- Mutation Profile of Well-Differentiated Thyroid Cancer in Asians
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Song YS, Lim JA, Park YJ
- KMID: 2407074
- Endocrinol Metab.
- 2015 Sep;30(3):252-262.
- doi: 10.3803/EnM.2015.30.3.252
Recent advances in molecular diagnostics have led to significant insights into the genetic basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the vast majority are associated... -
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- Discrepant Results for BRAF V600E Mutation Among Different Specimens in a Case of Hairy Cell Leukemia
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Moon HW, Hur M, Han SH, Yun YM, Kim SY
- KMID: 1707241
- Ann Lab Med.
- 2013 Jul;33(4):300-303.
- doi: 10.3343/alm.2013.33.4.300
No abstract available. -
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- Pathogenesis and Management of Serrated Polyps: Current Status and Future Directions
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Anderson J
- KMID: 2070073
- Gut Liver.
- 2014 Nov;8(6):582-589.
- doi: 10.5009/gnl14248
Hyperplastic or serrated polyps were once believed to have little to no clinical significance. A subset of these polyps are now considered to be precursors to colorectal cancers (CRC) in... -
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- Mouse Models as a Tool for Understanding Progression in Braf(V600E)-Driven Thyroid Cancers
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Landa I, Knauf JA
- KMID: 2441674
- Endocrinol Metab.
- 2019 Mar;34(1):11-22.
- doi: 10.3803/EnM.2019.34.1.11
The development of next generation sequencing (NGS) has led to marked advancement of our understanding of genetic events mediating the initiation and progression of thyroid cancers. The NGS studies have... -
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- The Clinical Significance of the BRAF Mutation in Patients with Papillary Thyroid Cancer
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Kim SJ, Lee J, Soh EY
- KMID: 2397995
- J Endocr Surg.
- 2017 Dec;17(4):175-183.
- doi: 10.16956/jes.2017.17.4.175
PURPOSE: Papillary thyroid cancer (PTC) is the most frequent subtype among thyroid cancers. B-type Raf kinase (BRAF) mutation can be found in approximately 80% of patients with PTC in Korea.... -
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- Anaplastic Transformation of Papillary Thyroid Carcinoma in a Young Man: A Case Study with Immunohistochemical and BRAF Analysis
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Park JH, Kwon HJ, Park CS, Hong S
- KMID: 2277388
- Korean J Pathol.
- 2014 Jun;48(3):234-240.
This study reports a case of anaplastic transformation from a well-differentiated thyroid carcinoma in a young patient. The first recurrent tissue contained poorly differentiated foci that revealed lower thyroglobulin, thyroid... -
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- BRAF V600E and MAP2K1 Mutations in Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma Cases
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Shin SY, Lee ST, Kim HJ, Ki CS, Jung CW, Kim JW, Kim SH
- KMID: 2363190
- Ann Lab Med.
- 2015 Mar;35(2):257-259.
- doi: 10.3343/alm.2015.35.2.257
No abstract available. -
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- Molecular targeting for treatment of advanced hepatocellular carcinoma
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Song IH
- KMID: 1374958
- Korean J Hepatol.
- 2009 Sep;15(3):299-308.
- doi: 10.3350/kjhep.2009.15.3.299
Hepatocellular carcinoma (HCC) is a major global health problem, which has a grave morbidity and mortality. Over the past few decades, no effective systemic therapeutic modalities have been established for... -
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- Model Development of Papillary Thyroid Carcinoma by BRAFV600E Transgenic Mice
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Lee JU, Joung KH, Jo YS, Shong M
- KMID: 2012969
- J Korean Thyroid Assoc.
- 2011 May;4(1):30-38.
BACKGROUND AND OBJECTIVES: The BRAFV600E mutation has been regarded as the leading cause of papillary thyroid cancer (PTC). However, the multi-step carcinogenic process induced by BRAFV600E has been remained to... -
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- HIF-1alpha Expression in BRAF(V600E)-Positive Papillary Thyroid Microcarcinoma
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Lee JU, Kim KS, Sul HJ, Lee DH, Lee KJ, Shong M, Jo YS
- KMID: 2198459
- J Korean Thyroid Assoc.
- 2011 Nov;4(2):102-108.
BACKGROUND AND OBJECTIVES: Recent studies have reported that vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF)-1alpha are up-regulated in BRAF(V600E)-positive papillary thyroid carcinoma (PTC). We investigated whether papillary thyroid... -
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- Imaging and Clinical Features of Thyroid Cancer in Children and Adolescents
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Lee KY, Hong HS, Lee EH, Yi BH, Lee HK, Lee YW, Koh ES
- KMID: 1443483
- J Korean Soc Radiol.
- 2011 Aug;65(2):181-189.
