J Korean Diabetes Assoc.  2006 Jul;30(4):285-291. 10.4093/jkda.2006.30.4.285.

Prevalence of Metabolic Syndrome in Young Korean Women with Polycystic Ovary Syndrome

• Lee H
• Oh JY
• Hong Y
• Sung YA
• Chung H

• KMID: 2177600
• DOI: http://doi.org/10.4093/jkda.2006.30.4.285

Abstract

BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and consequent hyperinsulinemia. Insulin resistance plays an important role in the development of metabolic syndrome (MS). We conducted a cross-sectional study to determine the prevalence of the MS and whether the insulin resistance or hyperandrogenemia is related to the MS in young Korean women with PCOS.
METHODS
143 women with PCOS (mean age 26+/-5 years) were studied to evaluate the prevalence of MS by modified Adult Treatment Panel III. Insulin sensitivity was evaluated by euglycemic hyperinsulinemic clamp technique.
RESULTS
The prevalence of MS in women with PCOS was 11.9%, 2.8-fold higher than age matched women in Korean urban population. The most frequent component of MS was low HDL cholesterol (39.4%), and the least frequent one was high fasting serum glucose levels (6.7%). The frequency of MS was 40.7% in obese PCOS (BMI > or = 25 kg/m2, n = 38), 10.0% in overweight PCOS (BMI 23~24.9 kg/m2, n = 13), and 0% in lean PCOS (BMI < 23 kg/m2, n = 92). The frequency of MS was 26.1% in insulin resistant PCOS (insulin mediated glucose uptake, IMGU < lowest 10th percentile of lean controls, n = 65), whereas no one had MS in insulin sensitive PCOS (IMGU > or = lowest 10th percentile of lean controls, n = 78).
CONCLUSION
MS is frequent in young women with PCOS, and obesity and insulin resistance might be essential for the development of MS in this study group.

Keyword

Metabolic syndrome; PCOS

MeSH Terms

Adult
Blood Glucose
Cholesterol, HDL
Cross-Sectional Studies
Fasting
Female
Glucose
Humans
Hyperinsulinism
Insulin
Insulin Resistance
Obesity
Overweight
Polycystic Ovary Syndrome*
Prevalence*
Urban Population
Cholesterol, HDL
Glucose
Insulin

Figure

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  Fig. 1 Prevalence of metabolic syndrome among women with polycystic ovary syndrome and age-matched women in Korean urban population.

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  Fig. 2 Prevalence of isolated component of metabolic syndrome among women with PCOS and age-matched women in Korean urban population. Waist, > 80 cm; IFG, impaired fasting glucose ≥ 110 mg/dL; BP, blood pressure ≥ 130/85 mmHg; TG, triglyceride ≥ 150 mg/dL; HDL, HDL cholesterol < 50 mg/dL.

• 

  Fig. 3 Prevalence of metabolic syndrome by obesity and insulin resistance.

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