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Therapeutic time window for methylprednisolone in spinal cord injured rat

Yoon DH, Kim YS, Young W

Recent clinical trials have reported that methylprednisolone sodium succinate administered within 8 hours improves neurological recovery in human spinal cord injury (SCI). Methylprednisolone, however, was ineffective and possibly...
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Neural toxicity induced by accidental intrathecal vincristine administration

Kwack EK, Kim DJ, Park TI, Cho KR, Kwon IH, Sohn YK

Described here is a case of accidental intrathecal administration of vincristine with pathologic findings in the central nervous system. A 3-year-old boy with acute lymphoblastic leukemia, was given his ninth...
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Continuous Brain-derived Neurotrophic Factor (BDNF) Infusion After Methylprednisolone Treatment in Severe Spinal Cord Injury

Kim DH, Jahng TA

Although methylprednisolone (MP) is the standard of care in acute spinal cord injury (SCI), its functional outcome varies in clinical situation. Recent report demonstrated that MP depresses the expression of...
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Diffuse cerebrospinal gliomatosis with extensive leptomeningeal spread

Bae JY, Choi BO, SunWoo IN, Kim DI, Cho SH, Kim TS

A case of diffuse cerebrospinal gliomatosis with extensive leptomeningeal spread is presented. The patient, an 18-year-old girl, was admitted due to progressive weakness and paresthesia of both legs, following rapid...
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Unique Imaging Features of Spinal Neurenteric Cyst

Jung HS, Park SM, Kim GU, Kim MK, Song KS

A 50-year-old male presented with acutely progressed paraplegia. His magnetic resonance imaging demonstrated two well-demarcated components with opposite signals in one cystic lesion between the T1- and T2-weighted images at...
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Effects of Methylprednisolone on the Neural Conduction of the Motor Evoked Potentials in Spinal Cord Injured Rats

Lee BH, Lee KH, Yoon DH, Kim UJ, Hwang YS, Park SK, Choi JU, Park YG

Methylprednisolone (MP), a glucocorticoid steroid, has an anti-inflammatory action and seems to inhibit the formation of oxygen free radicals produced during lipid peroxidation in a spinal cord injury (SCI). However,...
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