- The Effect of Phosphodiesterase-4-Specific Inhibitor in the Rat Model of Spinal Nerve Ligation
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Kim SH, Park BN, Kim SW
- KMID: 1814115
- J Korean Neurosurg Soc.
- 2011 Aug;50(2):109-113.
- doi: 10.3340/jkns.2011.50.2.109
OBJECTIVE: Peripheral neuropathy is characterized by hyperalgesia, spontaneous burning pain, and allodynia. The purpose of this study was to investigate the effect of rolipram, a phosphodiesterase-4-specific inhibitor, in a segmental... -
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- Rolipram, a Phosphodiesterase 4 Inhibitor, Stimulates Inducible cAMP Early Repressor Expression in Osteoblasts
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Cho ES, Yu JH, Kim MS, Yim M
- KMID: 2158125
- Yonsei Med J.
- 2005 Feb;46(1):149-154.
- doi: 10.3349/ymj.2005.46.1.149
Phosphodiesterase (PDE) 4 inhibitors have been shown to induce the cAMP-mediated signaling pathway by inhibiting cAMP hydrolysis. This study investigated the effect of a PDE4 inhibitor on the expression of... -
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- The Effect of Phosphodiesterase Type 4 and 5 Inhibitors on Ileal Motor Function of the Guinea Pig
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Park HJ, Choi SW, Lee YH, Lim JH, Lee SI, Park IS
- KMID: 2085016
- Korean J Gastroenterol.
- 2002 May;39(5):343-349.
BACKGROUND/AIMS: Intracellular cAMP or cGMP is degraded by cyclic nucleotide phosphodiesterase (PDE). We hypothesized that PDE inhibitors modulate the peristalsis and nerve-induced responses of the smooth muscle of the guinea... -
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- The Modulation of IL-12 by Phosphodiesterase IV Inhibitor and Subsequent Changes of Th-1, Th-2 Cytokines in Human Endometrial Tissue
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Park WI, Kim EK, Ko DS, Hong SY, Na JY, Shin JH, Kim DW
- KMID: 2272121
- Korean J Obstet Gynecol.
- 2003 Aug;46(8):1500-1509.
OBJECTIVE: To assess the capability of phosphodiesterase type IV inhibitor (rolipram) to suppress IL-12 in human decidua and the subsequent changes of Th-2 cytokine (IL-10) and Th-1 cytokine (TNF-alpha). METHODS: Decidual... -
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- Protective Effect of Administered Rolipram against Radiation-Induced Testicular Injury in Mice
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Lee W, Son Y, Jang H, Bae MJ, Kim J, Kang D, Kim JS
- KMID: 2320736
- World J Mens Health.
- 2015 Apr;33(1):20-29.
- doi: 10.5534/wjmh.2015.33.1.20
PURPOSE: Pelvic irradiation for the treatment of cancer can affect normal cells, such as the rapidly proliferating spermatogenic cells of the testis, leading to infertility, a common post-irradiation problem. The... -
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- Electrophysiological and Behavioral Changes by Phosphodiesterase 4 Inhibitor in a Rat Model of Alcoholic Neuropathy
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Han KH, Kim SH, Jeong IC, Lee YH, Chang SJ, Park BN, Kim SW
- KMID: 2190520
- J Korean Neurosurg Soc.
- 2012 Jul;52(1):32-36.
- doi: 10.3340/jkns.2012.52.1.32
OBJECTIVE: Alcoholic neuropathy is characterized by allodynia (a discomfort evoked by normally innocuous stimuli), hyperalgesia (an exaggerated pain in response to painful stimuli) and spontaneous burning pain. The aim of... -
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- Penile Erection Induced by Scoparone from Artemisia capillaris through the Nitric Oxide-Cyclic Guanosine Monophosphate Signaling Pathway
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Choi BR, Kim HK, Park JK
- KMID: 2398569
- World J Mens Health.
- 2017 Dec;35(3):196-204.
- doi: 10.5534/wjmh.17023
PURPOSE: The objective of this study was to evaluate the relaxant effect of scoparone from Artemisia capillaris on rabbit penile corpus cavernosum smooth muscle (PCCSM) and to elucidate the mechanism... -
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- Relaxant and anti-inflammatory effect of two thalidomide analogs as PDE-4 inhibitors in pregnant rat uterus
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Muñoz-Pérez VM, Fernández-MartÃnez E, Ponce-Monter H, Ortiz MI
- KMID: 2384457
- Korean J Physiol Pharmacol.
- 2017 Jul;21(4):429-437.
- doi: 10.4196/kjpp.2017.21.4.429
The aim of this study was to evaluate the relaxant and anti-inflammatory effects of two thalidomide analogs as phosphodiesterase-4 (PDE-4) inhibitors in pregnant rat uterus. Uteri from Wistar female rats... -
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- Effects of Schisandra chinensis fruit extract and gomisin A on the contractility of penile corpus cavernosum smooth muscle: a potential mechanism through the nitric oxide - cyclic guanosine monophosphate pathway
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Choi BR, Kim HK, Park JK
- KMID: 2420994
- Nutr Res Pract.
- 2018 Aug;12(4):291-297.
- doi: 10.4162/nrp.2018.12.4.291
BACKGROUND/OBJECTIVES: This study evaluated the effects and molecular mechanisms of the Schisandra chinensis fruit extract (SC) and its major compound gomisin A (GA), on the contractility of rabbit penile corpus... -
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- Interaction of forskolin with the effect of N-6-cyclopentyladenosine on norepinephrine release in rat hippocampus
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Choi BK, Kim DK, Son Y, Yang UJ
- KMID: 2285166
- Korean J Physiol Pharmacol.
- 1997 Jun;1(3):225-231.
As it has been reported that the depolarization-induced norepinephrine (NE) release is modulated by activation of presynaptic A-1-adenosine heteroreceptor and various lines of evidence indicate the involvement of adenylate cyclase system in A-1-adenosine... -
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