- doi: 10.3348/jksr.2011.65.2.181
PURPOSE: To evaluate clinical and imaging features of pediatric thyroid cancer, including BRAFV600E mutation status in papillary thyroid cancer (PTC). MATERIALS AND METHODS: We evaluated clinical findings including BRAF(V600E) status, ultrasound... -
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- Lack of Aberrant Methylation in an Adjacent Area of Left-Sided Colorectal Cancer
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Sambuudash O, Kim HS, Cho MY
- KMID: 2419080
- Yonsei Med J.
- 2017 Jul;58(4):749-755.
- doi: 10.3349/ymj.2017.58.4.749
PURPOSE: The molecular nature and the rate-limiting step of epigenetic field defects in the evolution of left-sided colorectal cancer (LCA) remain uncertain. MATERIALS AND METHODS: The methylation status of 27 candidate... -
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- CpG Island Methylator Phenotype-High Colorectal Cancers and Their Prognostic Implications and Relationships with the Serrated Neoplasia Pathway
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Rhee YY, Kim KJ, Kang GH
- KMID: 2412153
- Gut Liver.
- 2017 Jan;11(1):38-46.
- doi: 10.5009/gnl15535
The concept of a CpG island methylator phenotype (CIMP) was first introduced by Toyota and Issa to describe a subset of colorectal cancers (CRCs) with concurrent hypermethylation of multiple CpG... -
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- Correlation of Immunohistochemical Markers and BRAF Mutation Status with Histological Variants of Papillary Thyroid Carcinoma in the Korean Population
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Min HS, Lee C, Jung KC
- KMID: 1786960
- J Korean Med Sci.
- 2013 Apr;28(4):534-541.
- doi: 10.3346/jkms.2013.28.4.534
Several pathologic characteristics are associated with an adverse clinical outcome in papillary thyroid carcinoma (PTC), including the histological variant. This study aimed to investigate immunohistochemical expression and BRAF mutation status... -
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- B-RafV600E inhibits sodium iodide symporter expression via regulation of DNA methyltransferase 1
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Choi YW, Kim HJ, Kim YH, Park SH, Chwae YJ, Lee J, Soh EY, Kim JH, Park TJ
- KMID: 2155385
- Exp Mol Med.
- 2014 Nov;46(11):e120.
- doi: 10.1038/emm.2014.68
B-RafV600E mutant is found in 40-70% of papillary thyroid carcinoma (PTC) and has an important role in the pathogenesis of PTC. The sodium iodide symporter (NIS) is an integral plasma... -
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- Clinicopathological Features of Rare BRAF Mutations in Korean Thyroid Cancer Patients
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Cho U, Oh WJ, Bae JS, Lee S, Lee YS, Park GS, Lee YS, Jung CK
- KMID: 2129598
- J Korean Med Sci.
- 2014 Aug;29(8):1054-1060.
- doi: 10.3346/jkms.2014.29.8.1054
The most common BRAF mutation in thyroid cancer is c.1799T>A (p.Val600Glu), and other BRAF mutations are rarely reported. We investigated the clinicopathological features of thyroid cancer with rare BRAF mutations.... -
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- Evaluation of the Anyplex BRAF V600E Real-Time Detection Assay Using Dual-Priming Oligonucleotide Technology in Fine-Needle Aspirates of Thyroid Nodules
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Choi R, Park KS, Kim JW, Ki CS
- KMID: 2363266
- Ann Lab Med.
- 2015 Nov;35(6):624-629.
- doi: 10.3343/alm.2015.35.6.624
BACKGROUND: Several molecular assays have been developed to detect the BRAF V600E mutation in fine needle aspirates (FNAs) for the diagnosis of papillary thyroid cancer. Using a multiplex PCR technique,... -
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- Detection of Plasma BRAF(V600E) Mutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas
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Kim BH, Kim IJ, Lee BJ, Lee JC, Kim IS, Kim SJ, Kim WJ, Jeon YK, Kim SS, Kim YK
- KMID: 2450335
- Yonsei Med J.
- 2015 May;56(3):634-640.
- doi: 10.3349/ymj.2015.56.3.634
PURPOSE: The BRAF(V600E) mutation represents a novel indicator of the progression and aggressiveness of papillary thyroid carcinoma (PTC). The purpose of this study was to determine the clinical significance of... -
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- Mutational Analysis of KRAS, BRAF, and TP53 Genes of Ovarian Serous Carcinomas in Korean Women
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Cho YH, Kim DY, Kim JH, Kim YM, Kim KR, Nam JH, Kim YT
- KMID: 2396071
- Yonsei Med J.
- 2009 Apr;50(2):266-272.
PURPOSE: To assess the prevalence of KRAS, BRAF, and TP53 mutations in cases of low-grade and high-grade serous carcinomas and to evaluate the clinical outcomes of these morphologically distinct carcinomas.... -
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- The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells
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Kim WG, Choi HJ, Kim TY, Shong YK, Kim WB
- KMID: 2070111
- Korean J Intern Med.
- 2014 Jul;29(4):474-481.
BACKGROUND/AIMS: 5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a cellular energy sensor that monitors intracellular AMP/adenosine triphosphate (ATP) ratios and is a key regulator of the proliferation and survival of... -
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