- Depletion of mitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability
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Lee W, Choi HI, Kim MJ, Park SY
- KMID: 1103594
- Exp Mol Med.
- 2008 Feb;40(1):109-117.
- doi: 10.3858/emm.2008.40.1.109
The mutation and reduction of mitochondrial DNA (mtDNA) have been suggested as factors in the carcinogenesis. However, whether the depletion of mtDNA induces multidrug resistance in cancer cells has not... -
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- TGF-beta Suppresses COX-2 Expression by Tristetraprolin-Mediated RNA Destabilization in A549 Human Lung Cancer Cells
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Kang S, Min A, Im SA, Song SH, Kim SG, Kim HA, Kim HJ, Oh DY, Jong HS, Kim TY, Bang YJ
- KMID: 2380395
- Cancer Res Treat.
- 2015 Jan;47(1):101-109.
- doi: 10.4143/crt.2013.192
PURPOSE: Overexpression of cyclooxygenase 2 (COX-2) is thought to promote survival of transformed cells. Transforming growth factor beta (TGF-beta) exerts anti-proliferative effects on a broad range of epithelial cells. In... -
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- Depletion of Mitochondrial DNA Stabilizes C1qTNF-Related Protein 6 mRNA in Muscle Cells
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Kim MJ, Lee W, Park EJ, Park SY
- KMID: 1372785
- J Korean Med Sci.
- 2012 May;27(5):465-470.
- doi: 10.3346/jkms.2012.27.5.465
Mutation and reduction of mitochondrial DNA (mtDNA) have been suggested as factors in the pathogenesis of several metabolic diseases. Recently, we demonstrated that C1qTNF-related protein-6 (CTRP6) is involved in fatty... -
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- A Case of Steroid-induced Atrophy of External Genitalia
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Jeon JH, Park JM, Yoo EG, Kim DH
- KMID: 2144624
- J Korean Soc Pediatr Endocrinol.
- 2001 Dec;6(2):160-164.
Skin atrophy is one of the most common side effects of topical steroid use and results from decreased skin proalphaI collagen mRNA production due to specific alterations in collagen gene... -
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- The effect of interleukin-10 on KC gene expression in mouse peritoneal macrophages
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Kim HS
- KMID: 2154411
- Yeungnam Univ J Med.
- 1998 Jun;15(1):47-54.
- doi: 10.12701/yujm.1998.15.1.47
Interleukin-10(IL-10) inhibits production of a wide range of cytokines in various cell types and transcriptionally inhibits lipopolysaccharide(LPS)-induced expression of proinflammatory mediators. Cytokine expression by macrophages is an important aspect to... -
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- The Role of MicroRNAs in Oncogenesis and Progression of Prostate Cancer
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Kim WT, Yun SJ, Kim WJ
- KMID: 2439396
- Korean J Urol Oncol.
- 2018 Apr;16(1):1-6.
- doi: 10.22465/kjuo.2018.16.1.1
MicroRNAs (miRNAs) are small noncoding RNAs that target mRNA to reduce gene and protein expression by repressing their targets' translation or inducing mRNA degradation. They play fundamental roles in various... -
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- The Effect of Elapsed Time on the Quantity of mRNA in Skin: A Study to Evaluate the Potential Forensic Use of mRNA to Determine the Postmortem Interval
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Song HJ, Choi YL, Kang SY, Chae JM
- KMID: 2305474
- Korean J Leg Med.
- 2012 Nov;36(2):151-158.
- doi: 10.7580/KoreanJLegMed.2012.36.2.151
Ribonucleic acid (RNA) has potential use in forensic science for the determination of postmortem interval. We report the first study on serial sampling of messenger RNA (mRNA) from surgical specimens... -
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- Superoxide Dismutase Gene Expression Induced by Lipopolysaccharide in Alveolar Macrophage of Rat
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Park KY, Yoo CG, Kim YW, Han SK, Shim YS, Hyun IG
- KMID: 2317935
- Tuberc Respir Dis.
- 1995 Aug;42(4):522-534.
BACKGROUND: In the pathogenesis of acute lung injury induced by lipopolysaccharide(LPS), oxygen radiclls are known to be involved in one part. Superoxide dismutase(SOD) protects oxygen radical-induced tissue damage by dismutating... -
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- Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-alpha mRNA
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Chae MJ, Sung HY, Kim EH, Lee M, Kwak H, Chae CH, Kim S, Park WY
- KMID: 1122283
- Exp Mol Med.
- 2009 Nov;41(11):824-831.
- doi: 10.3858/emm.2009.41.11.088
Hu protein R (HuR) binds to the AU-rich element (ARE) in the 3'UTR to stabilize TNF-alpha mRNA. Here, we identified chemical inhibitors of the interaction between HuR and the ARE... -
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- ATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells
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Kim KJ, Lee J, Park Y, Lee SH
- KMID: 2380346
- Biomol Ther.
- 2015 Mar;23(2):134-140.
- doi: 10.4062/biomolther.2014.107
Conjugated linoleic acids (CLA) are a family of isomers of linoleic acid. CLA increases growth arrest and apoptosis of human colorectal cancer cells through an isomer-specific manner. ATF3 belongs to... -
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- Suppression of miR-155 Expression in IFN-gamma-Treated Astrocytes and Microglia by DJ-1: A Possible Mechanism for Maintaining SOCS1 Expression
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Kim JH, Jou I, Joe EH
- KMID: 2165515
- Exp Neurobiol.
- 2014 Jun;23(2):148-154.
