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A Case of Acromegaly Presenting with Diabetic Ketoacidosis

Kim JD, Sohn TS, Lee JI, Hah JH, Jung YH, Lee JM, Nam SM, Lee SW, Son HS

In patients with acromegaly, glucose intolerance and diabetes mellitus are one of the frequent manifestations. And the type of diabetes in these patients is usually non-insulin dependent type secondary to...
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Rho-kinase and Insulin Signaling

Kim YB

Insulin's ability to acutely stimulate glucose uptake and metabolism in peripheral tissues is essential for normal glucose homeostasis. Resistance to this insulin effect is a major pathogenic feature of type...
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Value of Coronary Calcium Score in Type 2 Diabetics

Lee JE, Eun MJ, Chun KA, Kim JH, Yoon JS, Cho IH, Won KC, Lee HW

BACKGROUND: Cardiovascular disease including coronary heart disease (CHD) is the most common cause of morbidity and mortality in patients with diabetes. But traditional risk factor assessment is limited to predict...
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Efficacy Evaluation of Atorvastatin in Korean Hyperlipidemic Patients with Type 2 Diabetes Mellitus

Choi DS, Kim DK, Kim DM, Kim SY, Nam MS, Park YS, Shon HS, Ahn CW, Lee KW, Lee KU, Lee MK, Chung CH, Cha BY, 83 Investigators

BACKGROUND: NCEP ATP III Guideline recommends aggressive treatments of diabetic dyslipidemia, recognizing diabetes mellitus as CHD risk equivalents. This study was conducted to evaluate the effectiveness and safety of atorvastatin...
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Glucose Oxidation and Production of Reactive Oxygen Species (ROS) in INS-1 Cells and Rat Islet Cells Exposed to High Glucose

Yoon JS, Won KC, Lee HW

BACKGROUND: Chronic exposure of pancreatic islets to supraphysiologic concentrations of glucose causes beta cell dysfunction that is a process known as glucose toxicity. It has been reported that hyperglycemia increases...
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Long-term Effect of Pioglitazone Treatment in Patients with Type 2 Diabetes

Moon JH, Kim HJ, Kim SK, Shim WS, Kang ES, Rhee Y, Ahn CW, Lim SK, Kim KR, Lee HC, Cha BS

BACKGROUND: Type 2 diabetes is characterized by impaired insulin secretion and/or insulin resistance. Thiazolidinediones have been shown to ameliorate insulin resistance. The purpose of the present study was to evaluate...
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Prevalence of Metabolic Syndrome in Young Korean Women with Polycystic Ovary Syndrome

Lee H, Oh JY, Hong Y, Sung YA, Chung H

BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and consequent hyperinsulinemia. Insulin resistance plays an important role in the development of metabolic syndrome (MS). We conducted a cross-sectional...
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Usefulness of Insulin Sensitivity Indexes derived from Oral Glucose Tolerance Test in Women with Polycystic Ovary Syndrome

Kim HJ, Byun EK, Oh JY, Sung YA, Chung HW

BACKGROUND: Insulin resistance is prevalent in women with polycystic ovary syndrome (PCOS), and it makes them to have high risk for development of type 2 diabetes. Evaluation of insulin sensitivity...
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The Effect of High Glucose and TGF-beta on the Cellular Injury in Cultured Glomerular Epithelial Cells

Jeong GH, Chung SC, Jung ED, Doh YJ, Kim HK, Park SH, Park IH, Kim JG, Ha SW, Kim BW, Lee IK, Ko CW

BACKGROUND: The glomerulus is a complex physiological structure, as well as selective filtration barrier in the control of renal blood flow and blood pressure. Glomerular epithelial cells may play an...
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