- Is Activating Transcription Factor 3 Up-Regulated in Patients with Hypospadias?
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Gurbuz C, Demir S, Zemheri E, Canat L, Kilic M, Caskurlu T
- KMID: 1997025
- Korean J Urol.
- 2010 Aug;51(8):561-564.
- doi: 10.4111/kju.2010.51.8.561
PURPOSE: Even though hypospadias is one of the most common congenital anomalies, the cause of hypospadias is largely unknown. With regard to molecular biology and microarray technology, it appears that... -
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- Kahweol from Coffee Induces Apoptosis by Upregulating Activating Transcription Factor 3 in Human Colorectal Cancer Cells
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Park GH, Song HM, Jeong JB
- KMID: 2378813
- Biomol Ther.
- 2017 May;25(3):337-343.
- doi: 10.4062/biomolther.2016.114
Kahweol as a coffee-specific diterpene has been reported to induce apoptosis in human cancer cells. Although some molecular targets for kahweol-mediated apoptosis have been elucidated, the further mechanism for apoptotic... -
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- Naringenin-Mediated ATF3 Expression Contributes to Apoptosis in Human Colon Cancer
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Song HM, Park GH, Eo HJ, Jeong JB
- KMID: 2170525
- Biomol Ther.
- 2016 Mar;24(2):140-146.
- doi: 10.4062/biomolther.2015.109
Naringenin (NAR) as one of the flavonoids observed in grapefruit has been reported to exhibit an anti-cancer activity. Activating transcription factor 3 (ATF3) is associated with apoptosis in human colon... -
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- Transcription Factors Regulating Inflammatory Cytokine Production Are Differentially Expressed in Peripheral Blood Mononuclear Cells of Behçet Disease Depending on Disease Activity
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Woo MY, Yun SJ, Lee MJ, Kim K, Lee ES, Park S
- KMID: 2394840
- Ann Dermatol.
- 2017 Apr;29(2):173-179.
- doi: 10.5021/ad.2017.29.2.173
BACKGROUND: Behçet disease (BD) is a relapsing inflammatory disease with increased production of inflammatory cytokines in peripheral blood mononuclear cells (PBMCs); however, the underlying molecular mechanisms are not well known. OBJECTIVE:... -
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- Expression of Activating Transcription Factor 3 in Ischemic Penumbra Region Following Focal Cerebral Ischemia
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Song DY, OH KM, Lee JH, Woo RS, Lee YJ, Han JT, Baik TK
- KMID: 2092940
- Korean J Anat.
- 2008 Sep;41(3):173-183.
It has been demonstrated that some of immediate early genes (IEGs) such as c-Jun or fos are induced immediately following neuronal injury and they play an important role in determining... -
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- ATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells
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Kim KJ, Lee J, Park Y, Lee SH
- KMID: 2380346
- Biomol Ther.
- 2015 Mar;23(2):134-140.
- doi: 10.4062/biomolther.2014.107
Conjugated linoleic acids (CLA) are a family of isomers of linoleic acid. CLA increases growth arrest and apoptosis of human colorectal cancer cells through an isomer-specific manner. ATF3 belongs to... -
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- Activating transcription factor-3 induction is involved in the anti-inflammatory action of berberine in RAW264.7 murine macrophages
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Bae YA, Cheon HG
- KMID: 2371059
- Korean J Physiol Pharmacol.
- 2016 Jul;20(4):415-424.
- doi: 10.4196/kjpp.2016.20.4.415
Berberine is an isoquinoline alkaloid found in Rhizoma coptidis, and elicits anti-inflammatory effects through diverse mechanisms. Based on previous reports that activating transcription factor-3 (ATF-3) acts as a negative regulator... -
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- Can We Use Single Nucleotide Polymorphism and Runt Domain Transcription Factor 3 Methylation as Tumor Markers for Bladder Cancer?
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Kim WJ, Kim YJ
- KMID: 2311855
- Korean J Urol.
- 2009 Apr;50(4):311-319.
PURPOSE: Although many tumor markers have been evaluated in relation to bladder cancer, none of these biomarkers reported to date has shown sufficient sensitivity and specificity for the detection of... -
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- The Relationship between RUNX3 Inactivation and Its Pathological Features in Renal Cell Carcinoma
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Kwon WA, Park C, Kim EJ, Ha YS, Kim YJ, Yun SJ, Lee SC, Kim WJ
- KMID: 2311839
- Korean J Urol.
- 2009 May;50(5):432-438.
