- Stimulation of macrophage function by interphotoreceptor retinoid-binding protein: production of nitric oxide
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Bae SR
- KMID: 1127504
- Korean J Ophthalmol.
- 1999 Dec;13(2):57-64.
- doi: 10.3341/kjo.1999.13.2.57
In this study, we investigated whether retinal soluble proteins, such as interphotoreceptor retinoid-binding protein(IRBP), play a role in the induction of nitric oxide by macrophages in vitro. Cells from the... -
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- Stimulation of macrophage function by S-antigen: production of nitric oxide
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Bae SR
- KMID: 754267
- Korean J Ophthalmol.
- 2000 Jun;14(1):12-19.
- doi: 10.3341/kjo.2000.14.1.12
In this study, we investigated whether retinal soluble proteins, such as S-antigen, play a role in the induction of nitric oxide by macrophages in vitro. Cells from the murine macrophage... -
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- Nidogen Plays a Role in the Regenerative Axon Growth of Adult Sensory Neurons Through Schwann Cells
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Lee HK, Seo IA, Suh DJ, Park HT
- KMID: 1779199
- J Korean Med Sci.
- 2009 Aug;24(4):654-659.
- doi: 10.3346/jkms.2009.24.4.654
We previously reported that nidogen is an extracellular matrix protein regulating Schwann cell proliferation and migration. Since Schwann cells play a critical role in peripheral nerve regeneration, nidogen may play... -
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- Partial purification and characterization of a novel murine factor that augments the expression of class I MHC antigens on tumor cells
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Puri N, Saxena RK
- KMID: 754994
- Exp Mol Med.
- 1998 Jun;30(2):93-99.
A soluble factor which augments the expression of major histocompatibility complex class I (MHC I) antigens on a number of murine tumor cell lines, has been isolated from the culture supernatants of... -
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- Purification and characterization of recombinant murine endostatin in E. coli
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You WK, So SH, Lee H, Park SY, Yoon MR, Chang SI, Kim HK, Joe YA, Hong YK, Chung SI
- KMID: 1029927
- Exp Mol Med.
- 1999 Dec;31(4):197-202.
Endostatin, a carboxyl-terminal fragment of collagen XVIII is known as an anti-angiogenic agent, that specifically inhibits the proliferation of endothelial cell and the growth of several primary tumor.... -
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- Macrophage colony-stimulating factor promotes the survival of osteoclast precursors by up-regulating Bcl-XL
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Woo KM, Kim HM, Ko JS
- KMID: 755205
- Exp Mol Med.
- 2002 Nov;34(5):340-346.
Macrophage colony-stimulating factor (M-CSF) is known as one of the factors essential for osteoclast development. In the present study, we examined effects of M-CSF on the apoptotic pathway of osteoclast... -
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- The inhibitory effects of recombinant plasminogen kringle 1-3 on the neovascularization of rabbit cornea induced by angiogenin, bFGF, and VEGF
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Kim JH, Kim JC, Shin SH, Chang SI, Lee HS, Chung SI
- KMID: 1029928
- Exp Mol Med.
- 1999 Dec;31(4):203-209.
Angiostatin is a potent angiogenesis inhibitor that is composed of the first four kringles of plasminogen fragment. Angiostatin with one less kringle molecule (kringle 1 to 3) was... -
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- Interaction of TGF-beta1 and rhBMP-2 on Human Bone Marrow Stromal Cells Cultured in Collagen Gel Matrix
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Kim MK, Niyibizi C
- KMID: 720631
- Yonsei Med J.
- 2001 Jun;42(3):338-344.
- doi: 10.3349/ymj.2001.42.3.338
Transforming growth factor-beta1 (TGF-beta1) and bone morphogenetic protein-2 (BMP-2) are abundant proteins in the bone matrix. However, their interaction in controlling osteoblast differentiation is not clearly understood. In this study,... -
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- Expression of Th1 and Th2 type cytokines responding to HBsAg and HBxAg in chronic hepatitis B patients
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Lee M, Lee MA, Lee SK, Son M, Cho SW, Park S, Kim HI
- KMID: 648077
- J Korean Med Sci.
- 1999 Apr;14(2):175-181.
- doi: 10.3346/jkms.1999.14.2.175
The cytokine pattern on viral antigen recognition is believed to exert a profound influence on the resolution of viral infections and viral clearance. This study was initiated to investigate whether... -
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- Biologic Response of Degenerative Living Human Nucleus Pulposus Cells to Treatment with Cytokines
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Kim SH, Kuh SU, Kim KN, Park JY, Cho KH, Chin DK, Kim KS, Cho YE
- KMID: 2352817
- Yonsei Med J.
- 2015 Jan;56(1):277-286.
- doi: 10.3349/ymj.2015.56.1.277
PURPOSE: To investigate the molecular responses of various genes and proteins related to disc degeneration upon treatment with cytokines that affect disc-cell proliferation and phenotype in living human intervertebral discs... -
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- Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration
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Sung HJ, Kim YS, Kang H, Ko J
- KMID: 756335
- Exp Mol Med.
- 2008 Jun;40(3):332-338.
