- Recent Update of Molecular Targeted Therapy in Pancreatic Cancer
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Cho JH
- KMID: 1501637
- Korean J Gastroenterol.
- 2013 Mar;61(3):147-154.
- doi: 10.4166/kjg.2013.61.3.147
Pancreatic ductal adenocarcinoma is one of the most dreaded malignancies and the 5th leading cause of cancer-related death in Korea. Late diagnosis and unfavorable response to both chemotherapy and radiotherapy... -
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- Perspectives of the Stomach Cancer Treatment: The Introduction of Molecular Targeted Therapy and the Hope for Cure
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Cheung DY, Kim JK
- KMID: 1501634
- Korean J Gastroenterol.
- 2013 Mar;61(3):117-127.
- doi: 10.4166/kjg.2013.61.3.117
The overall survival of patients with gastric cancer has increased markedly in Korea, even higher than those of developed nations in Western world. It is due to the virtue of... -
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- Modifiers of TGF-beta1 effector function as novel therapeutic targets of pulmonary fibrosis
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Lee CM, Park JW, Cho WK, Zhou Y, Han B, Yoon PO, Chae J, Elias JA, Lee CG
- KMID: 1792051
- Korean J Intern Med.
- 2014 May;29(3):281-290.
- doi: 10.3904/kjim.2014.29.3.281
Pulmonary fibrosis is a fatal progressive disease with no effective therapy. Transforming growth factor (TGF)-beta1 has long been regarded as a central mediator of tissue fibrosis that involves multiple organs... -
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- Molecular targeted therapy for advanced gastric cancer
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Kim JG
- KMID: 1501767
- Korean J Intern Med.
- 2013 Mar;28(2):149-155.
- doi: 10.3904/kjim.2013.28.2.149
Although medical treatment has been shown to improve quality of life and prolong survival, no significant progress has been made in the treatment of advanced gastric cancer (AGC) within the... -
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- A Perspective: Role of Targeted Therapy in Colon Cancer
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Chung HH, Jang BI
- KMID: 1501635
- Korean J Gastroenterol.
- 2013 Mar;61(3):128-135.
- doi: 10.4166/kjg.2013.61.3.128
Colorectal cancer is the third most common malignant disease in incidence according to a report in 2009 from Korea. The 5-fluorouracil (5-FU) remains to be a major chemotherapeutic agents. But,... -
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- Beyond angiogenesis blockade: targeted therapy for advanced cervical cancer
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Eskander R, Tewari KS
- KMID: 2130106
- J Gynecol Oncol.
- 2014 Jul;25(3):249-259.
- doi: 10.3802/jgo.2014.25.3.249
The global burden of advanced stage cervical cancer remains significant, particular in resource poor countries where effective screening programs are absent. Unfortunately, a proportion of patients will be diagnosed with... -
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- Clinical efficacy of erlotinib, a salvage treatment for non-small cell lung cancer patients following gefitinib failure
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Cho KM, Keam B, Kim TM, Lee SH, Kim DW, Heo DS
- KMID: 2381594
- Korean J Intern Med.
- 2015 Nov;30(6):891-898.
- doi: 10.3904/kjim.2015.30.6.891
BACKGROUND/AIMS: The purpose of this study was to identify predictive factors for erlotinib treatment in non-small cell lung cancer (NSCLC) patients following gefitinib failure. METHODS: Forty-five patients with NSCLC who were... -
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- Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells
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Jeong KJ, Park SY, Seo JH, Lee KB, Choi WS, Han JW, Kang JK, Park CG, Kim YK, Lee HY
- KMID: 1072941
- Exp Mol Med.
- 2008 Dec;40(6):607-616.
- doi: 10.3858/emm.2008.40.6.607
Lysophosphatidic acid (LPA) is a bioactive phospholipids and involves in various cellular events, including tumor cell migration. In the present study, we investigated LPA receptor and its transactivation to EGFR... -
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- Signaling pathway for 2,3,7,8-tetrachlorodibenzo- p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages
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Cheon HJ, Woo YS, Lee JY, Kim HS, Kim HJ, Cho S, Won NH, Sohn J
- KMID: 756076
- Exp Mol Med.
- 2007 Aug;39(4):524-534.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a prototypic halogenated aromatic hydrocarbon (HAH), is known as one of the most potent toxicants. At least a part of its toxic effects appears to be derived from... -
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- Could HBx Protein Expression Affect Signal Pathway Inhibition by Gefitinib or Selumetinib, a MEK Inhibitor, in Hepatocellular Carcinoma Cell Lines?
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Park YK, Kim KM, Lee YJ, Kim KH, Lee SG, Lee D, Shim JH, Lim YS, Lee HC, Chung YH, Lee YS, Suh DJ
- KMID: 1782109
- J Korean Med Sci.
- 2011 Feb;26(2):214-221.
- doi: 10.3346/jkms.2011.26.2.214
Hepatitis B virus X (HBx) protein has been known to play an important role in development of hepatocellular carcinoma (HCC). The aim of this study is to find out whether... -
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- The Impact of Cigarette Smoking on the Frequency of and Qualitative Differences in KRAS Mutations in Korean Patients with Lung Adenocarcinoma
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Kim HR, Ahn JR, Lee JG, Bang DH, Ha SJ, Hong YK, Kim SM, Nam KC, Rha SY, Soo RA, Riely GJ, Kim JH, Cho BC
- KMID: 2158219
- Yonsei Med J.
- 2013 Jul;54(4):865-874.
- doi: 10.3349/ymj.2013.54.4.865
PURPOSE: This study was designed to determine the relationship of cigarette smoking to the frequency and qualitative differences among KRAS mutations in lung adenocarcinomas from Korean patients. MATERIALS AND METHODS: Detailed... -
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- A Phase II Study of Cetuximab (Erbitux(R)) plus FOLFIRI for Irinotecan and Oxaliplatin-refractory Metastatic Colorectal Cancer
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Koo DH, Lee JL, Kim TW, Chang HM, Ryu MH, Lee SS, Kim MK, Sym SJ, Lee JS, Kang YK
- KMID: 1785796
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S98-S103.
- doi: 10.3346/jkms.2007.22.S.S98
We have evaluated the efficacy and safety of cetuximab plus FOLFIRI for irinotecan and oxaliplatin-refractory colorectal cancers. From September 2004 to February 2006, 31 patients with metastatic colorectal cancer were... -
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