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Unique features of bovine lymphocytes exposed to a staphylococcal enterotoxin

Park YH, Lee SU, Ferens WA, Samuels S, Davis WC, Fox LK, Ahn JS, Seo KS, Chang BS, Hwang SY, Bohach GA

We previously demonstrated that stimulation of bovine peripheral blood mononuclear cells (PBMCs) with staphylococcal enterotoxin C (SEC), led to an inversion of the CD4(+):CD8(+) T cell ratio and generation of...
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Attenuation of airway inflammation by simvastatin and the implications for asthma treatment: is the jury still out?

Liu JN, Suh DH, Yang EM, Lee SI, Park HS, Shin YS

Although some studies have explained the immunomodulatory effects of statins, the exact mechanisms and the therapeutic significance of these molecules remain to be elucidated. This study not only evaluated the...
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Regulation of B cell activating factor (BAFF) receptor expression by NF-kappaB signaling in rheumatoid arthritis B cells

Woo YJ, Yoon BY, Jhun JY, Oh HJ, Min S, Cho ML, Park SH, Kim HY, Min JK

B cells play an important role in the pathogenesis of rheumatoid arthritis (RA). High levels of B cell activating factor (BAFF) are detected in autoimmune diseases. BAFF and BAFF receptor...
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Attenuation of Peripheral Regulatory T-Cell Suppression of Skin-Homing CD8+T Cells in Atopic Dermatitis

Zhang BX, Lyu JC, Liu HB, Feng DQ, Zhang DC, Bi XJ, Duan ZW, Ding G

PURPOSE: Cutaneous lymphocyte-associated antigen (CLA)-expressing CD8+T cells have been known to play an important role in the pathogenesis of atopic dermatitis (AD). However, the mechanisms underlying the loss of self-tolerance...
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Immunostimulatory effects of anionic alkali mineral complex solution Barodon in porcine lymphocytes

Yoo BW, Choi SI, Kim SH, Yang SJ, Koo HC, Seo SH, Park BK, Yoo HS, Park YH

  • KMID: 1103501
  • J Vet Sci.
  • 2001 Apr;2(1):15-24.
The anionic alkali mineral complex solution, Barodon (Barodon-S.F. Corp., Korea), was evaluated for its effectiveness as a nonspecific immunostimulator in pigs. The effects of Barodon were determined by analysis of...
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Prevention of chronic graft-versus-host disease by stimulation with glucocorticoid-induced TNF receptor

Kim J, Choi WS, Kim HJ, Kwon B

  • KMID: 1105281
  • Exp Mol Med.
  • 2006 Feb;38(1):94-99.
GITR (glucocorticoid-induced TNF receptor) is a recently identified member of the TNF receptor superfamily. The receptor is preferentially expressed on CD4+CD25+ regulatory T cells and GITR signals break the suppressive...
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A comparison study on allergen components between Korean (Arachis fastigiata Shinpung) and American peanut (Arachis hypogaea Runner)

Park CW, Kim GI, Lee CH

The prevalence of peanut allergy in Korea is lower than in America. Peanut extract allergens between the two countries have not been standardized. This study was performed to compare the...
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Molecular analysis of hprt mutation in B6C3F1 mice exposed to ozone alone and combined treatment of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate for 32 and 52 weeks

Kim MY, Kim HW, Park JH, Kim JS, Jin H, Moon SH, Eu KJ, Cho HS, Kang G, Kim YS, Kim YC, Kim HY, Lee KH, Cho MH

  • KMID: 1093634
  • J Vet Sci.
  • 2004 Dec;5(4):379-385.
Potential toxicological interactions of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and/or dibuthyl phthalate (DBP) on ozone were investigated after 32- and 52-wk exposures using hprt mutation assay. Male and female B6C3F1 mice exposed to...
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Upregulation of CD47 in Regulatory T Cells in Atopic Dermatitis

Lee N, Shin JU, Jin S, Yun KN, Kim JY, Park CO, Kim SH, Noh JY, Lee KH

PURPOSE: Regulatory T (Treg) cells are key modulators in the immune system. Recent studies have shown that atopic dermatitis (AD) patients have higher numbers of Treg cells; however, little is...
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Kinetics of T-cell-based assays on cerebrospinal fluid and peripheral blood mononuclear cells in patients with tuberculous meningitis

Park KH, Lee MS, Lee SO, Choi SH, Kim YS, Woo JH, Kang JK, Lee SA, Kim SH

BACKGROUND/AIMS: The goal of this study was to monitor tuberculosis (TB)-specific T-cell responses in cerebrospinal fluid-mononuclear cells (CSF-MCs) and peripheral blood mononuclear cells (PBMCs) in patients with tuberculous meningitis (TBM)...
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