- Thalidomide Accelerates the Degradation of Extracellular Matrix in Rat Hepatic Cirrhosis via Down-Regulation of Transforming Growth Factor-beta1
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Lv P, Meng Q, Liu J, Wang C
- KMID: 2345885
- Yonsei Med J.
- 2015 Nov;56(6):1572-1581.
- doi: 10.3349/ymj.2015.56.6.1572
PURPOSE: The degradation of the extracellular matrix has been shown to play an important role in the treatment of hepatic cirrhosis. In this study, the effect of thalidomide on the... -
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- Real-Time PCR analysis of af4 and dek genes expression in acute promyelocytic leukemiat (15;17)patients
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Savli H, Sirma S, Nagy B, Aktan M, Dincol G, Salcioglu , Sarper N, Ozbek U
- KMID: 1097111
- Exp Mol Med.
- 2004 Jun;36(3):279-282.
Among several newly identified oncogenes, dek and af4 are attractive targets for researchers interested with leukemia. In this study quantitative Real-Time RT-PCR technique was used to define alterations in expression... -
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- Ongoing angiogenesis in blood vessels of the abdominal aortic aneurysm
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Paik DC, Fu C, Bhattacharya J, David Tilson M
- KMID: 1103319
- Exp Mol Med.
- 2004 Dec;36(6):524-533.
Pathogenesis of the abdominal aortic aneurysm has been attributed to neovascularization of the aortic wall. However, it is not clear whether angiogenesis persists in the aneurysm. In sections of aneurysms,... -
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- Growth impairment of primary chondrocyte cells by serum of rats with chronic renal failure
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Mak RH, Chang SL, Pak YK
- KMID: 1097106
- Exp Mol Med.
- 2004 Jun;36(3):243-250.
Insulin-like growth factor (IGF)/IGF binding protein (IGFBP) abnormalities may be important in the pathogenesis of growth failure in chronic renal failure (CRF). We induced experimental CRF by 5/6 nephrectomy in... -
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- Regulation of glutamate level in rat brain through activation of glutamate dehydrogenase by Corydalis ternata
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Lee KH, Huh JW, Choi MM, Yoon SY, Yang SJ, Hong HN, Cho SW
- KMID: 1093472
- Exp Mol Med.
- 2005 Aug;37(4):371-377.
When treated with protopine and alkalized extracts of the tuber of Corydalis ternata for one year, significant decrease in glutamate level and increase in glutamate dehydrogenase (GDH) activity was observed... -
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- Gene expression in uremic left ventricular hypertrophy: effects of hypertension andanemia
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Mak RH, Chang SL, Draksharapu A, Pak YK
- KMID: 1097107
- Exp Mol Med.
- 2004 Jun;36(3):251-258.
Hypertension and anemia may be causes of left ventricular hypertrophy (LVH) in uremia but the molecular mechanism is not known. Uremia was induced in male Spraugue Dawley rats by 5/6... -
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- Protein kinase A mediates microglial activation induced by plasminogen and gangliosides
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Min KJ, Yang MS, Jou I, Joe EH
- KMID: 1123767
- Exp Mol Med.
- 2004 Oct;36(5):461-467.
In the injured brain, microglia is known to be activated and produce proinflammatory mediators such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS). We investigated... -
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- Representational difference analysis of cDNA identifies novel genes expressed following preconditioning of the heart
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Fauchon MA, Pell TJ, Baxter GF, Yellon DM, Latchman D, Hubank MF, Mayn LV
- KMID: 1093466
- Exp Mol Med.
- 2005 Aug;37(4):311-322.
Preconditioning of the myocardium rapidly induces a number of transcription factors, which are likely to be responsible for a cascade of transcriptional changes underlying the development of delayed adaptation. Identifying... -
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- Transforming variant of Met receptor confers serum independence and anti-apoptotic property and could be involved in the mouse thymic lymphomagenesis
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Baek CM, Jeon SH, Jang JJ, Lee BS, Lee JH
- KMID: 1094072
- Exp Mol Med.
- 2004 Aug;36(4):283-291.
Met tyrosine kinase receptor, the receptor of hepatocyte growth factor/scatter factor (HGF/SF), is present in mouse tissues as two major isoforms differing by a 47-aminoacid segment in the juxtamembrane domain... -
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- Cellular characteristics of primary and immortal canine embryonic fibroblast cells
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You S, Moon JH, Kim TK, Kim SC, Kim JW, Yoon DH, Kwak S, Hong KC, Choi YJ, Kim H
- KMID: 1094076
- Exp Mol Med.
- 2004 Aug;36(4):325-335.
Using normal canine embryonic fibroblasts (CaEF) that were shown to be senescent at passages 7th-9th, we established two spontaneously immortalized CaEF cell lines (designated CGFR-Ca-1 and -2) from normal senescent... -
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- Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-gamma
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Lee KJ, Kim HA, Kim PH, Lee HS, Ma KR, Park JH, Kim DJ, Hahn JH
- KMID: 1103320
- Exp Mol Med.
- 2004 Dec;36(6):534-544.
During chronic inflammatory response, mono- cytes/macrophages produce 92-kDa matrix metalloproteinase-9 (MMP-9), which may contribute to their extravasation, migration and tissue remodeling. Activation of peroxisome proliferator- activated factor receptor-gamma (PPAR-gamma) has... -
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