- Understanding Disease Susceptibility through Population Genomics
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Han S, Lee J, Kim S
- KMID: 2053302
- Genomics Inform.
- 2012 Dec;10(4):234-238.
- doi: 10.5808/GI.2012.10.4.234
Genetic epidemiology studies have established that the natural variation of gene expression profiles is heritable and has genetic bases. A number of proximal and remote DNA variations, known as expression... -
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- Investigation of Splicing Quantitative Trait Loci in Arabidopsis thaliana
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Yoo W, Kyung S, Han S, Kim S
- KMID: 2366438
- Genomics Inform.
- 2016 Dec;14(4):211-215.
- doi: 10.5808/GI.2016.14.4.211
The alteration of alternative splicing patterns has an effect on the quantification of functional proteins, leading to phenotype variation. The splicing quantitative trait locus (sQTL) is one of the main... -
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- Genetic Architecture of Transcription and Chromatin Regulation
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Kim K, Bang H, Lee K, Choi JK
- KMID: 2009145
- Genomics Inform.
- 2015 Jun;13(2):40-44.
- doi: 10.5808/GI.2015.13.2.40
DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic... -
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- Genome-Wide Association Study of Metabolic Syndrome in Koreans
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Jeong SW, Chung M, Park SJ, Cho SB, Hong KW
- KMID: 2391495
- Genomics Inform.
- 2014 Dec;12(4):187-194.
- doi: 10.5808/GI.2014.12.4.187
Metabolic syndrome (METS) is a disorder of energy utilization and storage and increases the risk of developing cardiovascular disease and diabetes. To identify the genetic risk factors of METS, we... -
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- Analysis of genetic and non-genetic factors that affect the QTc interval in a Mongolian population: the GENDISCAN study
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Im SW, Lee MK, Lee HJ, Oh SI, Kim HL, Sung J, Cho SI, Seo JS, Kim JI
- KMID: 1122285
- Exp Mol Med.
- 2009 Nov;41(11):841-848.
- doi: 10.3858/emm.2009.41.11.090
The QTc interval is a complex quantitative trait and a strong prognostic indicator of cardiovascular mortality in general, healthy people. The aim of this study was to identify non-genetic factors... -
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- Localization of Quantitative Trait Loci for Bone Mineral Density on Chromosome 13 in the Mongolian Population
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Seo SH, Lim HJ, Ahn S, Lee J, Kim JI
- KMID: 1469574
- Genomics Inform.
- 2009 Sep;7(3):152-158.
Although the genetic basis for bone mineral density (BMD) has been studied by many groups so far, genes responsible for this complex trait has not been completely revealed. In order... -
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- Molecular Genetics of Cholesterol Gallstone Disease; LITH Genes
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Dong SH
- KMID: 2168080
- Hanyang Med Rev.
- 2007 Feb;27(1):29-34.
Cholesterol gallstone formation is influenced by environmental and genetic factors. Cholesterol gallstone susceptible genes (Lith genes) are complex and show polygenic traits. Quantitative trait locus (QTL) analysis in inbred mice... -
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- Genome-Wide Association Studies Associated with Backfat Thickness in Landrace and Yorkshire Pigs
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Lee YS, Shin D
- KMID: 2422813
- Genomics Inform.
- 2018 Sep;16(3):59-64.
- doi: 10.5808/GI.2018.16.3.59
Although pork quality traits are important commercially, genome-wide association studies (GWASs) have not well considered Landrace and Yorkshire pigs worldwide. Landrace and Yorkshire pigs are important pork-providing breeds. Although quantitative... -
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- Genome-wide linkage analysis for ocular and nasal anthropometric traits in a Mongolian population
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Im SW, Kim HJ, Lee MK, Yi JH, Jargal G, Sung J, Cho SI, Kim JI
- KMID: 1115263
- Exp Mol Med.
- 2010 Dec;42(12):799-804.
- doi: 10.3858/emm.2010.42.12.080
Anthropometric traits for eyes and nose are complex quantitative traits influenced by genetic and environmental factors. To date, there have been few reports on the contribution of genetic influence to... -
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- Linkage Disequilibrium Analysis of Quantitative Trait Locus Associated with Lipid Profiles
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Song K, Lim KS, Cho JN, Jang YS, Park HY
- KMID: 2029031
- Korean Circ J.
- 2006 Oct;36(10):688-694.
