- Neutral Sphingomyelinase and Breast Cancer Research
-
Hwang SY, Kim TH, Lee HH
- KMID: 2201018
- J Menopausal Med.
- 2015 Apr;21(1):24-27.
- doi: 10.6118/jmm.2015.21.1.24
Our understanding of the functions of neutral sphingomyelinase (N-SMase) signaling has advanced over the past decade. In this review, we focus on the roles and regulation of N-SMase 1, N-SMase... -
- CITED
-
- Close
- SHARE
-
- Close
- An Anesthetic Experience in a Patient with Niemann-Pick Disease: A case report
-
Lee JH, Jung WS, Lee HY, Kim AR, Yoon HS, Go YK
- KMID: 2236583
- Korean J Anesthesiol.
- 2008 Jan;54(1):109-112.
- doi: 10.4097/kjae.2008.54.1.109
Niemann-Pick disease (NPD) is an autosomal recessive, lipid storage disorder caused by the deficiency of the lysosomal enzyme sphingomyelinase or defective cholesterol transport from lysosome to cytosol. The clinical symptoms... -
- CITED
-
- Close
- SHARE
-
- Close
- Ceramide is Involved in MPP+ -induced Cytotoxicity in Human Neuroblastoma Cells
-
Nam EJ, Lee HS, Lee YJ, Joo WS, Maeng S, Im HI, Park CW, Kim YS
- KMID: 1615193
- Korean J Physiol Pharmacol.
- 2002 Dec;6(6):281-286.
To understand the cytotoxic mechanism of MPP+, we examined the involvement of ceramide in MPP+ -induced cytotoxicity to human neuroblastoma SH-SY5Y cells. When SH-SY5Y cells were exposed to MPP+, MPP+... -
- CITED
-
- Close
- SHARE
-
- Close
- Vitamin C Stimulates Epidermal Ceramide Production by Regulating Its Metabolic Enzymes
-
Kim KP, Shin KO, Park K, Yun HJ, Mann S, Lee YM, Cho Y
- KMID: 2380303
- Biomol Ther.
- 2015 Nov;23(6):525-530.
- doi: 10.4062/biomolther.2015.044
Ceramide is the most abundant lipid in the epidermis and plays a critical role in maintaining epidermal barrier function. Overall ceramide content in keratinocyte increases in parallel with differentiation, which... -
- CITED
-
- Close
- SHARE
-
- Close
- Comparative effect of dietary borage oil and safflower oil on anti-proliferation and ceramide metabolism in the epidermis of essential fatty acid deficient guinea pigs
-
Lee SR, Cho Y
- KMID: 2209898
- J Nutr Health.
- 2015 Aug;48(4):319-326.
- doi: 10.4163/jnh.2015.48.4.319
PURPOSE: Borage oil (BO) and safflower oil (SO) are efficacious in reversing epidermal hyperproliferation, which is caused by the disruption of epidermal barrier. In this study, we compared the antiproliferative... -
- CITED
-
- Close
- SHARE
-
- Close
- Analysis of Acid Sphingomyelinase Activity in Dried Blood Spots Using Tandem Mass Spectrometry
-
Legnini E, Orsini JJ, Muhl A, Johnson B, Dajnoki A, Bodamer OA
- KMID: 1387345
- Ann Lab Med.
- 2012 Sep;32(5):319-323.
- doi: 10.3343/alm.2012.32.5.319
BACKGROUND: Niemann Pick disease (NP) is a rare, lysosomal storage disorder due to deficiency of the intra-lysosomal enzyme acid sphingomyelinase (ASM) resulting in intracellular accumulation of sphingomyelin. We evaluated a... -
- CITED
-
- Close
- SHARE
-
- Close
- The Study on the Mechanism of Cyclosporine A-induced Nephroptoxicity: The Effects of Ceramide and Phospholipase A2 on Cyclosporine A-induced Apoptosis of Renal Tubular Epithelial Cells
-
Choi KH, Jeong HJ, Kwon HY, Kim SI
- KMID: 2324292
- J Korean Soc Transplant.
- 2002 Jun;16(1):9-15.
PURPOSE: In order to elucidate the mechanisms mediating cyclosporine A (CsA)-induced renal tubular cell injury, we examined the effects of ceramide, second messenger derived from sphingolipid breakdown, and phospholipase A2... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of sphingomyelin-MAPKs pathway in heat-induced apoptosis
-
Chung HS, Park SR, Choi EK, Park HJ, Griffin RJ, Song CW, Park H
- KMID: 1094699
- Exp Mol Med.
- 2003 Jun;35(3):181-188.
The role of sphingomyelinase (SMase) activation and mitogen activated protein kinases (MAPKs) activation in cellular apoptosis was investigated during the hyperthermic treatment of HL-60 human leukemia cells. Treating the cells... -
- CITED
-
- Close
- SHARE
-
- Close
- Differential effects of Fas cross-linking on phospholipase D activation and related lipid metabolism in Fas-resistant A20 cells.
-
Lim SY, Lee SC, Shin IC, Han JS
- KMID: 1380228
- Exp Mol Med.
- 2002 Jul;34(3):201-210.
A20 murine lymphoma cells undergoing Fas-mediated apoptosis showed increase in the activity of phospholipase D (PLD), which is involved in proliferative or mitogenic cellular responses. Using A20 cell lines that... -
- CITED
-
- Close
- SHARE
-
- Close
- A Case of a Korean Adult Affected by Type B Niemann-Pick Disease: Secondary Sea-blue Histiocytosis and Molecular Characterization
-
Cho YU, Chae JD, Lee WM, Woo JJ, Lee HB, Gong SJ, Park CJ, Kim GH, Yoo HW
- KMID: 854963
- Korean J Lab Med.
- 2009 Apr;29(2):97-103.
- doi: 10.3343/kjlm.2009.29.2.97
Niemann-Pick disease (NPD) is an inherited metabolic disorder caused by a deficiency of the enzyme acid sphingomyelinase coded by SMPD1 gene. In contrast with type A NPD, a severe neurodegenerative... -
- CITED
-
- Close
- SHARE
-
- Close
