J Asthma Allergy Clin Immunol.
1998 Sep;18(3):473-482.
Linkage analysis between gene marker of chromosome 11q13 and total serum IgE level in sib - pairs with probands of asthmatic children
Abstract
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BACKGROUND: It is known that total serum IgE levels closely corrleate with prevaience of
asthma regardless of atopic status. Although heredity is reported to be important in
expression of total serum IgE in twin studies, genetic factor controlling this phenotype
is controversial. Objective .' To evaluate whether genetic factor in chromosome 1 1q13 may
control the expression of tatal serum IgE level, linkage analysis between this phenotype
and gene marker of chromosome 11q13 was investigated.
MATERIAL AND METHOD: Total serum IgE level and the genotype of chromosome 11q13 with
microsatellite marker (D11597) was determined in 73 probands of asthmatic chiMren and
76 their sibs. Statistical significance of linkage was evaluated by affected and quantitative
trait locus (QTL) sib-pair analysis.
RESULT: In 20 affected sib-pairs with total serum IgE level higher than 305 IU/ml
(geometric mean plus two folds SD in 53 normal controls), two D11S97 alleles were shared
by ten sib-pairs, one allele by nine sib-pairs, and no allele by one sib-pairs. Sharing
rate of the alleles in affect,ed sib-pairs, was 72.5%, which indicates linkage of the
phenotype and genotype (x=4. 27, p=0.03). In 35 sib-pairs with total serum IgE level
higher than 170 IU/ml (geometric mean plus one fold SD in 53 normal controls),
two D11S97 alleles were shared by 16 sib-pairs, one allele by 15 sib-pairs, and
no allele by four sib-pairs. The shar ing rate of the alleles in affected sibpairs,
was 67.1%, which indicates linkage of the phenotype and the genotype(x=4. 24, p=0.03).
Difference of geometric value of total serum IgE levels between probands and their sibs
wa,s smaller in 32 sib-pairs sharing two alleles than in 32 those sharing one allele and
12 those with no identical allele (0.45+0.07 vs. 0.52+0.07 vs. 0.89 +0.21).
CONCLUSION
The expression of total serum IgE level was linked to gene marker of chromosome 11q13.
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