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Acidic pH-activated Cl- Current and Intracellular Ca2+ Response in Human Keratinocytes

Park SJ, Choi WW, Kwon OS, Chung JH, Eun HC, Earm YE, Kim SJ

The layers of keratinocytes form an acid mantle on the surface of the skin. Herein, we investigated the effects of acidic pH on the membrane current and [Ca2+](c) of human...
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Myoclonus, Delayed Sequelae of Carbon Monoxide Poisoning, Piracetam Trial

Kim JS, Lee SA, Kim JS

One month following carbon monoxide poisoning, a 39 year-old man developed incontinence, memory impairment, disorientation and emotional instability. He was hospitalized 7weeks later, and during hospitalization he exhibited myoclonic movements...
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Unexpected effects of pathogens on epithelial Na+ channels

Kunzelmann K, Beesley A, King N, Karupiah G, Young J, Cook D

No abstract available.
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Activation of Lysophosphatidic Acid Receptor Is Coupled to Enhancement of Ca(2+)-Activated Potassium Channel Currents

Choi SH, Lee BH, Kim HJ, Hwang SH, Lee SM, Nah SY

The calcium-activated K+ (BKCa) channel is one of the potassium-selective ion channels that are present in the nervous and vascular systems. Ca2+ is the main regulator of BKCa channel activation....
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First Isolation of Streptococcus gallolyticus subsp. pasteurianus from a Korean Patient with Severe Septic Shock

Jeong S, Park JY, Han SH, Lee Y, Yong D, Lee K, Chong Y

A 60-year-old man presented with a 1-day history of fever, vomiting, and diarrhea. He was diagnosed with severe septic shock on the basis of a body temperature of 38.9degrees C,...
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Oxidized Low-density Lipoprotein- and Lysophosphatidylcholine-induced Ca2+ Mobilization in Human Endothelial Cells

Kim MY, Liang GH, Kim JA, Choi SS, Choi S, Suh SH

The effects of oxidized low-density lipoprotein (OxLDL) and its major lipid constituent lysophosphatidylcholine (LPC) on Ca2+ entry were investigated in cultured human umbilical endothelial cells (HUVECs) using fura-2 fluorescence and...
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Signaling Pathway of Lysophosphatidic Acid-Induced Contraction in Feline Esophageal Smooth Muscle Cells

Nam YS, Suh JS, Song HJ, Sohn UD

Lysolipids such as LPA, S1P and SPC have diverse biological activities including cell proliferation, differentiation, and migration. We investigated signaling pathways of LPA-induced contraction in feline esophageal smooth muscle cells....
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Effects of Histamine on Cultured Interstitial Cells of Cajal in Murine Small Intestine

Kim BJ, Kwon YK, Kim E, So I

Interstitial cells of Cajal (ICCs) are the pacemaker cells in the gastrointestinal tract, and histamine is known to regulate neuronal activity, control vascular tone, alter endothelial permeability, and modulate gastric...
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Dexmedetomidine-induced contraction of isolated rat aorta is dependent on extracellular calcium concentration

Ok SH, Bae SI, Shim HS, Sohn JT

BACKGROUND: Dexmedetomidine is a highly selective alpha2-adrenoceptor agonist that is widely used for sedation and analgesia during the perioperative period. Intravenous administration of dexmedetomidine induces transient hypertension due to vasoconstriction...
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Effects of Inositol 1,4,5-triphosphate on Osteoclast Differentiation in RANKL-induced Osteoclastogenesis

Son A, Kim MS, Jo H, Byun HM, Shin DM

The receptor activator of NF-kappaB ligand (RANKL) signal is an activator of tumor necrosis factor receptor-associated factor 6 (TRAF6), which leads to the activation of NF-kappaB and other signal transduction...
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Age-dependent Kisspeptin Effects on the GnRH Neurons in Male and Female Mice

Bhattarai , Park SA, Yin H, Park SJ, Jeon JG, Chang KW, Lee SY, Ryu PD, Han SK

BACKGROUND: The gonadotropin releasing hormone (GnRH) neurons play a pivotal role in the central regulation of fertility. Kisspeptin binds to the G-protein coupled receptor 54 (GPR54) and GPR54 has been...
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Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCalpha-ERK pathway

Park MH, Lee DH

Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and...
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Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine.

Shah BH, Rasheed H, Rahman IH, Shariff AH, Khan FL, Rahman HB, Hanif S, Saeed SA

  • KMID: 1457534
  • Exp Mol Med.
  • 2001 Dec;33(4):226-233.
Our recent studies have shown that co-activation of Gq and Gi proteins by 5-hydroxytryptamine (5-HT) and adrenaline show synergism in human platelet aggregation. This study was conducted to examine the...
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Phytosphingosine-1-phosphate stimulates chemotactic migration of L2071 mouse fibroblasts via pertussis toxin-sensitive G-proteins

Kim MK, Park KS, Lee H, Kim YD, Yun J, Bae YS

  • KMID: 1094659
  • Exp Mol Med.
  • 2007 Apr;39(2):185-194.
Phytosphingosine-1-phosphate (PhS1P) was found to stimulate an intracellular calcium increase via phospholipase C but not pertussis toxin (PTX)- sensitive G-proteins in L2071 mouse fibroblasts. PhS1P also activated ERK and p38...
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Interleukin-1beta promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways

Lim JH, Um HJ, Park JW, Lee IK, Kwon TK

Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this...
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