Transl Clin Pharmacol.  2017 Sep;25(3):125-133. 10.12793/tcp.2017.25.3.125.

Pharmacometric models simulation using NONMEM, Berkeley Madonna and R

Affiliations
  • 1Q-fitter Inc., 6th Floor, 412 Yeoksam-ro, Gangnam-gu, Seoul 06199, Korea. ws.park@qfitter.com

Abstract

In this tutorial, we introduce a differential equation simulation model for use in pharmacometrics involving NONMEM, Berkeley Madonna, and R. We report components of the simulation code and similarities/differences between software, rather than how to use each software. Depending on the purpose of the simulation, an appropriate tool can be selected for effective communication.

Keyword

NONMEM; Berkeley Madonna; R; Pharmacometrics; Simulation

MeSH Terms

Computer Simulation
Software

Figure

  • Figure 1 The structural model used in the example.


Reference

1. ICON plc. NONMEM®. Accessed 15 May 2017. https://www.iconplc.com/innovation/nonmem/.
2. University of California Berkeley. Berkeley Madonna. Accessed 15 May 2017. http://www.berkeleymadonna.com/.
3. The R Project for Statistical Computing. R. Accessed 15 May 2017. https://www.r-project.org/.
4. Krause A, Lowe PJ. Visualization and communication of pharmacometric models with berkeley madonna. CPT Pharmacometrics Syst Pharmacol. 2014; 3:e116. DOI: 10.1038/psp.2014.13. PMID: 24872204.
Article
5. Wojciechowski J, Hopkins AM, Upton RN. Interactive Pharmacometric Applications Using R and the Shiny Package. CPT Pharmacometrics Syst Pharmacol. 2015; 4:e00021. DOI: 10.1002/psp4.21. PMID: 26225240.
Article
6. Wang W, Hallow KM, James DA. A Tutorial on RxODE: Simulating Differential Equation Pharmacometric Models in R. CPT Pharmacometrics Syst Pharmacol. 2016; 5:3–10. DOI: 10.1002/psp4.12052. PMID: 26844010.
Article
7. RStudio, Inc. RStudio. Accessed 15 May 2017. https://www.rstudio.com/.
8. Hallow M, Fidler ML, Wang W. Package ‘RxODE’. Accessed 15 May 2017. https://cran.r-project.org/web/packages/RxODE/RxODE.pdf.
9. Lavielle M. Pharmacometrics: some Shiny applications. Accessed 15 May 2017. http://webpopix.org/shiny/ShinyExamples.html.
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