- Expression of TRAIL Receptors in Cervical Cancer
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Chang SJ, Ryu HS, Kim MS, Joo HJ, Chang KH, Oh KS
- KMID: 2083747
- Korean J Gynecol Oncol Colposc.
- 2000 Mar;11(1):45-54.
Apoptosis is an intrinsic and fundamental biological process that plays a critical role in the normal development of multicellular organisms and in maintaining tissue homeostasis. Some of the well known... -
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- Expression of TRAIL (Apo-2L)/TRAIL Receptor System Related to Apoptosis at the Human Extraembryonic Tissues and Gestational Trophoblastic Disease
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Chung IB, Cha DS, Sohn JH, Choi SJ, Han KH
- KMID: 2272186
- Korean J Obstet Gynecol.
- 2003 Nov;46(11):2156-2161.
Human uterus has been known as a immune privileged site for the product of conception. At the feto-maternal interface, Fas system is a underlying main mechanism of maternal immune acceptance.... -
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- Isoproterenol Enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis in Human Embryonic Kidney Cells through Death Receptor 5 up-Regulation
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Eom YW, Jung HY, Oh JE, Lee JW, Ahn MS, Youn YJ, Ahn SG, Kim JY, Lee SH, Yoon J, Yoo BS
- KMID: 2223774
- Korean Circ J.
- 2016 Jan;46(1):93-98.
- doi: 10.4070/kcj.2016.46.1.93
BACKGROUND AND OBJECTIVES: Chronic impairment of beta-adrenergic receptor signaling increases cardiac apoptosis, hypertrophy and fibrosis. The aim of this study was to investigate whether isoproterenol (ISO), an agonist of the... -
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- Apoptosis and upregulation of TNF-alpha and TRAIL receptor 1 (DR4) in the pathogenesis of food protein-induced enterocolitis syndrome
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Hwang JB, Kim SP, Kang YN, Lee SR, Suh SI, Kwon TK
- KMID: 2073578
- Korean J Pediatr.
- 2010 Apr;53(4):525-531.
- doi: 10.3345/kjp.2010.53.4.525
PURPOSE: Expression levels of tumor necrosis factor (TNF)-alpha expression on the mucosa of the small intestine is increased in patients with villous atrophy in food protein-induced enterocolitis syndrome (FPIES). TNF-alpha... -
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- Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation
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Moon MH, Jeong JK, Seo JS, Seol JW, Lee YJ, Xue M, Jackson CJ, Park SY
- KMID: 1109402
- Exp Mol Med.
- 2011 Mar;43(3):138-145.
- doi: 10.3858/emm.2011.43.3.016
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily of cytokines, is one of the most promising candidates for cancer therapeutics. However, many osteosarcomas are resistant... -
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- Up-regulation of the DR5 Expression by Proteasome Inhibitor MG132 Augments TRAIL-Induced Apoptosis in Soft Tissue Sarcoma Cell Lines
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Cheong HJ, Lee KS, Woo IS, Won JH, Byun JH
- KMID: 2167538
- Cancer Res Treat.
- 2011 Jun;43(2):124-130.
PURPOSE: Current chemotherapeutics for treating locally advanced or metastatic soft tissue sarcomas (STS) are limited. Accordingly, the present in vitro study was conducted to evaluate the effects of treatment of... -
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- The Synergistic Apoptotic Interaction of Indole-3-Carbinol and Genistein with TRAIL on Endometrial Cancer Cells
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Parajuli B, Shin SJ, Kwon SH, Cha SD, Lee HG, Bae I, Cho CH
- KMID: 1786959
- J Korean Med Sci.
- 2013 Apr;28(4):527-533.
- doi: 10.3346/jkms.2013.28.4.527
Induction of apoptosis in target cells is a key mechanism by which chemotherapy promotes cell killing. The purpose of this study was to determine whether Indole-3-Carbinol (I3C) and Genistein in... -
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- Cytotoxic Effects of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)and its Molecular Mechanism in Human Gastric Cancer Cells
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Kim JH, Nam SY, Lee BL
- KMID: 2092891
- Korean J Anat.