- doi: 10.5607/en.2014.23.2.148
Previously, we reported that DJ-1, encoded by a Parkinson's disease (PD)-associated gene, inhibits expression of proinflammatory mediators in interferon-gamma (IFN-gamma)-treated astrocytes and microglia through inhibition of STAT1 activation. Here, using... -
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- Effect of BIS depletion on HSF1-dependent transcriptional activation in A549 non-small cell lung cancer cells
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Yun HH, Baek JY, Seo G, Kim YS, Ko JH, Lee JH
- KMID: 2414270
- Korean J Physiol Pharmacol.
- 2018 Jul;22(4):457-465.
- doi: 10.4196/kjpp.2018.22.4.457
The expression of BCL-2 interacting cell death suppressor (BIS), an anti-stress or anti-apoptotic protein, has been shown to be regulated at the transcriptional level by heat shock factor 1 (HSF1)... -
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- p21WAFI mRNA Expression During HL60 Cell Differentiation
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Suh SI, Jung JA, Cho JW, Park MH, Paik SD, Suh WK, Suh MH
- KMID: 2001268
- J Korean Soc Microbiol.
- 1997 Aug;32(4):455-466.
p21waf1 is the mammalian cyclin-dependent kinase (CDK) inhibitor to be discovered. p21waf1 which is found to be induced by p53 mediates growth arrest by inhibiting G1 CDKs. But, recently p21waf1... -
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- Down-regulation of IL-1beta-induced COX-2 Expression in A549 Lung Cancer Cells at Transcriptional Level by Leptomycin B Involves Inhibition of the IkappaB-alpha/NF-kappaB Pathway but Independent of CRM1
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Park CK, Kim JB, Keum DY, Jang BC
- KMID: 2200170
- J Lung Cancer.
- 2006 Dec;5(2):102-110.
- doi: 10.6058/jlc.2006.5.2.102
PURPOSE: Overexpression of COX-2, an enzyme responsible fro the synthesis of prostaglandins, is well linked to human chronic lung diseases. The mechanism by which COX-2 expression is increased or enhanced... -
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- Analysis of the Gene Expression by Laser Captured Microdissection (I): Minimum Conditions Required for the RNA Extraction from Oocytes and Amplification for RT-PCR
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Park CE, Ko JJ, Cha KY, Lee KA
- KMID: 1979128
- Korean J Fertil Steril.
- 2001 Sep;28(3):183-190.
OBJECTIVE: Recently, microdissection of tissue sections has been used increasingly for the isolation of morphologically identified homogeneous cell populations, thus overcoming the obstacle of tissue complexity for the analysis cell-specific... -
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- Inhibition of Inducible Nitric Oxide Synthase Expression by YS 49, a Synthetic Isoquinoline Alkaloid, in ROS 17/2.8 Cells Activated with TNF-alpha, IFN-gamma and LPS
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Kang YJ, Kang SY, Lee YS, Park MK, Kim HJ, Seo HG, Lee JH, Yun-Choi H, Chang KC
- KMID: 1611431
- Korean J Physiol Pharmacol.
- 2004 Oct;8(5):273-280.
Nitric oxide (NO) has been suggested to act as a mediator of cytokine-induced effects of turn over of bone. Activation of the inducible nitric oxide synthase (iNOS) by inflammation has... -
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- The Pathogenetic Role of TAR DNA Binding Protein (TDP-43) in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
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Kang SY
- KMID: 2065761
- J Korean Neurol Assoc.
- 2011 Feb;29(1):1-8.
The recent identification of the transactive response DNA binding protein with a molecular weight of 43 kDa (TDP-43) as the major pathological protein, in both amyotrophic lateral sclerosis (ALS) and... -
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- Expression of Exon 1 and 6 of Indulin-like Growth Factor - 1 (IGF - 1) Gene in Thyroid Tissues
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Kim SW, Chang HH, Jung IK, Woo JT, Yang IM, Kim JW, Kim SS, Choi YK
- KMID: 2461651
- J Korean Soc Endocrinol.
- 1996 Dec;11(4):409-417.
Background: Goiter has been a common problem in the thyroid disease. The exact mechanism of goiter had not been clarified yet, but some goiters were increased with TSH(thyrotropin releasing hormone)... -
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- Effect of Transforming Growth Factor-beta1 (TGF-beta1) on the Expression of Vascular cell Adhesion Molecule-1 (VCAM-1) in Cultured Human Peritoneal Mesothelial Cells (HPMCs)
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Jung HH, Yang WS, Kim SB, Kim BS, Park SK, Park JS
- KMID: 1989639
- Korean J Nephrol.
- 2002 Nov;21(6):956-965.
BACKGROUND: In early phase of peritonitis, mononuclear cells as well as polymorphonuclear leukocytes migrate rapidly into peritoneal cavity. For the migration of mononuclear cells, the expression of VCAM-1 on peritoneal... -
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- Involvement of Human Histamine N-Methyltransferase Gene Polymorphisms in Susceptibility to Atopic Dermatitis in Korean Children
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Lee HS, Kim SH, Kim KW, Baek JY, Park HS, Lee KE, Hong JY, Kim MN, Heo WI, Sohn MH, Kim KE
- KMID: 2130376
- Allergy Asthma Immunol Res.
- 2012 Jan;4(1):31-36.
- doi: 10.4168/aair.2012.4.1.31
PURPOSE: Histamine N-methyltransferase (HNMT) catalyzes one of two major histamine metabolic pathways. Histamine is a mediator of pruritus in atopic dermatitis (AD). The aim of this study was to evaluate... -
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