- Principles of transparency and clinical trial registration
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Yim DS
- KMID: 2390928
- Transl Clin Pharmacol.
- 2017 Sep;25(3):113-113.
- doi: 10.12793/tcp.2017.25.3.113
No abstract available. -
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- Intracerebroventricular drug administration
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Atkinson A
- KMID: 2390930
- Transl Clin Pharmacol.
- 2017 Sep;25(3):117-124.
- doi: 10.12793/tcp.2017.25.3.117
Among the various routes of drug administration, perhaps the least studied is intracerebroventricular (ICV) administration. This route has been shown to be particularly useful in administering to the central nervous... -
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- Pharmacometric models simulation using NONMEM, Berkeley Madonna and R
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Park WS
- KMID: 2390931
- Transl Clin Pharmacol.
- 2017 Sep;25(3):125-133.
- doi: 10.12793/tcp.2017.25.3.125
In this tutorial, we introduce a differential equation simulation model for use in pharmacometrics involving NONMEM, Berkeley Madonna, and R. We report components of the simulation code and similarities/differences between... -
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- Prediction and visualization of CYP2D6 genotype-based phenotype using clustering algorithms
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Kim EY, Shin SG, Shin JG
- KMID: 2390935
- Transl Clin Pharmacol.
- 2017 Sep;25(3):147-152.
- doi: 10.12793/tcp.2017.25.3.147
This study focused on the role of cytochrome P450 2D6 (CYP2D6) genotypes to predict phenotypes in the metabolism of dextromethorphan. CYP2D6 genotypes and metabolic ratios (MRs) of dextromethorphan were determined... -
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- Inhibition of indoxyl sulfate-induced intrarenal renin-angiotensin system activation: targeting the aryl hydrocarbon receptor
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Akbar MF
- KMID: 2390929
- Transl Clin Pharmacol.
- 2017 Sep;25(3):114-116.
- doi: 10.12793/tcp.2017.25.3.114
Indoxyl sulfate, a protein-bound uremic toxin, leads to CKD (chronic kidney disease) progression and its complications through the activation of AhR (aryl hydrocarbon receptor) and RAS (renin-angiotensin system). Inhibition of... -
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- Caffsim: simulation of plasma caffeine concentrations implemented as an R package and Web-applications
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Han S, Cho YS, Yoon SK, Kim H, Bae KS
- KMID: 2390934
- Transl Clin Pharmacol.
- 2017 Sep;25(3):141-146.
- doi: 10.12793/tcp.2017.25.3.141
Caffeine is a naturally-occurring central nervous system stimulant found in plant constituents including coffee, cocoa beans, and tea leaves. Consumption of caffeine through imbibing caffeinated drinks is rapidly growing among... -
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- Hemorrhagic pericarditis associated with rivaroxaban in an atrial fibrillation patient with pacemaker
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Rhew SH, Kim SS
- KMID: 2390933
- Transl Clin Pharmacol.
- 2017 Sep;25(3):138-140.
- doi: 10.12793/tcp.2017.25.3.138
Rivaroxaban is a new oral anticoagulant used for the prevention of stroke in patients with atrial fibrillation. Hemorrhagic pericarditis is known to occur with rivaroxaban; however, only a few case... -
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- A case of Waldenström's macroglobulinemia treated using clarithromycin and prednisolone
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Ohe M, Hashino S, Shida H, Horita T, Sugiura M
- KMID: 2390932
- Transl Clin Pharmacol.
- 2017 Sep;25(3):134-137.
- doi: 10.12793/tcp.2017.25.3.134
We report a case of Waldenström's macroglobulinemia (WM) treated using clarithromycin (CAM) and prednisolone (PSL). An 84-year-old woman was admitted to our hospital for bleeding after a tooth extraction and... -
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- Comparison of pharmacokinetic characteristics of sildenafil citrate chewable tablets and film-coated tablets in healthy male subjects
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Yoo H, Cho SM, Choi YW, Lee HJ, Kwon JH, Kim SW, Kim JW, Lee S, Hong JH
- KMID: 2390936
- Transl Clin Pharmacol.
- 2017 Sep;25(3):153-156.
- doi: 10.12793/tcp.2017.25.3.153
UI14SDF100CW is a chewable tablet of sildenafil citrate, which was developed to improve compliance through convenience of administration. The purpose of this study was to compare the pharmacokinetic (PK) properties... -
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