- doi: 10.4070/kcj.2006.36.10.688
BACKGROUND AND OBJECTIVES : The common methods of genetic association analysis are sensitive to population stratification, which may easily lead to a spurious association result. We used a regression approach... -
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- Current status of genomic prediction using Multi-omics data in livestock
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An NR, Lee SS, Park JE, Chai HH, Cho YM, Lim D
- KMID: 2405360
- J Biomed Transl Res.
- 2017 Dec;18(4):151-156.
- doi: 10.12729/jbtr.2017.18.4.151
It became possible to perform genomic predictions using single nucleotide polymorphism (SNP) with advancements in genomics technology, not only in human but in livestock as well. There are strong interests... -
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- Genome-Wide Analysis Reveals Four Novel Loci for Attention-Deficit Hyperactivity Disorder in Korean Youths
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Kweon K, Shin ES, Park KJ, Lee JK, Joo Y, Kim HW
- KMID: 2409861
- J Korean Acad Child Adolesc Psychiatry.
- 2018 Apr;29(2):62-72.
- doi: 10.5765/jkacap.2018.29.2.62
OBJECTIVES: The molecular mechanisms underlying attention-deficit hyperactivity disorder (ADHD) remain unclear. Therefore, this study aimed to identify the genetic susceptibility loci for ADHD in Korean children with ADHD. We performed... -
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- Heritability and linkage study on heart rates in a Mongolian population
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Gombojav B, Park H, Kim JI, Ju YS, Sung J, Cho SI, Lee MK, Ohrr H, Radnaabazar J, Seo JS
- KMID: 1104810
- Exp Mol Med.
- 2008 Oct;40(5):558-564.
- doi: 10.3858/emm.2008.40.5.558
Elevated heart rate has been proposed as an independent risk factor for cardiovascular diseases, but their interrelationships are not well understood. In this study, we performed a genome-wide linkage scan... -
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- Linkage between gene marker of chromosome 11q13 and IgE - receptor mediated basophil histamine release
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Kim YK, Cho SH, Koh YY, Son JW, Min KU, Kim YY
- KMID: 2080694
- Korean J Med.
- 1999 Mar;56(3):359-366.
OBJECTIVE: To evaluate that genetic factor(s) in chromosome 11q13 may control the expression of basophil histamine release (BaHR) after anti-IgE stimuli, linkage analysis between this phenotype and gene marker of chromosome 11q13... -
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- Linkage analysis between gene marker of chromosome 11q13 and total serum IgE level in sib - pairs with probands of asthmatic children
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Kim YK, Son JW, Cho SH, Lee MH, Koh YY, Min KU, Kim YY
- KMID: 2286138
- J Asthma Allergy Clin Immunol.
- 1998 Sep;18(3):473-482.
BACKGROUND: It is known that total serum IgE levels closely corrleate with prevaience of asthma regardless of atopic status. Although heredity is reported to be important in expression of total serum IgE... -
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- Methylation Profiles of CpG Island Loci in Major Types of Human Cancers
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Park SY, Kim BH, Kim JH, Cho NY, Choi M, Yu EJ, Lee S, Kang GH
- KMID: 1713193
- J Korean Med Sci.
- 2007 Apr;22(2):311-317.
- doi: 10.3346/jkms.2007.22.2.311
Several reports have described aberrant methylation in various types of human cancers. However, the interpretation of methylation frequency in various human cancers has some limitations because of the different materials... -
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- Linkage analysis between gene marker of chromosome 11q13, and skin reactivity to common inhalant allergens and bronchial responsiveness in sib-pairs with probands of asthmatic children
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Kim YK, Son JW, Cho SH, Lee MH, Koh YY, Min KU, Kim YY
- KMID: 2286109
- J Asthma Allergy Clin Immunol.
- 1998 Dec;18(4):689-700.
BACKGROUND: Increased IgE antibody responses to inhalant allergens and bronchial hyperresponsiveness are important phenotypes in development of asthma. Although heredity reported to be important in expression of these phenotypes in twin and... -
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- Combined Genome-Wide Linkage and Association Analyses of Fasting Glucose Level in Healthy Twins and Families of Korea
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Suh YJ, Kim S, Kim SH, Park J, Lim HA, Park HJ, Choi H, Ng D, Lee MK, Nam M
- KMID: 1786940
- J Korean Med Sci.
- 2013 Mar;28(3):415-423.
- doi: 10.3346/jkms.2013.28.3.415
This study was undertaken to identify genetic polymorphisms that are associated with the risk of an elevated fasting glucose (FG) level using genome-wide analyses. We explored a quantitative trait locus... -
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