- Molecular Vibration-Activity Relationship in the Agonism of Adenosine Receptors
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Chee HK, Oh SJ
- KMID: 2166514
- Genomics Inform.
- 2013 Dec;11(4):282-288.
- doi: 10.5808/GI.2013.11.4.282
The molecular vibration-activity relationship in the receptor-ligand interaction of adenosine receptors was investigated by structure similarity, molecular vibration, and hierarchical clustering in a dataset of 46 ligands of adenosine receptors.... -
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- Prostaglandin E2 Receptors on Upper Respiratory Tract
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Kim JK
- KMID: 2074132
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2009 Jul;52(7):553-559.
- doi: 10.3342/kjorl-hns.2009.52.7.553
Prostaglandin (PG) E2 exerts its actions by acting on a group of G-protein-coupled receptors (GPCRs). GPCRs responding to PGE2 consist of four subtypes namely E-prostanoid 1 (EP1), E-prostanoid 2 (EP2),... -
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- Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets
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Ferrell JM, Chiang JY
- KMID: 2454055
- Diabetes Metab J.
- 2019 Jun;43(3):257-272.
- doi: 10.4093/dmj.2019.0043
Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are... -
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- Intercellular Lipid Mediators and GPCR Drug Discovery
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Im DS
- KMID: 2170658
- Biomol Ther.
- 2013 Nov;21(6):411-422.
G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets.... -
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- Pleiotropic Effects of an Incretin Hormone
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Oh S
- KMID: 2173919
- J Korean Diabetes.
- 2013 Sep;14(3):120-124.
- doi: 10.4093/jkd.2013.14.3.120
The incretin hormones glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have recently received much attention for their roles in type 2 diabetes therapy. GLP-1 stimulated insulin secretion in... -
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- Signal Transduction of MUC5AC Expression in Airway Mucus Hypersecretory Disease
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Shim JJ
- KMID: 1970542
- Tuberc Respir Dis.
- 2003 Jul;55(1):21-30.
- doi: 10.4046/trd.2003.55.1.21
BACKGROUND: Mucin synthesis in airways has been reported to be regulated by the epidermal growth factor receptor (EGFR) system. Epidermal growth factor receptor transactivation was identified as a critical element... -
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- Multi-facets of Corticotropin-releasing Factor in Modulating Inflammation and Angiogenesis
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Im E
- KMID: 2381229
- J Neurogastroenterol Motil.
- 2015 Jan;21(1):25-32.
- doi: 10.5056/jnm14076
The family of corticotropin-releasing factor (CRF) composed of 4 ligands including CRF, urocortin (Ucn) 1, Ucn2, and Ucn3 is expressed both in the central nervous system and the periphery including... -
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- Mechanisms of Platelet Activation and Integrin alphaIIbeta3
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Joo SJ
- KMID: 2028756
- Korean Circ J.
- 2012 May;42(5):295-301.
- doi: 10.4070/kcj.2012.42.5.295
Platelet aggregation is not only an essential part of hemostasis, but also initiates acute coronary syndrome or ischemic stroke. The precise understanding of the activation mechanism of platelet aggregation is... -
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- Presynaptic Mechanism Underlying Regulation of Transmitter Release by G Protein Coupled Receptors
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Takahashi , Kajikawa Y, Kimura M, Saitoh N, Tsujimoto
- KMID: 1611227
- Korean J Physiol Pharmacol.
- 2004 Apr;8(2):69-76.
A variety of G protein coupled receptors (GPCRs) are expressed in the presynaptic terminals of central and peripheral synapses and play regulatory roles in transmitter release. The patch-clamp whole-cell recording... -
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- Somatostatin Receptors in Lung Cancer: From Function to Molecular Imaging and Therapeutics
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Callison J, Walker RC, Massion PP
- KMID: 2005737
- J Lung Cancer.
- 2011 Dec;10(2):69-76.
- doi: 10.6058/jlc.2011.10.2.69
Lung cancer is a deadly disease that is difficult to diagnose and even more difficult to treat effectively. Many pathways are known to affect tumor growth, and targeting these pathways... -
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- Leukotriene B(4) receptor 2 gene polymorphism (rs1950504, Asp196Gly) leads to enhanced cell motility under low-dose ligand stimulation
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Jang JH, Wei JD, Kim M, Kim JY, Cho AE, Kim JH
- KMID: 2396807
- Exp Mol Med.
- 2017 Nov;49(11):e402.
- doi: 10.1038/emm.2017.192
Recently, single-nucleotide polymorphisms (SNPs) in G-protein-coupled receptors (GPCRs) have been suggested to contribute to physiopathology and therapeutic effects. Leukotriene B4 receptor 2 (BLT2), a member of the GPCR family, plays... -
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- Functional Expression of P2Y Receptors in WERI-Rb1 Retinoblastoma Cells
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Kim NH, Park KS, Sohn JH, Yeh BI, Ko CM, Kong ID
- KMID: 2389110
- Korean J Physiol Pharmacol.
