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Peripheral Nerve Axon Involvement in Myotonic Dystrophy Type 1, Measured Using the Automated Nerve Excitability Test

Bae JS, Kim SG, Lim JC, Chung EJ, Kim OK

BACKGROUND AND PURPOSE: Primary involvement of the peripheral nerves in myotonic dystrophy type I (MyD1) is controversial. We investigated whether the involvement of peripheral nerves is a primary event of...
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Zinc Inhibits Amyloid beta Production from Alzheimer's Amyloid Precursor Protein in SH-SY5Y Cells

Lee J, Kim CH, Kim DG, Ahn YS

Zinc released from excited glutamatergic neurons accelerates amyloid beta (A beta) aggregation, underscoring the therapeutic potential of zinc chelation for the treatment of Alzheimer's disease (AD). Zinc can also alter...
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Therapeutic Difficulties in Poorly Differentiated and Undifferentiated Thyroid Cancer

Lee J, Soh EY

  • KMID: 2198456
  • J Korean Thyroid Assoc.
  • 2011 Nov;4(2):87-93.
Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) have poor prognosis and rare incidence compared to well differentiate thyroid cancer. Since the original description of PDTC in 1983,...
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Human Cytomegalovirus Induces Intercellular Adhesion Molecule-1 Expression in a Monocytic Cell Line, THP-1

Kim MS, Yi HA, Lee CH

It has been reported that inflammatory diseases such as pneumonitis, retinitis, and hepatitis are associated with human cytomegalovirus (HCMV). Intercellular adhesion molecule (ICAM)-1 is an important inflammatory mediator, helping monocytes...
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The Relaxing Effect of alpha-Defensin 1 on the Adrenergic Responses of Rat Bladder

Lee SY, Kim DK, Kim KD, Myung SC, Lee MY

Defensins, cysteine-rich cationic polypeptides released from neutrophils, are known to have powerful antimicrobial properties. In this study, we sacrificed 30 rats to investigate the effects of alpha-defensin 1 on detrusor...
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Pyrrolidine Dithiocarbamate Inhibits Nuclear Factor kappaB and Toll-Like Receptor 4 Expression in Rats with Acute Necrotizing Pancreatitis

Xu M, Wang KN, Wu K, Wang XP

BACKGROUND/AIMS: To investigate the expression of Toll-like receptor 4 (TLR4) in the pancreases of rats with acute necrotizing pancreatitis (ANP) and any changes upon treatment with pyrrolidine dithiocarbamate (PDTC), an...
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Preconditioning of isoflurane on spinal cord ischemia can increase the number of inducible nitric oxide synthase-expressing motor neurons in rat

Sung YH, Lee SH, Sung JK, Han JH, Kim H, Kim CJ, Kang JM

BACKGROUND: Spinal cord ischemia with resulting paraplegia remains one of the most common complications after repair of thoracoabdominal aortic aneurysms or dissection. Inducible nitric oxide synthase (iNOS) is known to...
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TNF-alpha-induced Increase of Human beta-defensin-2 Expression in HaCaT Cell Lines

Park YD, Lee KS

  • KMID: 2248097
  • Korean J Dermatol.
  • 2008 Jul;46(7):867-873.
BACKGROUND: Several kinds of epithelial cells and focal lymph nodes are known to be involved in the skin's immune reaction. Especially, internal antimicrobial peptide play an important role in protecting...
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Effects of all-trans retinoic acid on expression of Toll-like receptor 5 on immune cells

Kim KH, Park SJ

  • KMID: 2328585
  • J Korean Assoc Oral Maxillofac Surg.
  • 2010 Dec;36(6):481-489.
INTRODUCTION: TLR-5, a member of the toll-like receptor (TLR) family, is a element of the type I transmembrane receptors, which are characterized by an intracellular signaling domain homolog to the...
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Corn silk induces nitric oxide synthase in murine macrophages

Kim KA, Choi SK, Choi HS

  • KMID: 1103321
  • Exp Mol Med.
  • 2004 Dec;36(6):545-550.
Corn silk has been purified as an anticoagulant previously and the active component is a polysaccharide with a molecular mass of 135 kDa. It activates murine macrophages to induce nitric...
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Direct Detection of Reactive Nitrogen Species in Experimental Autoimmune Uveitis

Bae SR, Wu GS, Sevanian A, Schultz BE, Zamir E, Rao NA

PURPOSE: Demonstrate unequivocally the generation of nitric oxide in experimental autoimmune uveoretinitis by electron spin resonance spectroscopy (ESR) using ferrous iron complex of N-methyl-D-glucamine dithiocarbamate, (MGD)2-Fe2+, as a spin...
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Inhibition of NF-kappaB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells

Jeong IK, Oh DH, Park SJ, Kang JH, Kim S, Lee MS, Kim MJ, Hwang YC, Ahn KJ, Chung HY, Chae MK, Yoo HJ

Recent epidemiologic studies clearly showed that early intensive glucose control has a legacy effect for preventing diabetic macrovascular complications. However, the cellular and molecular processes by which high glucose leads...
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