- Host-Pathogen Interactions Operative during Mycobacteroides abscessus Infection
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Park EJ, Silwal P, Jo EK
- KMID: 2523801
- Immune Netw.
- 2021 Dec;21(6):e40.
- doi: 10.4110/in.2021.21.e40
Mycobacteroides abscessus (previously Mycobacteroides abscessus; Mabc), one of rapidly growing nontuberculous mycobacteria (NTM), is an important pathogen of NTM pulmonary diseases (NTM-PDs) in both immunocompetent and immunocompromised individuals. Mabc infection... -
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- Host-Pathogen Dialogues in Autophagy, Apoptosis, and Necrosis during Mycobacterial Infection
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Kim JK, Silwal P, Jo EK
- KMID: 2511858
- Immune Netw.
- 2020 Oct;20(5):e37.
- doi: 10.4110/in.2020.20.e37
Mycobacterium tuberculosis (Mtb) is an etiologic pathogen of human tuberculosis (TB), a serious infectious disease with high morbidity and mortality. In addition, the threat of drug resistance in anti-TB therapy... -
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- Tryptophan Negatively Regulates IgE-mediated Mast Cell Activation
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Silwal P, Shin K, Choi S, Namgung U, Lee CY, Heo JY, Lim K, Park JI, Kim KH, Park SK
- KMID: 2385297
- Korean J Phys Anthropol.
- 2017 Jun;30(2):53-60.
- doi: 10.11637/kjpa.2017.30.2.53
Mast cells are major immune cells in allergy to secrete allergic mediators by a degranulation process and make and secrete inflammatory lipids and cytokines in response to antigen stimulation. An... -
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- Vitamin D-Cathelicidin Axis: at the Crossroads between Protective Immunity and Pathological Inflammation during Infection
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Chung C, Silwal P, Kim I, Modlin RL, Jo EK
- KMID: 2500011
- Immune Netw.
- 2020 Apr;20(2):e12.
- doi: 10.4110/in.2020.20.e12
Vitamin D signaling plays an essential role in innate defense against intracellular microorganisms via the generation of the antimicrobial protein cathelicidin. In addition to directly binding to and killing a... -
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- Dexamethasone Induces FcgammaRIIb Expression in RBL-2H3 Cells
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Silwal P, Lee MN, Lee CJ, Hong JH, Namgung U, Lee ZW, Kim J, Lim K, Kweon GR, Park JI, Park SK
- KMID: 2285447
- Korean J Physiol Pharmacol.
- 2012 Dec;16(6):393-398.
- doi: 10.4196/kjpp.2012.16.6.393
Mast cells are involved in allergic responses, protection against pathogens and autoimmune diseases. Dexamethasone (Dex) and other glucocorticoids suppress FcepsilonRI-mediated release of inflammatory mediators from mast cells. The inhibition mechanisms... -
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- Adenine attenuates lipopolysaccharide-induced inflammatory reactions
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Silwal P, Lim K, Heo JY, Park JI, Namgung U, Park SK
- KMID: 2414262
- Korean J Physiol Pharmacol.
- 2018 Jul;22(4):379-389.
- doi: 10.4196/kjpp.2018.22.4.379
A nucleobase adenine is a fundamental component of nucleic acids and adenine nucleotides. Various biological roles of adenine have been discovered. It is not produced from degradation of adenine nucleotides... -
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- COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis
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Sohn KM, Lee SG, Kim HJ, Cheon S, Jeong H, Lee J, Kim IS, Silwal P, Kim YJ, Paik S, Chung C, Park C, Kim YS, Jo EK
- KMID: 2507100
- J Korean Med Sci.
- 2020 Sep;35(38):e343.
- doi: 10.3346/jkms.2020.35.e343
Background: Observational studies of the ongoing coronavirus disease 2019 (COVID-19) outbreak suggest that a ‘cytokine storm’ is involved in the pathogenesis of severe illness. However, the molecular mechanisms underlying the altered... -
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