- Familial Gitelman Syndrome in Sisters
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Hong EJ, Ha TS
- KMID: 2254136
- Korean J Nephrol.
- 2007 Jan;26(1):102-106.
Gitelman syndrome is a hereditary renal tubular disorder characterized by hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria. This syndrome is caused by the genetic mutation of SLC12A3 gene encoding thiazide-sensitive sodium-chloride... -
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- Water and Sodium Regulation in Heart Failure
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Bae EH, Ma SK
- KMID: 2052317
- Electrolyte Blood Press.
- 2009 Dec;7(2):38-41.
- doi: 10.5049/EBP.2009.7.2.38
Heart failure is the pathophysiological state characterized by ventricular dysfunction and associated clinical symptoms. Decreased cardiac output or peripheral vascular resistance lead to arterial underfilling. That is an important signal... -
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- A Case of Gitelman Syndrome
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Han YJ, Yeon EK, Kim YC
- KMID: 2317667
- Soonchunhyang Med Sci.
- 2012 Dec;18(2):145-147.
Gitelman's syndrome is an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria that has recently been reported to be linked to thiazide-sensitive Na-Cl cotransporter gene mutation. We... -
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- Lesionalized Therapy beyond Personalized Therapy in Cancer Management
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Chung JK, Kim MJ, Youn H
- KMID: 2129621
- J Korean Med Sci.
- 2014 Oct;29(10):1331-1332.
- doi: 10.3346/jkms.2014.29.10.1331
No abstract available. -
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- Altered Regulation of Renal Sodium Transporters in Salt-Sensitive Hypertensive Rats Induced by Uninephrectomy
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Jung JY, Lee JW, Kim S, Jung ES, Jang HR, Han JS, Joo KW
- KMID: 2052320
- Electrolyte Blood Press.
- 2009 Dec;7(2):58-66.
- doi: 10.5049/EBP.2009.7.2.58
Uninephrectomy (uNx) in young rats causes salt-sensitive hypertension (SSH). Alterations of sodium handling in residual nephrons may play a role in the pathogenesis. Therefore, we evaluated the adaptive alterations of... -
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- A Case of Gitelman's Syndrome Presented with Chest Pain and Syncope
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Shin HS, Park CH
- KMID: 1867705
- Korean J Nephrol.
- 2006 Nov;25(6):1013-1017.
Gitelman's syndrome is a rare autosomal recessive, inherited renal tubular disorder, first described by Gitelman et al. in 1966, and it is characterized by hypokalemic metabolic alkalosis, hypomagnesemia, salt wasting,... -
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- Ca2+ is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line
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Park S, Ku SK, Ji HW, Choi JH, Shin DM
- KMID: 1791426
- Korean J Physiol Pharmacol.
- 2015 May;19(3):249-255.
- doi: 10.4196/kjpp.2015.19.3.249
Wnk kinase maintains cell volume, regulating various transporters such as sodium-chloride cotransporter, potassium-chloride cotransporter, and sodium-potassium-chloride cotransporter 1 (NKCC1) through the phosphorylation of oxidative stress responsive kinase 1 (OSR1) and... -
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- Diagnostic and Therapeutic Approaches to Radioactive Iodine Refractory Differentiated Thyroid Cancer
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Ryu J
- KMID: 1849762
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2012 Jul;55(7):403-409.
- doi: 10.3342/kjorl-hns.2012.55.7.403
Unlike most thyroid cancers which have an excellent prognosis with standard treatments such as surgery and additional radioactive iodine therapy followed by long term TSH suppression, 15-20% of differentiated thyroid... -
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- Biochemical Characteristics of The Na-alpha-Ketoglutarate Cotransport System in Proximal Convoluted and Straight Tubules of the Rabbit Kidney
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Ahn DW, Kim KR, Park HS, Park YS
- KMID: 2254125
- Korean J Nephrol.
- 2007 Jan;26(1):5-13.
PURPOSE: alpha-Ketoglutarate (alphaKG), a Krebs cycle intermediate, is extensively used in the kidney as a fuel substrate and as a counter anion for organic acid secretion. It is known to... -
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- Gitelman syndrome combined with complete growth hormone deficiency
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Min SR, Cho HS, Hong J, Cheong HI, Ahn SY
- KMID: 1429681
- Ann Pediatr Endocrinol Metab.
- 2013 Mar;18(1):36-39.
- doi: 10.6065/apem.2013.18.1.36
Gitelman syndrome is a rare autosomal recessive hereditary salt-losing tubulopathy, that manifests as hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria. It is caused by mutations in the solute carrier family 12(sodium/chloride... -
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- RAI Treatment of Distant Metastasis of Thyroid Cancer
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Kang KW
- KMID: 1428453
- J Korean Thyroid Assoc.
- 2013 May;6(1):49-55.
