Exp Mol Med.
2008 Oct;40(5):558-564. 10.3858/emm.2008.40.5.558.
Heritability and linkage study on heart rates in a Mongolian population
- Affiliations
-
- 1Department of Public Health, The Graduate School, Yonsei University, Seoul, Korea.
- 2Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Korea. jeongsun@snu.ac.kr
- 3ILCHUN Genomic Medicine Institute Medical Research Center, Seoul National University, Korea.
- 4Department of Epidemiology, School of Public Health and Institute for Health and Environment, Seoul National University, Korea.
- 5PSOMA therapeutics Inc, Seoul, Korea.
- 6Department of Preventive Medicine and Public Health, Yonsei University College of Medicine, Seoul, Korea.
- 7State Research Center on Maternal and Child Health, Ulaanbaatar, Mongolia.
- KMID: 1104810
- DOI: http://doi.org/10.3858/emm.2008.40.5.558
Abstract
- Elevated heart rate has been proposed as an independent risk factor for cardiovascular diseases, but their interrelationships are not well understood. In this study, we performed a genome-wide linkage scan in 1,026 individuals (mean age 30.6 years, 54.5% women) from 73 extended families of Mongolia and determined quantitative trait loci that influence heart rate. The DNA samples were genotyped using deCODE 1,039 microsatellite markers for 3 cM density genome-wide linkage scan. Correlation analysis was carried out to evaluate the correlation of the covariates and the heart rate. T-tests of the heart rate were also performed on sex, smoking and alcohol intake. Consequently, this model was used in a nonparametric genome-wide linkage analysis using variance component model to create a multipoint logarithm of odds (LOD) score and a corresponding P value. In the adjusted model, the heritability of heart rate was estimated as 0.32 (P<.0001) and a maximum multipoint LOD score of 2.03 was observed in 77 cM region at chromosome 18. The second largest LOD score of 1.52 was seen on chromosome 5 at 216 cM. Genes located on the specified locations in chromosomes 5 and 18 may be involved in the regulation of heart rate.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Genome-wide Linkage Study for Plasma HDL Cholesterol Level in an Isolated Population of Mongolia
- Genome-wide linkage analysis for ocular and nasal anthropometric traits in a Mongolian population
- Analysis of genetic and non-genetic factors that affect the QTc interval in a Mongolian population: the GENDISCAN study
- Heritability and Familiality of Temperament and Character Dimensions in Korean Families with Schizophrenic Linkage Disequilibrium
- Localization of Quantitative Trait Loci for Bone Mineral Density on Chromosome 13 in the Mongolian Population
