- Phosphorylation of ribosomal protein S6 and its regulation during differentiation of human leukemic cells
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Kim IS, Lee SB, Cho KC
- KMID: 1422012
- J Korean Med Sci.
- 1993 Dec;8(6):413-419.
- doi: 10.3346/jkms.1993.8.6.413
We attempted to study the role of protein tyrosine kinase (PTK) and protein kinase C (PKC) in the cascade of phosphorylation of ribosomal protein S6 during differentiation of leukemic cells... -
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- Requirements for in vitro growth of human thymocytes
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Park SH, Bae YM, Park WS, Kim TJ, Chung DH, Song HG, Cho BJ, Kim CW, Lee SK
- KMID: 1421859
- J Korean Med Sci.
- 1991 Sep;6(3):224-233.
- doi: 10.3346/jkms.1991.6.3.224
Since it is difficult to study human thymocyte maturation in vitro, we have developed an in vitro thymocyte culture system which has allowed us to select the optimal growth conditions... -
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- Regulation of fibronectin gene expression by cyclic AMP and phorbol myristate acetate in HT-1080 human fibrosarcoma cells
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Lee BH, Park RW, Kim IS
- KMID: 755015
- Exp Mol Med.
- 1998 Dec;30(4):240-245.
We studied the regulation of fibronectin (FN) gene expression by cAMP and phorbol-12-myristate-13-acetate (PMA) in HT-1080 human fibrosarcoma cells. Dibutyryl cAMP increased FN synthesis and mRNA levels, while PMA inhibited... -
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- Selective inhibition of polymorphonuclear leukocytes by immunosuppressive concentration of prostaglandin E2
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Hong YS
- KMID: 932125
- J Korean Med Sci.
- 1996 Feb;11(1):8-16.
- doi: 10.3346/jkms.1996.11.1.8
Prostaglandin E2(PGE2) has been implicated as an immunosuppressive agent and plasma levels of PGE2 are elevated in patients sustaining thermal injury. We examined the effect of 10(-7) M prostaglandin E2(PGE2)... -
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- Calyculin A modulates activation of the NADPH-oxidase in Me2SO-differentiated HL-60 cells
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Park JI, Uhlinger D, Chung BS, Kim IH, Kwak JY
- KMID: 755011
- Exp Mol Med.
- 1998 Dec;30(4):214-220.
Human promyelocytic leukemia cells (HL-60) have been used as a model system in which to study the effects of protein phosphatase inhibitors on NADPH-oxidase activation. Since O2- is generated by... -
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- Cross-linking of CD4 induces cytoskeletal association of CD4 and p56lck
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Ha-Lee YM, Lee YS, Kim YK, Sohn JW
- KMID: 927129
- Exp Mol Med.
- 2000 Mar;32(1):18-22.
A membrane glycoprotein CD4 functions as a co-receptor of a T lymphocyte. The co-receptor function has been attributed to a protein tyrosine kinase, p56lck, which is activated upon CD4 binding... -
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- Varying Effects of Intravenous Immunoglobulin on Mononuclear Cell Proliferation In Vitro
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Lee KY, Koh DK, Lee JS, Whang KT
- KMID: 2157559
- J Korean Med Sci.
- 2001 Oct;16(5):544-548.
- doi: 10.3346/jkms.2001.16.5.544
Intravenous immunoglobulin (IVIG) is being increasingly used to treat numerous immune-mediated diseases. However, there is a paucity of knowledge on the specific mode of action of IVIG in vivo. In... -
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- Major house dust mite allergen, Der p I, activates phospholipase D in human peripheral blood mononuclear cells from allergic patients: involvement of protein kinase C
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Oh JW, Kim JH, Lee KS, Han JS
- KMID: 1109304
- Exp Mol Med.
- 2000 Jun;32(2):67-71.
