- Spatial Learning and Memory Using a Radial Arm Maze with a Head-Mounted Display
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Kim H, Park JY, Kim K(
- KMID: 2425504
- Psychiatry Investig.
- 2018 Oct;15(10):935-944.
- doi: 10.30773/pi.2018.06.28.3
OBJECTIVE: A radial arm maze (RAM) is an essential tool for assessing spatial learning and memory. Although this tool is widely used to study deficits in spatial memory in animal... -
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- Identification of Vestibular Organ Originated Information on Spatial Memory in Mice
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Han GC, Kim M, Kim MJ
- KMID: 2436244
- Res Vestib Sci.
- 2018 Dec;17(4):134-141.
- doi: 10.21790/rvs.2018.17.4.134
OBJECTIVES: We aimed to study the role of vestibular input on spatial memory performance in mice that had undergone bilateral surgical labyrinthectomy, semicircular canal (SCC) occlusion and 4G hypergravity exposure. METHODS:... -
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- Linalool Ameliorates Memory Loss and Behavioral Impairment Induced by REM-Sleep Deprivation through the Serotonergic Pathway
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Lee BK, Jung AN, Jung YS
- KMID: 2420387
- Biomol Ther.
- 2018 Jul;26(4):368-373.
- doi: 10.4062/biomolther.2018.081
Rapid eye movement (REM) sleep has an essential role in the process of learning and memory in the hippocampus. It has been reported that linalool, a major component of Lavandula... -
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- Effects of (−)-Sesamin on Memory Deficits in MPTP-lesioned Mouse Model of Parkinson's Disease
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Zhao TT, Shin KS, Lee MK
- KMID: 2366691
- Nat Prod Sci.
- 2016 Dec;22(4):246-251.
- doi: 10.20307/nps.2016.22.4.246
This study investigated the effects of (−)-sesamin on memory deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD). MPTP lesion (30 mg/kg/day, 5 days) in mice showed memory deficits... -
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- Differential Effects of Pentoxifylline on Learning and Memory Impairment Induced by Hypoxic-ischemic Brain Injury in Rats
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Halis H, Bitiktaş , Baştuğ O, Tan B, Kavraal S, Güneş T, Süer C
- KMID: 2457402
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):388-399.
- doi: 10.9758/cpn.2019.17.3.388
OBJECTIVE: Hypoxic-ischemic (HI) brain injury in the human perinatal period often leads to significant long-term neurobehavioral dysfunction in the cognitive and sensory-motor domains. Using a neonatal HI injury model (unilateral... -
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- Effect of Ghrelin on Memory Impairment in a Rat Model of Vascular Dementia
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Park JM, Kim YJ
- KMID: 2451299
- J Korean Acad Nurs.
- 2019 Jun;49(3):317-328.
- doi: 10.4040/jkan.2019.49.3.317
PURPOSE: The purpose of this study was to identify the effect of ghrelin on memory impairment in a rat model of vascular dementia induced by chronic cerebral hypoperfusion. METHODS: Randomized controlled... -
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- Effects of Chronic and Acute Lithium Treatment on the Long-term Potentiation and Spatial Memory in Adult Rats
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Yousef M, Kavraal Å, Artış AS, Süer C
- KMID: 2456726
- Clin Psychopharmacol Neurosci.
- 2019 Mar;17(2):233-243.
- doi: 10.9758/cpn.2019.17.2.233
OBJECTIVE: Although, accumulating evidence is delineating a neuroprotective and neurotrophic role for lithium (Li), inconsistent findings have also been reported in human studies especially. Moreover, the effects of Li infusion... -
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- Pre-Mild Cognitive Impairment: Can Visual Memory Predict Who Rapidly Convert to Mild Cognitive Impairment?
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Seo EH, Kim H, Choi KY, Lee KH, Choo IH
- KMID: 2424019
- Psychiatry Investig.
- 2018 Sep;15(9):869-875.
- doi: 10.30773/pi.2018.07.29.1
OBJECTIVE: Little is known about the natural course of pre-mild cognitive impairment (pre-MCI) and predictors to MCI. We followed-up individuals with pre-MCI and cognitively normal (CN) elders to identify neuropsychological... -
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- Segregated Cell Populations Enable Distinct Parallel Encoding within the Radial Axis of the CA1 Pyramidal Layer
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Geiller T, Royer S, Choi JS
- KMID: 2368650
- Exp Neurobiol.
- 2017 Feb;26(1):1-10.