- doi: 10.3858/emm.2008.40.3.332
Chemokines and chemokine receptors play a role in migration of circulating leukocytes to the region of inflammation. Human LZIP is an uncharacterized transcription factor and is known to participate in... -
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- Early Sustained Injections of Erythropoietin Improve Angiogenesis and Restoration of Perfusion in the Ischemic Mouse Hindlimb
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Ahn S, Min SK, Min SI, Suh JH, Kim SJ, Ha J
- KMID: 1782142
- J Korean Med Sci.
- 2012 Sep;27(9):1073-1078.
- doi: 10.3346/jkms.2012.27.9.1073
This study was conducted to investigate the effects of erythropoietin (Epo) on both acute and chronic limb ischemia (ALI and CLI) and to evaluate the differences in mechanisms according to... -
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- Neurotoxicity Screening in a Multipotent Neural Stem Cell Line Established from the Mouse Brain
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Choi YS, Lee MC, Kim HS, Lee KH, Park YG, Kim HK, Jeong HS, Kim MK, Woo YJ, Kim SU, Ryu JK, Choi HB
- KMID: 1778041
- J Korean Med Sci.
- 2010 Mar;25(3):440-448.
- doi: 10.3346/jkms.2010.25.3.440
Neural stem cells (NSCs) have mainly been applied to neurodegeneration in some medically intractable neurologic diseases. In this study, we established a novel NSC line and investigated the cytotoxic responses... -
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- The Effects of Recombinant Human BMP-7, Prepared from a COS-7 Expression System, on the Proliferation and Differentiation of Rat Newborn Calvarial Osteoblasts
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Lee DH, Suh H, Han DW, Park BJ, Lee JW, Park JC
- KMID: 720897
- Yonsei Med J.
- 2003 Aug;44(4):593-601.
- doi: 10.3349/ymj.2003.44.4.593
A family of proteins, the bone morphogenetic proteins (BMPs), which promote osteoblast differentiation and bone mineralization, have recently been identified. One, BMP-7, has shown the ability to induce cartilage and... -
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- Blockade of VEGFR-1 and VEGFR-2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells
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Hwang JE, Lee JH, Park MR, Kim DE, Bae WK, Shim HJ, Cho SH, Chung IJ
- KMID: 1503899
- Yonsei Med J.
- 2013 Mar;54(2):374-380.
- doi: 10.3349/ymj.2013.54.2.374
PURPOSE: Hypoxia-inducible factor-1alpha (HIF-1alpha) increases transcription of the vascular endothelial growth factor (VEGF) gene. Inhibition of VEGF abolishes VEGF mediated induction of HIF-1alpha. Recent reports suggested that HIF-1alpha also mediated... -
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- The impact of pegylated interferon and ribavirin combination treatment on lipid metabolism and insulin resistance in chronic hepatitis C patients
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Jung HJ, Kim YS, Kim SG, Lee YN, Jeong SW, Jang JY, Lee SH, Kim HS, Kim BS
- KMID: 1737597
- Clin Mol Hepatol.
- 2014 Mar;20(1):38-46.
- doi: 10.3350/cmh.2014.20.1.38
BACKGROUND/AIMS: Lipid profile and insulin resistance (IR) are associated with hepatitis C virus (HCV) and may predict the chronic hepatitis C (CHC) treatment response. The aim of this study was... -
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- Combined Administration of Glutamine and Growth Hormone Synergistically Reduces Bacterial Translocation in Sepsis
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Jung SE, Youn YK, Lim YS, Song HG, Rhee JE, Suh GJ
- KMID: 1099787
- J Korean Med Sci.
- 2003 Feb;18(1):17-22.
- doi: 10.3346/jkms.2003.18.1.17
We investigated the combined effect of glutamine (GLN) and growth hormone (GH) on bacterial translocation (BT) in sepsis. After single intraperitoneal injection of lipopolysaccharide (10 mg/kg), 48 rats were divided... -
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- Excretory-secretory product of Paragonimus westermani newly excysted metacercariae inhibits superoxide production of granulocytes stimulated with IgG
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Shin MH
- KMID: 1715244
- Korean J Parasitol.
- 2000 Jun;38(2):103-106.
- doi: 10.3347/kjp.2000.38.2.103
It is well known that the cysteine proteases in excretory-secretory product (ESP) of Paragonimus westermani newly excysted metacercariae (PwNEM) are capable of degrading IgG in vitro. Recent evidence suggests that... -
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- Theophylline Increases the Uptake of Radioiodine by Mouse Thyroid
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Lee JM, Caturegli , Ladenson P
- KMID: 1733513
- J Korean Med Sci.
- 2004 Oct;19(5):704-709.
- doi: 10.3346/jkms.2004.19.5.704
Diagnostic and therapeutic use of radioiodine in the management of thyroid disorders depends on the ability of thyroid cells to concentrate radioiodine, a process that is regulated by the intracellular... -
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- Reactive oxygen species regulate the generation of urokinase plasminogen activator in human hepatoma cells via MAPK pathways after treatment with hepatocyte growth factor
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Lee KH, Kim JR
- KMID: 1123465
- Exp Mol Med.
- 2009 Mar;41(3):180-188.
- doi: 10.3858/emm.2009.41.3.021
Tumor cells are known to produce larger amounts of reactive oxygen species (ROS) than normal cells. Although numerous reports have indicated the importance of ROS in urokinase plasminogen activator (uPA)... -
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