The major house-dust-mite allergen, Der p I, stimulates the phospholipase D (PLD) in peripheral blood mononuclear cells (PBMC) from allergic patients with maximal responses after 30 min exposure. At 30... -
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- Protein kinase C modulates telomerase activity in human cervical cancer cells
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Kim YW, Hur SY, Kim TE, Lee JM, Namkoong S, Ki IK, Kim JW
- KMID: 938880
- Exp Mol Med.
- 2001 Sep;33(3):156-163.
Telomerase, a ribonucleoprotein reverse transcriptase that extends telomeres of eukaryotic chromosomes is repressed in normal somatic cells but is activated during development and neoplasia. The regulation mechanism of telomerase activity... -
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- The p38 mitogen-activated protein kinase is involved in stress-induced phospholipase D activation in vascular smooth muscle cells
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Min DS, Shin EY, Kim EG
- KMID: 1093596
- Exp Mol Med.
- 2002 Mar;34(1):38-46.
Oxidative stress has been implicated in mediation of vascular disorders. Earlier study showed that the exposure of vascular smooth muscle cells (VSMC) to pervanadate (hydrogen peroxide plus orthovanadate) resulted in... -
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- Responsive site on the thrombospondin-1 promotor to down-regulation by phorbol 12-myristate 13-acetate in porcine aortic endothelial cells
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Kim SA, Hong KJ
- KMID: 755077
- Exp Mol Med.
- 2000 Sep;32(3):135-140.
Thrombospondin-1 (TSP-1), a multifunctional extracellular matrix protein, inhibits neovascularization and is implicated in the regression of tumor growth and metastasis. We found that the synthesis of TSP-1 in... -
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- Cell-type specific regulation of thrombospondin-1 expression and its promoter activity by regulatory agents
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Kim SA, Kang JH, Cho IH, Bae SW, Hong KJ
- KMID: 938874
- Exp Mol Med.
- 2001 Sep;33(3):117-123.
Thrombospondin-1 (TSP-1), a multifunctional protein that is able to function as a negative regulator of solid tumor progression and angiogenesis, is normally present at a very low level but rapidly... -
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- Tyrosine phosphatase and cytochrome P450 activity are critical in regulating store-operated calcium channels in human fibroblasts
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Lee KM
- KMID: 1115949
- Exp Mol Med.
- 2006 Dec;38(6):703-717.
Diverse signaling pathways have been proposed to regulate store-operated calcium entry (SOCE) in a wide variety of cell types. However, it still needs to be determined if all of these... -
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- Cyclooxygenase-2 Expression Is Related to the Epithelial-to-Mesenchymal Transition in Human Colon Cancers
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Jang TJ, Jeon KH, Jung KH
- KMID: 1777097
- Yonsei Med J.
- 2009 Dec;50(6):818-824.
- doi: 10.3349/ymj.2009.50.6.818
PURPOSE: Down-regulation of E-cadherin is a hallmark of the epithelial-to-mesenchymal transition (EMT). EMT progression in cancer cells is associated with the loss of certain epithelial markers and the acquisition of... -
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- Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells
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Ahn BH, Min G, Bae YS, Bae YS, Min DS
- KMID: 1105277
- Exp Mol Med.
- 2006 Feb;38(1):55-62.
Elevated expression of protein casein kinase II (CKII) stimulated basal phospholipase D (PLD) activity as well as PMA-induced PLD activation in human U87 astroglioma cells. Moreover, CKII-selective inhibitor, emodin and... -
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- Downstream components of RhoA required for signal pathway of superoxide formation during phagocytosis of serum opsonized zymosans in macrophages
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Kim JS, Kim JG, Jeon CY, Won HY, Moon MY, Seo JY, Kim JI, Kim J, Lee JY, Choi SY, Park J, Yoon Park , Ha KS, Kim PH, Park JB
- KMID: 1116203
- Exp Mol Med.
- 2005 Dec;37(6):575-587.
Rac1 and Rac2 are essential for the control of oxidative burst catalyzed by NADPH oxidase. It was also documented that Rho is associated with the superoxide burst reaction during phagocytosis... -
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