PURPOSE: DNA methylation is a key regulator of gene transcription and genomic stability, and alterations in DNA methylation are frequently detected in human tumors. Recent study has suggested that inactivation... -
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- DNA Methylation of RUNX3 in Papillary Thyroid Cancer
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Ko HJ, Kim BY, Jung CH, Chun SW, Mok JO, Kim YJ, Park HK, Kim CH, Kim SJ, Byun DW, Suh KI, Yoo MH, Kang SG
- KMID: 2432932
- Korean J Intern Med.
- 2012 Dec;27(4):407-410.
BACKGROUND/AIMS: The relationship between Runt-related transcription factor 3 (RUNX3) gene inactivation and various solid tumors has been reported; however, little information is available about RUNX3 in thyroid cancers. METHODS: We evaluated... -
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- Co-localization of activating transcription factor 3 and phosphorylated c-Jun in axotomized facial motoneurons
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Park BG, Lee JS, Lee JY, Song DY, Jeong SW, Cho BP
- KMID: 1447435
- Anat Cell Biol.
- 2011 Sep;44(3):226-237.
- doi: 10.5115/acb.2011.44.3.226
Activating transcription factor 3 (ATF3) and c-Jun play key roles in either cell death or cell survival, depending on the cellular background. To evaluate the functional significance of ATF3/c-Jun in... -
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- The Role of ATF3 Expression and Calcineurin Inhibition in the Putative Cancer Stem Cell Fraction of Human Cutaneous Squamous Cell Carcinoma
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Chung BY, Kim BW, Lee MW, Choi JH, Kim CD, Chang SE
- KMID: 2246267
- Korean J Dermatol.
- 2014 Oct;52(10):692-700.
BACKGROUND: A previous study reported that calcineurin inhibition by cyclosporin A (CsA) showed tumor-enhancing effects through the induction of the ATF3 transcription factor and the associated suppression of p53. The... -
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- Epigenetic inactivation of RUNX3 in colorectal cancer
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Shin EJ, Kim HJ, Son MW, Ahn TS, Lee HY, Lim DR, Bae SB, Jeon S, Kim H, Jeong D, Lee MS, Kim DS, Noh JS, Baek MJ
- KMID: 2405335
- Ann Surg Treat Res.
- 2018 Jan;94(1):19-25.
- doi: 10.4174/astr.2018.94.1.19
PURPOSE: Emerging evidence indicates that runt-related transcription factor 3 (RUNX3) is an important tumor suppressor gene in several cancer types, including colorectal cancer (CRC). However, the clinical significance of RUNX3... -
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- Purification and Characterization of Novel Genes of Human Fetal Astrocytes
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Park JY, Seo HS, Choi SJ, Park HS, Lee KH, Koh CM, Lee SS
- KMID: 1615430
- J Bacteriol Virol.
- 2003 Mar;33(1):101-112.
Astrocytes are ubiquitous in the brain and have multiple functions. It is becoming clear that they play an important role in monitoring the neuromicroenvironment, information processing, and signaling in the... -
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- A Case of Alveolar Soft Part Sarcoma of the Pleura
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Ju HU, Seo KW, Jegal Y, Ahn JJ, Lee YJ, Kim YM, Oak C, Ra SW
- KMID: 1429216
- J Korean Med Sci.
- 2013 Feb;28(2):331-335.
- doi: 10.3346/jkms.2013.28.2.331
Alveolar soft part sarcoma (ASPS) is a rare malignant soft-tissue neoplasm of unknown histogenesis. The two main sites of occurrence are the lower extremities in adults and the head and... -
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- Prognostic Significance of Methylation Profiles in Urothelial Carcinomas of the Bladder
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Park HJ, Lee EJ, Ha SY, Kwon GY, Oh YL, Kim KM, Kim DS, Seo S, Lee HM, Choi HY
- KMID: 2277539
- Korean J Pathol.
- 2010 Dec;44(6):623-630.
BACKGROUND: Study on epigenetics of urothelial carcinomas has expanded and allowed better understanding of their correlation with clinicopathologic features. The aim of this study was to determine reliable predictive epigenetic... -
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- Sulfuretin Prevents Obesity and Metabolic Diseases in Diet Induced Obese Mice
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Kim S, Song NJ, Chang SH, Bahn G, Choi Y, Rhee DK, Yun UJ, Choi J, Lee J, Yoo JH, Shin D, Park KM, Kang H, Lee S, Ku JM, Cho YS, Park KW
- KMID: 2432074
- Biomol Ther.
- 2019 Jan;27(1):107-116.
- doi: 10.4062/biomolther.2018.090
The global obesity epidemic and associated metabolic diseases require alternative biological targets for new therapeutic strategies. In this study, we show that a phytochemical sulfuretin suppressed adipocyte differentiation of preadipocytes... -
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