- doi: 10.11106/jkta.2013.6.1.49
For the distant metastasis of differentiated thyroid cancers, such as papillary thyroid carcinoma, follicular thyroid carcinoma, and Hurthle cell carcinoma, radioiodine therapy is one of the standard treatment methods after... -
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- Expression of Occludin in Porcine Renal Epithelial Cells
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Lee SY, Han KH
- KMID: 1472503
- Korean J Anat.
- 2009 Mar;42(1):11-17.
Occludin is a cell adhesion molecule that is abundantly expressed in the kidney. However, the expression pattern in various renal epithelial cells is not well established. The purpose of this... -
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- Attenuated Renal Excretion in Response to Thiazide Diuretics in Gitelman's Syndrome: A Case Report
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Yeum CH, Kim SW, Ma SK, Ko JH, Nah MY, Kim NH, Choi KC
- KMID: 1109772
- J Korean Med Sci.
- 2002 Aug;17(4):567-570.
- doi: 10.3346/jkms.2002.17.4.567
Gitelman's syndrome is a variant of Bartter's syndrome characterized by hypocalciuria and hypomagnesemia. The administration of thiazide diuretics may induce a subnormal increase of urinary Na+ and Cl- excretion in... -
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- Sunitinib-induced hypothyroidism
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Kim SW
- KMID: 2257384
- Korean J Med.
- 2009 Jan;76(1):33-36.
Sunitinib malate is a multi-targeted tyrosine kinase inhibitor used for gastrointestinal stromal tumor and renal cell carcinoma. It is also under phase II trial for use in advanced colon cancer,... -
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- Decreased Immunoreactivities of the Chloride Transporters, KCC2 and NKCC1, in the Lateral Superior Olive Neurons of Kanamycin-treated Rats
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Suh MW, Ahn SC
- KMID: 2134593
- Clin Exp Otorhinolaryngol.
- 2012 Sep;5(3):117-121.
- doi: 10.3342/ceo.2012.5.3.117
OBJECTIVES: From our previous study about the weak expressions of potassium-chloride (KCC2) and sodium-potassium-2 chloride (NKCC1) co-transporters in the lateral superior olive (LSO) in circling mice, we hypothesized that partially... -
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- Sodium Iodide Symporter and the Radioiodine Treatment of Thyroid Carcinoma
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Chung JK, Youn HW, Kang JH, Lee HY, Kang KW
- KMID: 2051960
- Nucl Med Mol Imaging.
- 2010 Apr;44(1):4-14.
Since the specific accumulation of iodide in thyroid was found in 1915, radioiodine has been widely applied to diagnose and treat thyroid cancer. Iodide uptake occurs across the membrane of... -
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- Alpha-Lipoic Acid Decreases Iodine Uptake in the Rat Thyroid Cell Line FRTL-5
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Yim JH, Kim TY, Ruiz-Llorente S, Kim WG, Han JM, Jeon MJ, Kim WB, Shong YK
- KMID: 2198434
- J Korean Thyroid Assoc.
- 2012 May;5(1):39-44.
- doi: 10.11106/jkta.2012.5.1.39
BACKGROUND AND OBJECTIVES: Alpha-lipoic acid (ALA) is a naturally occurring fatty acid with strong antioxidant properties that exerts protective effects against harmful free radical damage. The aim of the present... -
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- The role of renal proximal tubule transport in the regulation of blood pressure
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Horita S, Nakamura M, Suzuki M, Satoh N, Suzuki A, Homma Y, Nangaku M
- KMID: 2409385
- Kidney Res Clin Pract.
- 2017 Mar;36(1):12-21.
- doi: 10.23876/j.krcp.2017.36.1.12
The electrogenic sodium/bicarbonate cotransporter 1 (NBCe1) on the basolateral side of the renal proximal tubule plays a pivotal role in systemic acid-base homeostasis. Mutations in the gene encoding NBCe1 cause... -
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- Altered Regulation of NHE3, NBC1 and Nitric Oxide System in the Kidney of Rats with Maleic Acid-nduced Metabolic Acidosis
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Ma SK
- KMID: 1597799
- Korean J Nephrol.
- 2006 Jul;25(4):543-550.
PURPOSE: The present study was aimed to determine whether there exist an altered regulation of tubular transporters and nitric oxide system in the kidneys in maleic acid-nduced metabolic acidosis. METHODS: Male... -
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- B-RafV600E inhibits sodium iodide symporter expression via regulation of DNA methyltransferase 1
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Choi YW, Kim HJ, Kim YH, Park SH, Chwae YJ, Lee J, Soh EY, Kim JH, Park TJ
- KMID: 2155385
- Exp Mol Med.
- 2014 Nov;46(11):e120.
- doi: 10.1038/emm.2014.68
B-RafV600E mutant is found in 40-70% of papillary thyroid carcinoma (PTC) and has an important role in the pathogenesis of PTC. The sodium iodide symporter (NIS) is an integral plasma... -
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