- Stimulatory Effect of beta-glucans on Immune Cells
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Kim HS, Hong JT, Kim Y, Han SB
- KMID: 1449809
- Immune Netw.
- 2011 Aug;11(4):191-195.
- doi: 10.4110/in.2011.11.4.191
beta-Glucans are naturally occurring polysaccharides that are produced by bacteria, yeast, fungi, and many plants. Although their pharmacological activities, such as immunomodulatory, anti-infective and anti-cancer effects, have been well studied,... -
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- Role of Prostaglandin D2 in the Pathogenesis of Asthma
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- KMID: 2299463
- Korean J Asthma Allergy Clin Immunol.
- 2012 Sep;32(3):144-149.
Prostaglandin D2 is a major lipid mediator released from activated mast cells of which metabolite 9alpha,11beta-prostaglandin F2 are used as a biomarker of mast cell activation in various type of... -
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- Natural Killer Cell and Cancer Immunotherapy
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Kim HS
- KMID: 2168222
- Hanyang Med Rev.
- 2013 Feb;33(1):59-64.
- doi: 10.7599/hmr.2013.33.1.59
Cancer remains the leading cause of death worldwide despite intense efforts in developing innovative treatments. Current approaches in cancer therapy are mainly directed to a selective targeting of cancer cells... -
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- Meta-Analysis of Genetic Association Studies
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Lee YH
- KMID: 2363199
- Ann Lab Med.
- 2015 May;35(3):283-287.
- doi: 10.3343/alm.2015.35.3.283
The object of this review is to help readers to understand meta-analysis of genetic association study. Genetic association studies are a powerful approach to identify susceptibility genes for common diseases.... -
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- Prostaglandin D2 and TH2 Inflammation in the Pathogenesis of Bronchial Asthma
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Arima M, Fukuda T
- KMID: 1036144
- Korean J Intern Med.
- 2011 Mar;26(1):8-18.
- doi: 10.3904/kjim.2011.26.1.8
Prostaglandin D2 (PGD2) is a major prostanoid, produced mainly by mast cells, in allergic diseases, including bronchial asthma. PGD2-induced vasodilatation and increased permeability are well-known classical effects that may be... -
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- Phenotypic and Functional Analysis of HL-60 Cells Used in Opsonophagocytic-Killing Assay for Streptococcus pneumoniae
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Kim KH, Seoh JY, Cho SJ
- KMID: 2129643
- J Korean Med Sci.
- 2015 Feb;30(2):145-150.
- doi: 10.3346/jkms.2015.30.2.145
Differentiated HL-60 is an effector cell widely used for the opsonophagocytic-killing assay (OPKA) to measure efficacy of pneumococcal vaccines. We investigated the correlation between phenotypic expression of immunoreceptors and phagocytic... -
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- Characterization of Binding and Phagocytosis of Oxidatively Damaged Erythrocyte to Macrophage
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Ko HS, Kim IS, Lee KJ, Kim SW, Kim CJ, Ryu WS
- KMID: 759614
- Korean J Intern Med.
- 2002 Dec;17(4):220-226.
BACKGROUND: Scavenger receptors are thought to be involved in the recognition of oxidized low-density lipoprotein (oxLDL) and oxidized erythrocyte (oxRBC). However, there are controversies about the kind of receptors... -
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- Potentiation of Innate Immunity by beta-Glucans
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Seong SK, Kim HW
- KMID: 2312582
- Mycobiology.
- 2010 Jun;38(2):144-148.
beta-Glucans have been known to exhibit antitumor activities by potentiating host immunity by an unknown mechanism. The C-type lectin dectin-1, a beta-glucan receptor, is found on the macrophage and can... -
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- Current Understanding of HMGB1-mediated Autophagy
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Kwak MS, Shin JS
- KMID: 2168685
- J Bacteriol Virol.
- 2013 Jun;43(2):148-154.
- doi: 10.4167/jbv.2013.43.2.148
Reactive oxygen species (ROS) is an oxidative stress to which cells respond by activating various defense mechanisms or cell death. Autophagy associated with oxidative stress response is a process to... -
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- Increase of NKG2D ligands and sensitivity to NK cell-mediated cytotoxicity of tumor cells by heat shock and ionizing radiation
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Kim JY, Son YO, Park SW, Bae JH, Chung JS, Kim HH, Chung BS, Kim SH, Kang CD
- KMID: 1098081
- Exp Mol Med.
- 2006 Oct;38(5):474-484.
In this study, we have investigated if current cancer therapeutic modalities including hyperthermia and ionizing radiation can increase the expression of NKG2D ligands in human cancer cell lines. The expressions... -
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- Correlation between Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Endoscopic Activity in Intestinal Behcet's Disease
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Lee HJ, Shin HS, Jang HW, Kim SW, Park SJ, Hong SP, Kim TI, Kim WH, Cheon JH
- KMID: 2130820
- Yonsei Med J.
