- Computational Approach for the Analysis of Post-PKS Glycosylation Step
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Kim KB, Park K
- KMID: 2166422
- Genomics Inform.
- 2008 Dec;6(4):223-226.
We introduce a computational approach for analysis of glycosylation in Post-PKS tailoring steps. It is a computational method to predict the deoxysugar biosynthesis unit pathway and the substrate specificity of... -
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- Ubiquitination of Aquaporin: in the kidney
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Lee YJ, Kwon TH
- KMID: 1464781
- Electrolyte Blood Press.
- 2009 Jun;7(1):1-4.
- doi: 10.5049/EBP.2009.7.1.1
Ubiquitination is known to be important for endocytosis and lysosomal degradation of aquaporin-2 (AQP2). Ubiquitin (Ub) is covalently attached to the lysine residue of the substrate proteins and activation and... -
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- Screening of Peptide Libraries to Investigate the Substrate Specificity of UL97 Protein Kinase from Human Cytomegalovirus
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Baek MC
- KMID: 2055018
- J Bacteriol Virol.
- 2006 Jun;36(2):119-124.
- doi: 10.4167/jbv.2006.36.2.119
Human cytomegalovirus encodes an unusual protein kinase UL97 which can phosphorylate exogenous substrates, including histone H2B and nucleoside analogs such as ganciclovir. The previous result interestingly showed that the peptides... -
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- Alteration of Substrate Specificity by Common Variants, E158K/E308G and V257M, in Human Hepatic Drug-metabolizing Enzyme, Flavin-containing Monooxygenase 3
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Lee JK, Kang JH, Cha YN, Chung WG, Park CS
- KMID: 2071590
- Korean J Physiol Pharmacol.
- 2003 Jun;7(3):157-162.
Our earlier studies found a significant correlation between the activities of ranitidine N-oxidation catalyzed by hepatic flavin-containing monooxygenase (FMO) and the presence of mutations in exon 4 (E158K) and exon... -
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- The Ubiquitin-Proteasome System and F-box Proteins in Pathogenic Fungi
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Liu TB, Xue C
- KMID: 2312649
- Mycobiology.
- 2011 Dec;39(4):243-248.
The ubiquitin-proteasome system is one of the major protein turnover mechanisms that plays important roles in the regulation of a variety of cellular functions. It is composed of E1 (ubiquitin-activating... -
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- Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif
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Kim MA, Kim HJ, Brown AL, Lee MY, Bae YS, Park JI, Kwak JY, Chung JH, Yun J
- KMID: 1094661
- Exp Mol Med.
- 2007 Apr;39(2):205-212.
Checkpoint kinase 1 (Chk1) and Chk2 are effector kinases in the cellular DNA damage response and impairment of their function is closely related to tumorigenesis. Previous studies revealed several substrate... -
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- Molecular aspects of organic ion transporters in the kidney
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Cha SH, Hitoshi E
- KMID: 2285231
- Korean J Physiol Pharmacol.
- 2001 Apr;5(2):107-122.
A function of the kidney is elimination of a variety of xenobiotics ingested and wasted endogenous compounds from the body. Organic anion and cation transport systems play important roles to protect the... -
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- Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Measurement of Leukocyte Arylsulfatase A Activity Using a Natural Substrate
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Han M, Jun SH, Song SH, Park HD, Park KU, Song J
- KMID: 2363170
- Ann Lab Med.
- 2015 Jan;35(1):165-168.
- doi: 10.3343/alm.2015.35.1.165
No abstract available. -
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- Association Study of Dopamine Transporter(DATI) G2319A Genetic Polymorphism in Alcohol Dependence
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Yang BH, Lee MG, Choi JY, Oh DY, Kim GS, Kim HT, Chia YG
- KMID: 2202805
- J Korean Soc Biol Psychiatry.
- 2001 Nov;8(2):239-245.
OBJECTIVE: Dopamine transporter is member of family of Na/Cl dependent neurotransmitter transporter, 12 transmembrane domain that has high substrate specificity, affinity. It is related with dopamine reuptake in presynaptic vesicle.... -
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- Functional characteristics of neutral amino acid transporter in opossum kidney (OK) cells
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Woo JS, Park MH, Oh SO, Jung JS, Kim YK, Lee SH
- KMID: 1554554
- Korean J Physiol Pharmacol.
- 1997 Apr;1(2):185-193.
The characteristics of Na+/-dependent cycloleucine uptake was investigated in OK cells with regard to substrate specificity and regulation by protein kinase C (PKC). Inhibition studies with different synthetic and natural amino acids showed... -
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- Evaluation of a tyrosine kinase peptide microarray for tyrosine kinase inhibitor therapy selection in cancer
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Labots M, Gotink KJ, Dekker H, Azijli K, van der Mijn JC, Huijts CM, Piersma SR, Jiménez C, Verheul HM
- KMID: 2367555
- Exp Mol Med.
- 2016 Dec;48(12):e279.