- 2007 Mar;40(1):69-76.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)induces apoptosis in some cancer cells such as breast,prostate,lung,and colon cancer cells,but not normal cells.However,because the effects of TRAIL in gastric cancer cells is unclear,we... -
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- Selective expression of death receptor 4 and induction of apoptosis by HPV E6
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Choi E, Koh H, Shin S, Kim K
- KMID: 2244946
- Korean J Gynecol Oncol Colposc.
- 2002 Jun;13(2):139-145.
Human papillomaviruses, especially type 16 and 18, have been known to be closely associated with human cervix cancer. The E6 and E7 proteins encoded by these viruses disrupt normal cell... -
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- Paxilline enhances TRAIL-mediated apoptosis of glioma cells via modulation of c-FLIP, survivin and DR5
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Kang YJ, Kim IY, Kim EH, Yoon MJ, Kim SU, Kwon TK, Choi KS
- KMID: 991620
- Exp Mol Med.
- 2011 Jan;43(1):24-34.
- doi: 10.3858/emm.2011.43.1.003
Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) induces apoptosis selectively in cancer cells while sparing normal cells. However, many cancer cells are resistant to TRAIL-induced cell death. Here, we report that... -
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- Restoration of the TRAIL Resistance with a Low Dose Doxorubicin in Acute Leukemia Cell Lines
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Cheong HJ, Kim SJ, Kim HJ, Kim SH, Byun JH, Lee NS, Kim CK, Lee KT, Park SK, Won JH, Hong DS, Park HS
- KMID: 2014033
- Korean J Hematol.
- 2003 May;38(2):108-118.
BACKGROUND: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been reported to induce apoptosis in various tumor cells but not in normal cells, which suggests its potential use as a tumor-specific... -
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- Differential Expressions of Apoptosis-related Genes in Lung Cancer Cell Lines Determine the Responsiveness to Ionizing Radiation
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Lee SY, Choi MK, Lim JM, Wu HG, Kim JH, Park WY
- KMID: 2166320
- Genomics Inform.
- 2008 Mar;6(1):36-43.
Radiotherapy would be the choice of treatment for human cancers, because of high cost-effectiveness. However, a certain population of patients shows a resistance to radiotherapy and recurrence. In an effort... -
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- Down-Regulation of Survivin by Nemadipine-A Sensitizes Cancer Cells to TRAIL-Induced Apoptosis
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Park SH, Park SJ, Kim JO, Shin JH, Kim ES, Jo YK, Kim JS, Park SJ, Jin DH, Hwang JJ, Lee SJ, Jeong SY, Lee C, Kim I, Cho DH
- KMID: 2170682
- Biomol Ther.
- 2013 Jan;21(1):29-34.
The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor family of cytokines. TRAIL selectively induces apoptotic cell death in various tumors and cancer... -
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- Ursodeoxycholic Acid Induces Death Receptor-mediated Apoptosis in Prostate Cancer Cells
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Lee WS, Jung JH, Panchanathan R, Yun JW, Kim DH, Kim HJ, Kim GS, Ryu CH, Shin SC, Hong SC, Choi YH, Jung JM
- KMID: 2375544
- J Cancer Prev.
- 2017 Mar;22(1):16-21.
- doi: 10.15430/JCP.2017.22.1.16
BACKGROUND: Bile acids have anti-cancer properties in a certain types of cancers. We determined anticancer activity and its underlying molecular mechanism of ursodeoxycholic acid (UDCA) in human DU145 prostate cancer... -
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- Induction of apoptosis by a hexane extract of aged black garlic in the human leukemic U937 cells
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Park C, Park S, Chung YH, Kim GY, Choi YW, Kim BW, Choi YH
- KMID: 2313720
- Nutr Res Pract.
- 2014 Apr;8(2):132-137.
BACKGROUND/OBJECTIVES: In this study, the apoptogenic activity and mechanisms of cell death induced by hexane extract of aged black garlic (HEABG) were investigated in human leukemic U937 cells. MATERIALS/METHODS: Cytotoxicity was... -
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