- 2014 Jul;55(4):960-966.
- doi: 10.3349/ymj.2014.55.4.960
PURPOSE: The serum levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) have recently been shown to be correlated highly with disease activity in patients with intestinal Behcet's disease... -
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- Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer's disease
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Choi BR, Cho WH, Kim J, Lee HJ, Chung C, Jeon WK, Han JS
- KMID: 2155340
- Exp Mol Med.
- 2014 Feb;46(2):e75.
- doi: 10.1038/emm.2013.147
The receptor for advanced glycation end products (RAGE) has been reported to have a pivotal role in the pathogenesis of Alzheimer's disease (AD). This study investigated RAGE levels in the... -
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- Genetic screening in young women diagnosed with endometrial cancer
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Pecorino B, Rubino C, Guardalà FVF, Galia A, Scollo P
- KMID: 2413851
- J Gynecol Oncol.
- 2017 Jan;28(1):e4.
- doi: 10.3802/jgo.2017.28.e4
OBJECTIVE: To evaluate the importance of Lynch syndrome associated risk screening in the patients aged less than 50 years affected from endometrial cancer. METHODS: From 2007 to 2014, 41 patients affected... -
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- Topology of Scavenger Receptor Class B Type I (SR-BI) on Brush Border Membrane
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Han CH, Lee MH
- KMID: 1097342
- J Vet Sci.
- 2002 Dec;3(4):265-272.
Both hydropathy plot and in vitro translation results predict the topology of SR-BI; the receptor is an integral membrane protein of 509 amino acids, consisting of a short cytoplasmic N-terminus... -
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- Microglial P2X7 receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease
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Lee HG, Won SM, Gwag BJ, Lee YB
- KMID: 991618
- Exp Mol Med.
- 2011 Jan;43(1):7-14.
- doi: 10.3858/emm.2011.43.1.001
The possibility that P2X7 receptor (P2X7R) expression in microglia would mediate neuronal damage via reactive oxygen species (ROS) production was examined in the APPswe/PS1dE9 mouse model of Alzheimer's disease (AD).... -
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- Inhibitory effect of receptor for advanced glycation end products (RAGE) on the TGF-beta-induced alveolar epithelial to mesenchymal transition
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Song JS, Kang CM, Park CK, Yoon HK, Lee SY, Ahn JH, Moon HS
- KMID: 1022128
- Exp Mol Med.
- 2011 Sep;43(9):517-524.
- doi: 10.3858/emm.2011.43.9.059
Idiopathic pulmonary fibrosis (IPF) is a lethal parenchymal lung disease characterized by myofibroblast proliferation. Alveolar epithelial cells (AECs) are thought to produce myofibroblasts through the epithelial to mesenchymal transition (EMT).... -
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- X-linked Severe Combined Immunodeficiency Syndrome: The First Korean Case with gamma c Chain Gene Mutation and Subsequent Genetic Counseling
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Jo EK, Kumaki S, Wei D, Tsuchiya S, Kanegane H, Song CH, Noh HY, Kim YO, Kim SY, Chung HY, Kim YH, Kook H
- KMID: 1785705
- J Korean Med Sci.
- 2004 Feb;19(1):123-126.
- doi: 10.3346/jkms.2004.19.1.123
X-linked severe combined immunodeficiency (X-SCID) is a rare, life-threatening immune disorder, caused by mutations in the gamma c chain gene, which encodes an essential component of the cytokine receptors for... -
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- Modulation of the Surface Expression of CD158 Killer Cell Ig-like Receptor by Interleukin-2 and Transforming Growth Factor-beta
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Shin EC, Choi KS, Kim SJ, Shin JS
- KMID: 1734134
- Yonsei Med J.
- 2004 Jun;45(3):510-514.
- doi: 10.3349/ymj.2004.45.3.510
Killer cell Ig-like receptor (KIR) binds to HLA class I molecules on the surface of target cells, and it confers inhibitory signals to NK cells. Although NK cytotoxicity can be... -
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- Pathobiological role of advanced glycation endproducts via mitogen-activated protein kinase dependent pathway in the diabetic vasculopathy
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Yoon YW, Kang TS, Lee BK, Chang W, Hwang KC, Rhee JH, Min PK, Hong BK, Rim SJ, Kwon HM
- KMID: 1094119
- Exp Mol Med.
- 2008 Aug;40(4):398-406.
- doi: 10.3858/emm.2008.40.4.398
Advanced glycation endproducts (AGEs) have been reported to play a role in neointimal formation and increase the rate of in-stent restenosis (ISR) in the diabetic coronary artery disease patients treated... -
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