- Pancreatic alpha-Cell Dysfunction in Type 2 Diabetes: Old Kids on the Block
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Moon JS, Won KC
- KMID: 2280650
- Diabetes Metab J.
- 2015 Feb;39(1):1-9.
- doi: 10.4093/dmj.2015.39.1.1
Type 2 diabetes (T2D) has been known as 'bi-hormonal disorder' since decades ago, the role of glucagon from alpha-cell has languished whereas beta-cell taking center stage. Recently, numerous findings indicate... -
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- GLP-1 Receptor Agonist and Non-Alcoholic Fatty Liver Disease
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Lee J, Hong SW, Rhee EJ, Lee WY
- KMID: 2174417
- Diabetes Metab J.
- 2012 Aug;36(4):262-267.
- doi: 10.4093/dmj.2012.36.4.262
Non-alcoholic fatty liver disease (NAFLD), one of the most common liver diseases, is caused by the disruption of hepatic lipid homeostasis. It is associated with insulin resistance as seen in... -
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- New Therapeutics for Diabetes Using Incretin Hormone
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Oh S
- KMID: 2259281
- Korean J Med.
- 2011 Jun;80(6):625-634.
New therapeutics for type 2 diabetes using incretin hormone were introduced recently. Incretin-based therapies consist of two types: GLP-1 agonists mainly acting on the GLP-1 receptor and dipeptidyl peptidase 4... -
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- Protective Effects of Glucagon Like Peptide-1 on HIT-T15 beta Cell Apoptosis via ER Stress Induced by 2-deoxy-D-glucose
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Kim JY, Lee SK, Baik HW, Lee KH, Kim HJ, Park KS, Kim BJ
- KMID: 2222455
- Korean Diabetes J.
- 2008 Dec;32(6):477-487.
- doi: 10.4093/kdj.2008.32.6.477
BACKGROUND: The characteristic feature of pancreatic beta cells is highly developed endoplasmic reticulum (ER) due to a heavy engagement in insulin secretion. The ER serves several important function, including post-translational... -
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- Effect of the combination of metformin and fenofibrate on glucose homeostasis in diabetic Goto-Kakizaki rats
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Oh TJ, Shin JY, Kang GH, Park KS, Cho YM
- KMID: 2154249
- Exp Mol Med.
- 2013 Jul;45(7):e30.
Metformin has been reported to increase the expression of the glucagon-like peptide-1 (GLP-1) receptor in pancreatic beta cells in a peroxisome proliferator-activated receptor (PPAR)-alpha-dependent manner. We investigated whether a PPARalpha... -
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- Beta Cells Preservation in Diabetes using GLP-1 and Its Analog
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Kim BJ
- KMID: 2168165
- Hanyang Med Rev.
- 2009 May;29(2):140-147.
Diabetes Mellitus is a metabolic disease caused by impaired insulin secretion of pancreatic beta cells and increased insulin resistance of peripheral tissues. In Asian T2DM, progressive loss of beta cells... -
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- The Effects of Exendin-4 on IRS-2 Expression and Phosphorylation in INS-1 Cells
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Kim JH, Kim JW, Jeon SY, Park HS, Ham DS, You YH, Lee SH, Cho JH, Kang MJ, Lee KW, Kwon HS, Yoon KH, Cha BY, Lee KW, Kang SK, Son HY
- KMID: 2222506
- Korean Diabetes J.
- 2008 Apr;32(2):102-111.
- doi: 10.4093/kdj.2008.32.2.102
BACKGROUND: Insulin receptor substrate 2 (IRS-2) is a key regulator of beta cell proliferation and apoptosis. This study was aimed to investigate effect of the glucolipotoxicity on apoptosis in INS-1... -
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- Exendin-4 Protects Oxidative Stress-Induced beta-Cell Apoptosis through Reduced JNK and GSK3beta Activity
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Kim JY, Lim DM, Moon CI, Jo KJ, Lee SK, Baik HW, Lee KH, Lee KW, Park KY, Kim BJ
- KMID: 1779233
- J Korean Med Sci.
- 2010 Nov;25(11):1626-1632.
- doi: 10.3346/jkms.2010.25.11.1626
Oxidative stress induced by chronic hyperglycemia in type 2 diabetes plays a crucial role in progressive loss of beta-cell mass through beta-cell apoptosis. Glucagon like peptide-1 (GLP-1) has effects on... -
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- Microarray Analysis of Thyroid Stimulating Hormone, Insulin-Like Growth Factor-1, and Insulin-Induced Gene Expression in FRTL-5 Thyroid Cells
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Lee YJ, Park DJ, Shin CS, Park KS, Kim SY, Lee HK, Park YJ, Cho BY
- KMID: 1713298
- J Korean Med Sci.
- 2007 Oct;22(5):883-890.
- doi: 10.3346/jkms.2007.22.5.883
To determine which genes are regulated by thyroid stimulating hormone (thyrotropin, TSH), insulin and insulin-like growth factor-1 (IGF-1) in the rat thyroid, we used the microarray technology and observed the... -
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