Protective Effect of Mannitol and Methylprednisolone in the Acute Focal Cerebral Ischemia in Cats
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Shin KM
- KMID: 2170822
- Ewha Med J.
- 1988 Dec;11(4):283-297.
- doi: 10.12771/emj.1988.11.4.283
It is the purpose of the this experimental study to investigate the protective effect of pretreatment of mannitol and methylprednisolone(MP) on the changes of the high-energy metabolites(nucleotides ; derivatives of... -
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- DNA methylation of Bcl-2 family genes in cancer cells
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Kang Y, Lee SY, Jung SG, Han J, Ko JJ, Bae J, Na YJ, Lee C, Mock JU, Kim SJ, Hwang YY
- KMID: 2273147
- Korean J Obstet Gynecol.
- 2007 Jul;50(7):997-1002.
OBJECTIVE: Promoter methylation of Bcl-2 family genes in cancer cells were studied to verify possible correlation between DNA methylation pattern of Bcl-2 family members and cancer. METHODS: The genomic DNAs... -
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- Clinical Pharmacokinetics of Tegafur Administered with Epirubicin and Cisplatin in Patients with Advanced Gastric Cancer
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Kang JH, Kim YL, Cho HK, Lee ES, Cha SJ, Hong YS, Lee KS, Kuh HJ
- KMID: 2166181
- Cancer Res Treat.
- 2003 Jun;35(3):224-231.
PURPOSE: Tegafur, an oral prodrug of 5-fluorouracil (5-FU), has been used in the treatment of gastric cancers. UFT (tegafur + uracil) has been developed to enhance the efficacy of tegafur.... -
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- Effects of Uridine 5'-Triphosphate on the Vascular Tone of Rat Thoracic Aorta
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Park KS, Kong ID, Lee JW
- KMID: 2228958
- Korean Circ J.
- 1995 Feb;25(1):68-77.
- doi: 10.4070/kcj.1995.25.1.68
BACKGROUND: Uracil nucleotides are stored in platelets and all other cells, and are released into the extracellular space upon stimulation. They show various biological responses but their actions and mechanism... -
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- High-dose oral tegafur-uracil maintenance therapy in patients with uterine cervical cancer
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Sakaguchi , Motohara T, Saito F, Takaishi K, Fukumatsu , Tohya T, Shibata S, Mimori H, Tashiro H, Katabuchi
- KMID: 2160805
- J Gynecol Oncol.
- 2015 Jul;26(3):193-200.
- doi: 10.3802/jgo.2015.26.3.193
OBJECTIVE: The aim of this study was to determine the efficacy and toxicity of oral administration of tegafur-uracil (UFT) at a high dose, 600 mg/day, based on the tegafur dose,... -
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- Development of inhibitors of pyrimidine metabolism
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Cha S
- KMID: 1105559
- Yonsei Med J.
- 1989 Dec;30(4):315-326.
- doi: 10.3349/ymj.1989.30.4.315
Benzylacyclouridines were developed as specific and potent competitive inhibitors of uridine phosphorylase with Ki values in the nanomolar range. These compounds have no activity against thymidine phosphorylase, uridine kinase,... -
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- Volume-reserving Surgery after Photodynamic Therapy for Biliary Papillomatosis: A Case Report
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Cheong CO, Lim JH, Park JS, Park SW, Kim HK, Kim KS
- KMID: 2373313
- Korean J Gastroenterol.
- 2015 Jul;66(1):55-58.
- doi: 10.4166/kjg.2015.66.1.55
Biliary papillomatosis is rare, and its pathogenic mechanisms are not yet clear. Because of its high risk for malignancy transformation, surgical resection is regarded as a standard treatment. Photodynamic therapy... -
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- Cloning and Sequence Analysis of the Full-length cDNA of Coxsackievirus B3 Isolated in Korea
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Chung YS, Kim KS, Park JK, Lee YS, Shin SY, Cheon DS, Jee Y, Kim MB, Na BK, Yoon JD, Lee KH, Song CY
- KMID: 1896564
- J Korean Soc Virol.
- 2000 Mar;30(1):71-81.
We have determined and analyzed the full-length cDNA sequence of a coxsackievirus B3 (CVB3) Korean isolate (CVB3-Korea/97) which has been known as a general human pathogen. The whole genome contains... -
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