- 2011 Feb;15(1):61-66.
P2Y receptors are metabotropic G-protein-coupled receptors, which are involved in many important biologic functions in the central nervous system including retina. Subtypes of P2Y receptors in retinal tissue vary according... -
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- Anesthetic-induced myocardial protection in cardiac surgery: relevant mechanisms and clinical translation
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Soh S, Song JW, Choi N, Shim JK
- KMID: 2436048
- Anesth Pain Med.
- 2018 Jan;13(1):1-9.
- doi: 10.17085/apm.2018.13.1.1
Cardiac surgery is still associated with complications such as adverse perioperative cardiovascular events. Over the past two decades, many studies have shown that volatile anesthetics and opioids provide myocardial protection... -
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- Native Low-Density Lipoprotein-Dependent Interleukin-8 Production Through Pertussis Toxin-Sensitive G-Protein Coupled Receptors and Hydrogen Peroxide Generation Contributes to Migration of Human Aortic Smooth Muscle Cells
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Lim HK, Ryoo S
- KMID: 1777012
- Yonsei Med J.
- 2011 May;52(3):413-419.
- doi: 10.3349/ymj.2011.52.3.413
PURPOSE: Stimulation of human aortic smooth muscle cells (hAoSMCs) with native low-density lipoprotein (nLDL) induced the production of interleukin-8 (IL-8) that is involved in the pathogenesis of cardiovascular diseases. However,... -
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- Synergistic induction of cancer cell migration regulated by Gbetagamma and phosphatidylinositol 3-kinase
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Kim EK, Yun SJ, Ha JM, Kim YW, Jin IH, Woo DH, Lee HS, Ha HK, Bae SS
- KMID: 1387359
- Exp Mol Med.
- 2012 Aug;44(8):483-491.
Phosphatidylinositol 3-kinase (PI3K) is essential for both G protein-coupled receptor (GPCR)- and receptor tyrosine kinase (RTK)-mediated cancer cell migration. Here, we have shown that maximum migration is achieved by full... -
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- Relaxin Receptor RXFP1 and RXFP2 Expression in Ligament, Tendon, and Shoulder Joint Capsule of Rats
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Kim JH, Lee SK, Lee SK, Kim JH, Fredericson M
- KMID: 2373710
- J Korean Med Sci.
- 2016 Jun;31(6):983-988.
- doi: 10.3346/jkms.2016.31.6.983
Numerous musculoskeletal disorders are caused by thickened ligament, tendon stiffness, or fibrosis of joint capsule. Relaxin, a peptide hormone, can exert collagenolytic effect on ligamentous and fibrotic tissues. We hypothesized... -
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- Expression of Bitter Taste Receptors in Human Nasal Respiratory Epithelium
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An JM, Wu HW, Kim HJ, Kim CH, Moon SJ
- KMID: 2170774
- Int J Oral Biol.
- 2012 Jun;37(2):57-62.
The nasal cavity encounters various irritants during inhalation such as dust and pathogens. To detect and remove these irritants, it has been postulated that the nasal mucosa epithelium has a... -
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- The Effects of Hantaan Virus on the Expression of Platelet Activating Factor Receptor and on the Activity of Platelet Activating Factor Acetylhydrolase
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Hwang JY, Park JW, Hong SY, Park HS
- KMID: 2320115
- Yeungnam Univ J Med.
- 2008 Jun;25(1):41-49.
BACKGROUND: The central physiological derangement of hemorrhagic fever with renal syndrome (HFRS) caused by hantaan virus (HTNV) is a vascular dysfunction, manifested by hemorrhage, impaired vascular tone and increased vascular... -
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- Intragastric gavage with denatonium benzoate acutely induces neuronal activation in the solitary tract nucleus via the vagal afferent pathway
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Jung HY, Kim W, Yoo DY, Nam SM, Kim JW, Choi JH, Yoon YS, Kim HY, Hwang IK
- KMID: 2070231
- J Vet Sci.
- 2014 Dec;15(4):459-464.
- doi: 10.4142/jvs.2014.15.4.459
Natural toxic substances have a bitter taste and their ingestion sends signals to the brain leading to aversive oral sensations. In the present study, we investigated chronological changes in c-Fos... -
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- Transcriptional profiling and Wnt signaling activation in proliferation of human hepatic stellate cells induced by PDGF-BB
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Shin H, Park SY, Lee KB, Shin E, Nam SW, Lee JY, Jang JJ
- KMID: 1384056
- Korean J Hepatol.
- 2009 Dec;15(4):486-495.
- doi: 10.3350/kjhep.2009.15.4.486
BACKGROUND/AIMS: This study aimed to better understand gene expression profiles of human hepatic stellate cell (HSC) activation and the relationship with the Wnt signaling pathway. METHODS: The global transcript levels... -
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