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Protective role of curcumin against lipopolysaccharide-induced inflammation and apoptosis in human neutrophil

Cho KB, Park CH, Kim J, Tin TD, Kwak SH

Background: Sepsis, an uncontrolled host response to infection, may be life-threatening organ injury. Neutrophils play a critical role in regulation of host immune response to infection. Curcumin, known as a...
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Effect of BMS-470539 on lipopolysaccharide-induced neutrophil activation

Lee S, Ju W, Tin TD, Kim J, Lee JS, Park CH, Kwak SH

Background: BMS-470539, a recently introduced selective agonist of the melanocortin 1 receptor, is known to have anti-inflammatory properties. In this study, we investigated the effects of BMS-470539 on lipopolysaccharide (LPS)-induced...
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The Effects of Flecainide Acetate on Inflammatory-Immune Response in Lipopolysaccharide-Stimulated Neutrophils and on Mortality in Septic Rats

Chung SY, Kim J, Bae HB, Tin TD, Ju W, Kwak SH

BACKGROUND: Flecainide acetate is a drug used primarily for cardiac arrhythmia. Some studies also imply that flecainide acetate has the potential to regulate inflammatory-immune responses; however, its mechanism of action...
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The effects of BMS-470539 on lipopolysaccharide-induced acute lung injury

Jang EA, Kim JY, Tin TD, Song JA, Lee SH, Kwak SH

BACKGROUND: Overactivation of inflammatory cells, including macrophages and neutrophils, is associated with acute lung injury. BMS-470539 is a selective agonist of melanocortin 1 receptor, which triggers the inhibition of proinflammatory...
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