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C2 Superior Facetal Osteotomy: A Novel Technique in Complex Craniovertebral Junction Surgery for C1 Lateral Mass Screw Placement

Singh DK, Shankar D, Chand VK, Singh RK, Singh N

Complex craniovertebral junction (CVJ) defects account for a considerable proportion of CVJ diseases. Given the heavily assimilated C1, an unfavorable C1–C2 joint orientation, an overriding C2 superior facet, a low-hanging...
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A Review on Renal Toxicity Profile of Common Abusive Drugs

Singh VP, Singh N, Jaggi AS

Drug abuse has become a major social problem of the modern world and majority of these abusive drugs or their metabolites are excreted through the kidneys and, thus, the renal...
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Fracture of the insertion cannula during retrograde intubation: a rare complication

Mishra N, Singh N

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A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents

Randhawa P, Singh K, Singh N, Jaggi AS

Ulcerative colitis and Crohn's disease are a set of chronic, idiopathic, immunological and relapsing inflammatory disorders of the gastrointestinal tract referred to as inflammatory bowel disorder (IBD). Although the etiological...
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Ambiguous pediatric endotracheal tube intubation depth markings: a need for standardization

Singh N, Mohanty CR, Rao PB

No abstract available.
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Patients with celiac disease are at high risk of developing metabolic syndrome and fatty liver

Agarwal A, Singh A, Mehtab W, Gupta V, Chauhan A, Rajput MS, Singh N, Ahuja V, Makharia GK

Background/Aims: Gluten-free diet has an excess of fats and simple sugars and puts patients with celiac disease at risk of metabolic complications including metabolic syndrome and fatty liver. We assessed...
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Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection

Singh L, Kulshrestha R, Singh N, Jaggi AS

Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic...
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Advanced Glycation End Products and Diabetic Complications

Singh VP, Bali A, Singh N, Jaggi AS

During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation...
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Near-peer mentoring to complement faculty mentoring of first-year medical students in India

Singh S, Singh N, Dhaliwal U

PURPOSE: The first year is stressful for new medical students who have to cope with curricular challenges, relocation issues, and separation from family. Mentoring reduces stress and facilitates adaptation. A...
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Decline in Pulmonary Function Tests after Menopause

Memoalia J, Anjum B, Singh N, Gupta M

OBJECTIVES: Menopause is the permanent cessation of menstruation resulting from the loss of ovarian follicular activity. There is limited and conflicting evidence for an association between lung function and menopause....
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Central venous catheter malposition due to dialysis catheter: a case report

Rao PB, Singh N, Samson S

A 56-year-old man on maintenance hemodialysis was admitted to the intensive care unit with septic shock and coagulopathy. As there was a dialysis catheter in the right internal jugular vein,...
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Neurogenic pathways in remote ischemic preconditioning induced cardioprotection: Evidences and possible mechanisms

Aulakh AS, Randhawa P, Singh N, Jaggi AS

Remote ischemic preconditioning (RIPC) is an intrinsic phenomenon whereby 3~4 consecutive ischemia-reperfusion cycles to a remote tissue (noncardiac) increases the tolerance of the myocardium to sustained ischemiareperfusion induced injury. Remote...
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Prolyl 4 Hydroxylase: A Critical Target in the Pathophysiology of Diseases

Kant R, Bali A, Singh N, Jaggi AS

Prolyl 4 hydroxylases (P4H) are iron- and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical role in the regulating oxygen homeostasis in the local tissues as well...
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Sex and Gender Differences in Stroke and Their Practical Implications in Acute Care

Ospel J, Singh N, Ganesh A, Goyal M

There are several controversies regarding the role of sex and gender in the pathophysiology and management of acute stroke. Assessing the role of sex, i.e., biological/pathophysiological factors, and gender, i.e.,...
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Different Ways to Die: Cell Death Pathways and Their Association With Spinal Cord Injury

Guha L, Singh N, Kumar H

Cell death is a systematic/nonsystematic process of cessation of normal morphology and functional properties of the cell to replace and recycle old cells with new also promoting inflammation in some...
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Effect of Neurosteroid Modulation on Global Ischaemia-Reperfusion-Induced Cerebral Injury in Mice

Grewal AK, Jaggi AS, Rana AC, Singh N

The present study was designed to investigate the putative effect of neurosteroid modulation on global ischaemia-reperfusion-induced cerebral injury in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant...
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Effect of Closed Suction Drain on Blood Loss and Transfusion Rates in Simultaneous Bilateral Total Knee Arthroplasty: A Prospective Randomized Study

Jhurani A, Shetty GM, Gupta V, Saxena P, Singh N

PURPOSE: Simultaneous bilateral total knee arthroplasty (TKA) is associated with excessive blood loss and morbidity arising from postoperative reduction in hemoglobin (Hb). The purpose of this prospective randomized study was...
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Replacing Alteplase with Tenecteplase: Is the Time Ripe?

Singh N, Menon BK, Dmytriw AA, Regenhardt RW, Hirsch JA, Ganesh A

Thrombolysis for acute ischemic stroke has predominantly been with alteplase for over a quarter of a century. In recent years, with trials showing evidence of higher rates of successful reperfusion,...
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Hemodynamics of Leptomeningeal Collaterals after Large Vessel Occlusion and Blood Pressure Management with Endovascular Treatment

Kim BJ, Singh N, Menon BK

Endovascular therapy (EVT) is an effective treatment for ischemic stroke due to large vessel occlusion (LVO). Unlike intravenous thrombolysis, EVT enables visualization of the restoration of blood flow, also known...
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Effects of Erythropoietin on Memory Deficits and Brain Oxidative Stress in the Mouse Models of Dementia

Kumar R, Jaggi AS, Singh N

The present study was undertaken to explore the potential of erythropoietin in memory deficits of mice. Memory impairment was produced by scopolamine (0.5 mg/kg, i.p.) and intracerebroventricular streptozotocin (i.c.v STZ,...
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