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Pyrrolidine Dithiocarbamate Inhibits Nuclear Factor kappaB and Toll-Like Receptor 4 Expression in Rats with Acute Necrotizing Pancreatitis

Xu M, Wang KN, Wu K, Wang XP

BACKGROUND/AIMS: To investigate the expression of Toll-like receptor 4 (TLR4) in the pancreases of rats with acute necrotizing pancreatitis (ANP) and any changes upon treatment with pyrrolidine dithiocarbamate (PDTC), an...
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Peroxisome Proliferator-Activated Receptor-Gamma Expression in the Lung Tissue of Obese Rats

Hwang SJ, Kim JH, Shim JW, Kim DS, Jung HL, Park MS, Lee WY, Kim SY, Shim JY

PURPOSE: Obesity is a risk factor for asthma and type II diabetes. Peroxisome proliferator-activated receptor (PPAR)-gamma has been suggested to regulate inflammatory responses in diabetes and asthma. We investigated whether...
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Eradication of Helicobacter pylori Increases Ghrelin mRNA Expression in the Gastric Mucosa

Lee ES, Yoon YS, Park CY, Kim HS, Um TH, Baik HW, Jang EJ, Lee S, Park HS, Oh SW

It has been suggested that Helicobacter pylori eradication may influence production of some peptides in the stomach, which can affect appetite. This hypothesis is controversial. To verify the hypothesis, we...
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Anti-inflammatory Mechanism of Lactobacillus rhamnosus GG in Lipopolysaccharide-stimulated HT-29 Cell

Lee SK, Yang KM, Cheon JH, Kim TI, Kim WH

BACKGROUND/AIMS: Probiotics are live non-pathogenic organisms that belong to the resident microflora, and confer health benefits by multiple mechanisms. Lactobacillus rhamnosus GG (LGG) is one of the probiotic bacteria that...
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Hepatic Ischemic Preconditioning Provides Protection Against Distant Renal Ischemia and Reperfusion Injury in Mice

Lee JA, Choi JW, In JH, Jung HS, Kim YS, Jeon YS, Kang YJ, Kim DW, Lim YG, Park JH, Joo JD

We previously demonstrated that there are acute and delayed phases of renal protection against renal ischemia and reperfusion (IR) injury with renal ischemic preconditioning (IPC). This study assessed whether hepatic...
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Cytokine response in Balb/c mice infected with Francisella tularensis LVS and the Pohang isolate

Kim EJ, Park SH, Choi YS, Shim SK, Park MY, Park MS, Hwang KJ

We investigated the immune response induced by the Francisella (F.) tularensis live vaccine strain (LVS) and the Pohang isolate. After the Balb/c mice were infected intradermally (i.d) with 2 x...
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Acute Effects of Intravenous Administration of Pamidronate in Patients with Osteoporosis

Lim MJ, Kwon SR, Park SG, Park W

We investigated acute effects of intermittent large dose bisphophonate therapy in osteoporotic patients. Peripheral blood mononuclear cells were incubated with alendronate (100 micrometer) for 18 hr, in vitro and cytokine...
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Colchicine-derived compound CT20126 promotes skin allograft survival by regulating the balance of Th1 and Th2 cytokine production

Lee SJ, Namkoong S, Ha KS, Nam WD, Kwon YG, Lee H, Yoon EY, Chang DJ, Kim SO, Kim YM

  • KMID: 1094664
  • Exp Mol Med.
  • 2007 Apr;39(2):230-238.
Colchicine has been shown to regulate the expression of inflammatory gene, but this compound possesses much weaker anti-inflammatory activity. In this study, we synthesized a new colchicine derivative CT20126 and...
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