- Differential Physiological Effects of Raf-1 Kinase Pathways Linked to Protein Kinase C Activation Depending on the Stimulus in v-H-ras-transformed Cells
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Lee M
- KMID: 2166000
- Cancer Res Treat.
- 2008 Jun;40(2):39-44.
PURPOSE: We investigated the molecular mechanism by which the Raf-1 kinase pathways that are linked to protein kinase C induce differential physiological effects, depending on the stimulus, by employing the... -
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- The Difference in Biological Properties between Parental and v-Ha-ras Transformed NIH3T3 Cells
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Lee M, Ahn JH, Eum KH
- KMID: 2165985
- Cancer Res Treat.
- 2009 Jun;41(2):93-99.
PURPOSE: We performed experiments to investigate the change in cellular signaling that occurs during the transformation of a normal cell to a cell capable of cancerous growth, and we did... -
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- Expression of Raf-1 Kinase Inhibitory Protein in Extrahepatic Bile Duct Carcinoma
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Kim HS, Kim GY, Lim SJ, Kim YW
- KMID: 1837526
- Korean J Pathol.
- 2010 Jun;44(3):234-242.
BACKGROUND: Raf-1 kinase inhibitory protein (RKIP) recently has been identified as a metastasis suppressor in a variety of human carcinomas. The prognostic significance of RKIP expression in extrahepatic bile duct... -
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- Molecular targeting for treatment of advanced hepatocellular carcinoma
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Song IH
- KMID: 1374958
- Korean J Hepatol.
- 2009 Sep;15(3):299-308.
- doi: 10.3350/kjhep.2009.15.3.299
Hepatocellular carcinoma (HCC) is a major global health problem, which has a grave morbidity and mortality. Over the past few decades, no effective systemic therapeutic modalities have been established for... -
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- Induction of Resistance to BRAF Inhibitor Is Associated with the Inability of Spry2 to Inhibit BRAF-V600E Activity in BRAF Mutant Cells
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Ahn JH, Han BI, Lee M
- KMID: 2382360
- Biomol Ther.
- 2015 Jul;23(4):320-326.
- doi: 10.4062/biomolther.2015.007
The clinical benefits of oncogenic BRAF inhibitor therapies are limited by the emergence of drug resistance. In this study, we investigated the role of a negative regulator of the MAPK... -
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- Multiple Signaling Pathways Contribute to the Thrombin-induced Secretory Phenotype in Vascular Smooth Muscle Cells
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Jeong JY, Son Y, Kim BY, Eo SK, Rhim BY, Kim K
- KMID: 2070795
- Korean J Physiol Pharmacol.
- 2015 Nov;19(6):549-555.
- doi: 10.4196/kjpp.2015.19.6.549
We attempted to investigate molecular mechanisms underlying phenotypic change of vascular smooth muscle cells (VSMCs) by determining signaling molecules involved in chemokine production. Treatment of human aortic smooth muscle cells... -
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- Molecular assembly of mitogen-activated protein kinase module in ras-transformed NIH3T3 cell line
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Park KS, Kim JA, Chai KJ
- KMID: 755075
- Exp Mol Med.
- 2000 Sep;32(3):120-126.
The ras, is a G-like protein that controls the mitogen-activated protein kinase (MAPK) pathway involved in control and differentiation of cell growth. MAPK is a key component of its... -
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- Cellular Proliferative Effect of Dexamethasone in Immortalized Trabecular Meshwork Cell (TM5) Line
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Jeon JW, Lee SJ, Kim JB, Kang JJ, Lee JH, Seong GJ, Kim EK
- KMID: 1779480
- Yonsei Med J.
- 2003 Apr;44(2):299-306.
- doi: 10.3349/ymj.2003.44.2.299
Dexamethasone (DEX), one of the corticosteroid hormones, is one of the most common therapeutic strategies in ophthalmological treatment. Despite its widespread use and clinical efficiency, little is known regarding the... -
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