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Decreased potency of fimasartan in liver cirrhosis was quantified using mixed-effects analysis

Kim CO, Jeon S, Han S, Hong T, Park MS, Yoon YR, Yim DS

Fimasartan is a nonpeptide angiotensin II receptor blocker. In a previous study that compared the pharmacokinetics (PK) of fimasartan between patients with hepatic impairment (cirrhosis) and healthy subjects, the exposure...
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Development of an automated appendix generation system (ARGUS) for clinical study reports

Jang D, Han S, Yim DS

Data handling and tabulation are a time-consuming job when writing appendices for clinical study reports. The authors have developed an automated appendix generation system (ARGUS) conforming to the CDISC/SDTM standard...
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Hydrochlorothiazide does not increase furosemide's effects in end-stage renal disease

Huh W, Oh HY, Han JS, Jang IJ, Yim DS

Diuretic therapy for the treatment of edema in patients with end-stage renal disease (ESRD) is unsatisfactory, and a combination of thiazide and loop diuretics may produce better clinical effects. To...
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Validated UPLC-MS/MS method for the determination of tadalafil in human plasma and its application to a pharmacokinetic study

Kim KY, Nam M, Kwon HJ, Kim KH, Kang SH, Kim SI, Kim CW, Cho SH

A simple, rapid, and reliable UPLC-MS/MS method was developed and validated for the determination of tadalafil in human plasma. The plasma samples were deproteinized with acetonitrile. Chromatographic separation was performed...
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Enhancement of skin permeation of vitamin C using vibrating microneedles

Lee CA, Baek JS, Kwag DG, Lee HJ, Park J, Cho CW

This study was performed to evaluate the use of vibrating microneedles for the transdermal delivery of vitamin C. The microneedles were designed to vibrate at three levels of intensity. In...
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Comparative pharmacokinetic and tolerability evaluation of two simvastatin 20 mg formulations in healthy Korean male volunteers

Moon SJ, Lee S, Jang K, Yu KS, Yim SV, Kim BH

Simvastatin is used to reduce plasma cholesterol by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and is primarily used to treat hypercholesterolemia. This study was conducted to assess the bioequivalence between...
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Forensic science meets clinical pharmacology: pharmacokinetic model based estimation of alcohol concentration of a defendant as requested by a local prosecutor's office

Lim HS, Soung JH, Bae KS

Drunk driving is a serious social problem. We estimated the blood alcohol concentration of a defendant on the request of local prosecutor's office in Korea. Based on the defendant's history,...
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Tutorial for beginners: the concept of clearance explained using the example of a vacuum cleaner

Yim DS

Clearance is a key concept in pharmacokinetics, but it is not easy to understand for beginners. This tutorial aims to help beginners by using the analogy of a vacuum cleaner...
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