J Korean Diabetes.  2013 Sep;14(3):120-124. 10.4093/jkd.2013.14.3.120.

Pleiotropic Effects of an Incretin Hormone

• Oh S

• KMID: 2173919
• DOI: http://doi.org/10.4093/jkd.2013.14.3.120

Abstract

The incretin hormones glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have recently received much attention for their roles in type 2 diabetes therapy. GLP-1 stimulated insulin secretion in a glucose-dependent manner and is secreted by intestinal L cells. It also regulates blood glucose concentration, stomach motility, appetite, and body weight. These actions are mediated through G-protein-coupled receptors highly expressed on pancreatic beta cells and also exert indirect metabolic actions. Activation of GLP-1 receptors also produces nonglycemic effects in various tissues. The pleiotropic effects of GLP-1 have been recently reported. The mechanisms identified in preclinical studies have potential translational relevance for the treatment of disease. Here, the nonglycemic effects of GLP-1, especially those on the liver, central nervous system, and bone, were reviewed.

Keyword

Glucagon-like peptide 1; Incretins; Incretin/therapeutic use

MeSH Terms

Appetite
Blood Glucose
Body Weight
Central Nervous System
Enteroendocrine Cells
Glucagon
Glucagon-Like Peptide 1
Incretins
Insulin
Insulin-Secreting Cells
Liver
Receptors, G-Protein-Coupled
Stomach
Blood Glucose
Glucagon
Glucagon-Like Peptide 1
Incretins
Insulin
Receptors, G-Protein-Coupled

Reference

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