- doi: 10.1038/emm.2016.114
Personalized cancer medicine aims to accurately predict the response of individual patients to targeted therapies, including tyrosine kinase inhibitors (TKIs). Clinical implementation of this concept requires a robust selection tool.... -
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- Curcumin treatment recovery the decrease of protein phosphatase 2A subunit B induced by focal cerebral ischemia in Sprague-Dawley rats
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Shah FA, Park DJ, Gim SA, Koh PO
- KMID: 2312130
- Lab Anim Res.
- 2015 Sep;31(3):134-138.
- doi: 10.5625/lar.2015.31.3.134
Curcumin provides various biological effects through its anti-inflammatory and antioxidant properties. Moreover, curcumin exerts a neuroprotective effect against ischemic condition-induced brain damage. Protein phosphatase 2A (PP2A) is a ubiquitous serine... -
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- Immunohistochemical Expression of Placental Form of Glutathione S-transferase (GST-pi) in Fetal Skin
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Son HC, Park SR, Kim MK, Song KY
- KMID: 2303025
- Korean J Dermatol.
- 2003 Feb;41(2):167-173.
BACKGROUND: Glutathione S-transferases(GST) are a family of multi-functional enzymes involved in cellular detoxification and excretion of a variety of exogenous and endogenous toxic or carcinogenic compounds. The GST family has... -
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- Studies on rat liver nuclear DNA damaged by chemical carcinogen (3'-Me DAB) and AP DNA endonuclease. I. Purification and some properties of AP DNA endonucleases in rat liver chromatin
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Kim YS, Kim JW, Lee SE, Oh SH
- KMID: 1421490
- J Korean Med Sci.
- 1990 Sep;5(3):127-135.
- doi: 10.3346/jkms.1990.5.3.127
Three kinds of apurinic/apyrimidinic (AP) DNA endonuclease, APcI, APcII, APcIII, were purified from rat liver chromatin through 1M KCl extraction, DEAE-trisacryl ion exchange chromatography. Sephadex G-150 gel filtration and AP... -
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- Tyrosine nitration site specificity identified by LC/MS in nitrite-modified collagen type IV
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Wang Z, Paik DC, Dillon JP, Gaillard E
- KMID: 1103683
- Exp Mol Med.
- 2007 Feb;39(1):74-83.
Non-enzymatic nitrite induced collagen cross-linking results in changes reminiscent of age-related damage and parallels the well-known model system, non-enzymatic glycation. We have recently observed that nitrite modification of basement membrane... -
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- Immunohistochemical Study of Collagenase-3(Matrix Metalloproteinase-13) in Squamous Cell Carcinomas of the Head and Neck
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Rho YS, Song BC, Park IS, Lim HJ, Kim DH
- KMID: 2275851
- Korean J Otolaryngol-Head Neck Surg.
- 2002 Jan;45(1):62-68.
BACKGROUND AND OBJECTIVES: Squamous cell carcinomas (SCCs) of the head and neck are known for their aggresive growth and propensity to metastasize, which often results in poor prognosis. Tumor cell... -
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- Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases
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Patel MS, Korotchkina LG
- KMID: 1457529
- Exp Mol Med.
- 2001 Dec;33(4):191-197.
This review summarizes the recent developments on the regulation of human pyruvate dehydrogenase complex (PDC) by site-specific phosphorylation by four kinases. Mutagenic analysis of the three phosphorylation sites of human... -
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- Analysis of Acid Sphingomyelinase Activity in Dried Blood Spots Using Tandem Mass Spectrometry
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Legnini E, Orsini JJ, Muhl A, Johnson B, Dajnoki A, Bodamer OA
- KMID: 1387345
- Ann Lab Med.
- 2012 Sep;32(5):319-323.
- doi: 10.3343/alm.2012.32.5.319
BACKGROUND: Niemann Pick disease (NP) is a rare, lysosomal storage disorder due to deficiency of the intra-lysosomal enzyme acid sphingomyelinase (ASM) resulting in intracellular accumulation of sphingomyelin. We evaluated a... -
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- Cholesterol induce oligomerization of Vibrio vulnificus cytolysin specifically.
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Kim BS, Kim JS
- KMID: 1380232
- Exp Mol Med.
- 2002 Jul;34(3):239-242.
Vibrio vulnificus cytolysin (VVC) has been implicated as one of the important virulence determinants of V. vulnificus that causes serious septicemia and wound infection. An attempt was made to investigate... -
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- Lysophosphatidic acid induces cell migration through the selective activation of Akt1
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Kim EK, Yun SJ, Do KH, Kim MS, Cho M, Suh DS, Kim CD, Kim JH, Birnbaum M, Bae SS
- KMID: 1094124
- Exp Mol Med.
- 2008 Aug;40(4):445-452.
- doi: 10.3858/emm.2008.40.4.445
Akt plays pivotal roles in many physiological responses including growth, proliferation, survival, metabolism, and migration. In the current studies, we have evaluated the isoform-specific role of akt in lysophosphatidic acid... -
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