- doi: 10.5607/en.2017.26.1.1
Numerous studies have implicated the hippocampus in the encoding and storage of declarative and spatial memories. Several models have considered the hippocampus and its distinct subfields to contain homogeneous pyramidal... -
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- Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and c-Raf/MEK/ERK Pathways in Hippocampus
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Shin MS, Kim TW, Park SS, Ko IG, Kim CJ, Kim M, Roh SY, Kim KT, Kim KH
- KMID: 2452559
- Int Neurourol J.
- 2019 Jun;23(2):116-124.
- doi: 10.5213/inj.1938103.052
PURPOSE: Goserelin is a drug used for chemical castration. In a rat model, we investigated whether surgical and chemical castration affected memory ability through the protein kinase A (PKA)/cyclic adenosine... -
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- Exploratory, cognitive, and depressive-like behaviors in adult and pediatric mice exposed to controlled cortical impact
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Lee SW, Jang MS, Jeong SH, Kim H
- KMID: 2452985
- Clin Exp Emerg Med.
- 2019 Jun;6(2):125-137.
- doi: 10.15441/ceem.18.019
OBJECTIVE: Sequelae of behavioral impairments associated with human traumatic brain injury (TBI) include neurobehavioral problems. We compared exploratory, cognitive, and depressive-like behaviors in pediatric and adult male mice exposed to... -
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- Differential Effects of Olanzapine and Haloperidol on MK-801-induced Memory Impairment in Mice
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Song JC, Seo MK, Park SW, Lee JG, Kim YH
- KMID: 2348476
- Clin Psychopharmacol Neurosci.
- 2016 Aug;14(3):279-285.
- doi: 10.9758/cpn.2016.14.3.279
OBJECTIVE: We investigated the differential effects of the antipsychotic drugs olanzapine and haloperidol on MK-801-induced memory impairment and neurogenesis in mice. METHODS: MK-801 (0.1 mg/kg) was administered 20 minutes prior to... -
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- Dehydroevodiamine·HCl enhances cognitive function in memory-impaired rat models
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Shin KY, Kim KY, Suh YH
- KMID: 2371068
- Korean J Physiol Pharmacol.
- 2017 Jan;21(1):55-64.
- doi: 10.4196/kjpp.2017.21.1.55
Progressive memory impairment such as that associated with depression, stroke, and Alzheimer's disease (AD) can interfere with daily life. In particular, AD, which is a progressive neurodegenerative disorder, prominently features... -
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- Effect of Environmental Enrichment on Cognitive Impairment-induced by Ethanol Exposure in Adolescent Rat
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Kim YJ, Park JM, Song MK, Seong HH, Kim YJ
- KMID: 2361642
- J Korean Biol Nurs Sci.
- 2016 Nov;18(4):274-279.
- doi: 10.7586/jkbns.2016.18.4.274
PURPOSE: Adolescents who experienced the alcohol consumption have gradually increased. Adolescence is a critical period of the neural plasticity in the brain. Neural plasticity is mediated by neurotrophins and has... -
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- miR-34a Inhibitor May Effectively Protect against Sevoflurane-Induced Hippocampal Apoptosis through the Wnt/β-Catenin Pathway by Targeting Wnt1
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Zhao X, Sun Y, Ding Y, Zhang J, Li K
- KMID: 2426335
- Yonsei Med J.
- 2018 Dec;59(10):1205-1213.
- doi: 10.3349/ymj.2018.59.10.1205
PURPOSE: Research has shown that sevoflurane-induced toxicity causes neurodegeneration in the developing brain. miR-34a has been found to negatively regulate ketamine-induced hippocampal apoptosis and memory impairment. However, the role of... -
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- Theracurmin Ameliorates Cognitive Dysfunctions in 5XFAD Mice by Improving Synaptic Function and Mitigating Oxidative Stress
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Kim J, Kim J, Huang Z, Goo N, Bae HJ, Jeong Y, Park HJ, Cai M, Cho K, Jung SY, Bae SK, Ryu JH
- KMID: 2447860
- Biomol Ther.
- 2019 May;27(3):327-335.
- doi: 10.4062/biomolther.2019.046
As the elderly population is increasing, Alzheimer's disease (AD) has become a global issue and many clinical trials have been conducted to evaluate treatments for AD. As these clinical trials... -
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- Histopathological and Neurobehavioral Characterization in Adult Mice Exposed to Traumatic Brain Injury
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Oh KY, Choi DW, Jang MS, Lee JH, Kim SC, Park JS, Lee SW, Kim H
- KMID: 2394394
- J Korean Soc Emerg Med.
- 2017 Oct;28(5):457-466.
- doi: 10.0000/jksem.2017.28.5.457
PURPOSE: Traumatic brain injury (TBI) is a significant cause of morbidity and mortality worldwide. Severity of the initial insult is one of the most significant factors affecting outcome following TBI.... -
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