- Virulent Treponema pallidum 47 kDa antigen regulates the expression of cell adhesion molecules and binding of T-lymphocytes to cultured human dermal microvascular endothelial cells
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Lee KH, Choi HJ, Lee MG, Lee JB
- KMID: 1062242
- Yonsei Med J.
- 2000 Oct;41(5):623-633.
- doi: 10.3349/ymj.2000.41.5.623
Perivasculitis and endothelial cell abnormalities are prominent histopathologic features of syphilis. Various cutaneous lesions are the main clinical features of syphilis. We examined whether Treponema pallidum 47 kDa antigen regulates... -
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- Suppression of NF-kappaB activation in normal T cells by supernatant fluid from human renal cell carcinomas
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Kim HJ, Park JK, Kim YG
- KMID: 646309
- J Korean Med Sci.
- 1999 Jun;14(3):299-303.
- doi: 10.3346/jkms.1999.14.3.299
T lymphocytes from patients with renal cell carcinoma (RCC) show reduced immune function and impaired activation of the transcription factor, NF-kappaB. We determined the mechanism of NF-kappaB suppression in T... -
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- Activation of monocytes, T-lymphocytes and plasma inflammatory markers in angina patients
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Lee WH, Lee Y, Kim JR, Chu JA, Lee SY, Jung JO, Kim JS, Kim S, Seo JD, Rhee SS, Park JE
- KMID: 755045
- Exp Mol Med.
- 1999 Sep;31(3):159-164.
Inflammation and activation of immune cells have important roles in the pathogenesis of atherosclerosis. We analyzed the plasma levels of inflammatory markers and the degree of activation of peripheral blood monocytes and T-lymphocytes... -
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- Nuclear factor of activated T cells negatively regulates expression of the tumor necrosis factor receptor-related 2 gene in T cells
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Kim WK, Sul OJ, Kwak JS, Hur HY, Latour AM, Koller BH, Kwon BS, Jeong CS
- KMID: 1115264
- Exp Mol Med.
- 2010 Dec;42(12):805-810.
- doi: 10.3858/emm.2010.42.12.083
Tumor necrosis factor receptor-related 2 (TR2, HVEM or TNFRSF-14) plays an important role in immune responses, however, the mechanisms regulating its expression are unclear. To understand the control of TR2... -
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- HIV-Specific Cellular Immune Responses Are Stimulated by Structured Treatment Interruption in Chronically HIV-1 Infected Koreans
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Choi JY, Song YG, Park YS, Yoon HJ, Kim MS, Kim YK, Shin SY, Kim JM
- KMID: 1110757
- Yonsei Med J.
- 2006 Apr;47(2):282-286.
- doi: 10.3349/ymj.2006.47.2.282
We evaluated the enhancing effect of structured treatment interruptions (STIs) on HIV-specific immunity in chronically HIV-1 infected Korean patients. A prospective case-control study was done with a total of 10... -
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- Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas
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Lee H
- KMID: 1093618
- Exp Mol Med.
- 2003 Oct;35(5):448-453.
Breast cancer susceptibility gene, BRCA2, is a tumor suppressor and individuals who inherit one defected copy of BRCA2 allele experience early onset breast cancer or ovarian cancer accompanied by the... -
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- The Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein, a toll-like receptor 4 agonist, enhances dendritic cell-based cancer vaccine potency
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Noh KT, Shin SJ, Son KH, Jung ID, Kang HK, Lee SJ, Lee EK, Shin YK, You JC, Park YM
- KMID: 1383795
- Exp Mol Med.
- 2012 May;44(5):340-349.
In this study, we showed the direct interaction between Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein (FAP) and toll-like receptor4 (TLR4) via co-localization and binding by using confocal microscopy and... -
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- Bystander-Mediated Regression of Murine Neuroblastoma via Retroviral Transfer of the HSV-TK Gene
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Cho HS, Lee HR, Kim MK
- KMID: 1785703
- J Korean Med Sci.
- 2004 Feb;19(1):107-112.
- doi: 10.3346/jkms.2004.19.1.107
Selective introduction of genes conferring chemosensitivity into proliferating tumor cells may be used to treat cancer. We investigated the bystander effect of retrovirusmediated gene transfer of herpes simplex virus thymidine... -
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- Immunosuppression of xenograft rejection in porcine kidney PK15 cells by porcine IL-18
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Choi YS, Kim YK, Shim JH, Kim EM, Kang HS, Yoon DY, Muneta Y, Myung PK
- KMID: 1098092
- Exp Mol Med.
- 2006 Oct;38(5):574-582.
Xenotransplantation, the transplantation of cells, tissues or organs between individuals of different species, would resolve the current shortage of organs, but rejection remains the major hurdle to successful xenotransplantation. In... -
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- MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis
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Lee DG, Woo JW, Kwok SK, Cho ML, Park SH
- KMID: 2154239
- Exp Mol Med.
- 2013 Apr;45(4):e20.
Myeloid-related protein (MRP)8/MRP14 is an endogenous Toll-like receptor 4 (TLR4) ligand and is abundant in synovial fluid (SF) of rheumatoid arthritis (RA) patients. Belonging to damage-associated molecular patterns, it amplifies... -
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- IL-17-deficient allogeneic bone marrow transplantation prevents the induction of collagen-induced arthritis in DBA/1J mice
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Park MJ, Park HS, Oh HJ, Lim JY, Yoon BY, Kim HY, Cho ML, Cho SG
- KMID: 1401761
- Exp Mol Med.
- 2012 Nov;44(11):694-705.
IL-17-producing CD4+ T cells (Th17) play important functions in autoimmune diseases and allograft rejection of solid organs. We examined the effects of IL 17 and its mechanism of action on... -
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- Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence
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Ju YJ, Lee KH, Park JE, Yi YS, Yun MY, Ham YH, Kim TJ, Choi HM, Han GJ, Lee JH, Lee J, Han JS, Lee KM, Park GH
- KMID: 1115947
- Exp Mol Med.
- 2006 Dec;38(6):686-693.
The gradual loss of telomeric DNA can contribute to replicative senescence and thus, having longer telomeric DNA is generally considered to provide a longer lifespan. Maintenance and stabilization of telomeric... -
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- Phenotypic Characteristics of PD-1 and CTLA-4 Expression in Symptomatic Acute Hepatitis A
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Cho H, Kang H, Kim CW, Kim HY, Jang JW, Yoon SK, Lee CD
- KMID: 2363975
- Gut Liver.
- 2016 Mar;10(2):288-294.
- doi: 10.5009/gnl14368
BACKGROUND/AIMS: The immunoregulatory molecules programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) are associated with the dysfunction of antiviral effector T-cells, which leads to T-cell exhaustion and... -
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- Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells
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Kim HJ, Kim MH, Byon YY, Park JW, Jee Y, Joo HG
- KMID: 1104234
- J Vet Sci.
- 2007 Mar;8(1):39-44.
- doi: 10.4142/jvs.2007.8.1.39
An acidic polysaccharide of Panax ginseng (APG), so called ginsan is known to have important immunomodulatory activities. It was recently reported that APG has radioprotective effects in mice but the... -
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