- Expression of p53 protein in rheumatoid arthritis synovium. An immunohistochemical analysis
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Lee YH, Ji JD, Kim A, Kim CH, Song GG
- KMID: 759085
- Korean J Intern Med.
- 1999 Jan;14(1):59-65.
OBJECTIVES: Mutation of p53 may play a role in manifestation of rheumatoid arthritis synovium, but several studies on p53 expression in synovial tissues of rheumatoid arthritis showed conflicting... -
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- Increased serum levels of mutant p53 proteins in patients with colorectal cancer
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Shim KS, Kim KH, Park BW, Lee SY, Choi JH, Han WS, Park EB
- KMID: 1107225
- J Korean Med Sci.
- 1998 Feb;13(1):44-48.
- doi: 10.3346/jkms.1998.13.1.44
We have examined the serum levels of the mutant p53 protein in patients with colorectal cancer preoperatively (n=50), and in patients with adenomatous polyp (n=13). Mutant p53 protein in patients... -
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- Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death
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Gong X, Wang M, Tashiro SI, Onodera S, Ikejima T
- KMID: 1110127
- Exp Mol Med.
- 2006 Aug;38(4):428-434.
A terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay was used to determine that apoptosis causes HeLa cell death induced by pseudolaric acid B. The c-Jun N-terminal kinase (JNK) inhibitor... -
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- Cell proliferation index and the expression of p53 and Bcl-2 in tumorous and non-tumorous lesions of hepatocellular carcinoma and metastatic liver cancer
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Yoon DS, Cheong JH, Park YN, Kwon SW, Chi HS, Kim BR
- KMID: 711579
- Yonsei Med J.
- 1998 Oct;39(5):424-429.
- doi: 10.3349/ymj.1998.39.5.424
In the development of a cancer, unlimited cell proliferation has been believed to play an important role. In addition, a programmed cell death called apoptosis, which is regulated by several... -
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- Prognostic Significance of p53, mTOR, c-Met, IGF-1R, and HSP70 Overexpression after the Resection of Hepatocellular Carcinoma
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Kang GH, Lee BS, Lee ES, Kim SH, Lee HY, Kang DY
- KMID: 1774532
- Gut Liver.
- 2014 Jan;8(1):79-87.
BACKGROUND/AIMS: The current study examines the expression of molecular biomarkers in hepatocellular carcinoma (HCC) and whether these findings correlate with the clinicopathologic features of the disease and patient survival. METHODS: We... -
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- Detection of Epstein-Barr Virus by PCR and Expression of LMP1, p53, CD44 in Gastric Cancer
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Lee MA, Hong YS, Kang JH, Lee KS, You JY, Lee KY, Park CH
- KMID: 759684
- Korean J Intern Med.
- 2004 Mar;19(1):43-47.
BACKGROUND: Epstein-Barr virus (EBV) is associated with various lymphoproliferative disorders and nasopharyngeal carcinoma. Recently, some gastric cancer cells were observed to contain the EBV sequence. We detected EBV in gastric... -
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- Mechanisms of Apoptosis on Human Lens Epithelium after Ultraviolet Light Exposure
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Kim ST, Koh JW
- KMID: 1010028
- Korean J Ophthalmol.
- 2011 Jun;25(3):196-201.
- doi: 10.3341/kjo.2011.25.3.196
PURPOSE: The purpose of this study is to understand the mechanism of apoptosis occurring on a cultured human lens epithelial cell line after exposure to ultraviolet (UV) light. We intended... -
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- Pro-apoptotic function of hepatitis B virus X protein
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Kim KH
- KMID: 1792589
- Korean J Hepatol.
- 2010 Jun;16(2):112-122.
- doi: 10.3350/kjhep.2010.16.2.112
Infection of hepatitis B virus (HBV) is a main cause of liver diseases including hepatitis, cirrhosis and hepatocellular carcinoma (HCC). Among the HBV-encoded proteins, the HBV X protein (HBx) has... -
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- Establishment of Hepatocellular Cancer Induced Pluripotent Stem Cells Using a Reprogramming Technique
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Kim HJ, Jeong J, Park S, Jin YW, Lee SS, Lee SB, Choi D
- KMID: 2412193
- Gut Liver.
- 2017 Mar;11(2):261-269.
- doi: 10.5009/gnl15389
BACKGROUND/AIMS: Cancer is known to be a disease by many factors. However, specific results of reprogramming by pluripotency-related transcription factors remain to be scarcely reported. Here, we verified potential effects... -
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- HPV E6 antisense induces apoptosis in CaSki cells via suppression of E6 splicing
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Cho CW, Poo H, Cho YS, Cho MC, Lee KA, Lee SJ, Park SN, Kim IK, Jung YK, Choe YK, Yeom YI, Choe IS, Yoon DY
- KMID: 1081466
- Exp Mol Med.
- 2002 May;34(2):159-166.
Cervical cancer is known to be highly associated with viral oncogene E6 and E7 of human papilloma virus. Down-regulation of oncogene expression by antisense-based gene therapy has been extensively studied.... -
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- Clinicopathological Significance of Maspin Expression in Breast Cancer
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Lee MJ, Suh CH, Li ZH
- KMID: 1781841
- J Korean Med Sci.
- 2006 Apr;21(2):309-314.
- doi: 10.3346/jkms.2006.21.2.309
Maspin is a unique serine proteinase inhibitor that has tumor suppressor activity. It has been reported that maspin is expressed in normal human mammary epithelial cells and it is down-regulated... -
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- Changes in expression of cell cycle regulators after G1 progression upon repetitive thioacetamide treatment in rat liver
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Hong SH, Lee GD, Chung JY, Cho KS, Park SH, Kim IH, Jeong JS
- KMID: 755208
- Exp Mol Med.
- 2002 Nov;34(5):361-366.
Repetitive low dose thioacetamide (TA) treatment of hepatocytes was found to induce cells in G2 arrest. In the present study, an attempt was made to investigate alterations in expression of... -
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- Carcinoma ex Pleomorphic Adenoma of the Salivary Glands: Distinct Clinicopathologic Features and Immunoprofiles Between Subgroups According to Cellular Differentiation
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Kim JW, Kwon GY, Roh JL, Choi SH, Nam SY, Kim SY, Cho KJ
- KMID: 1785983
- J Korean Med Sci.
- 2011 Oct;26(10):1277-1285.
- doi: 10.3346/jkms.2011.26.10.1277
In carcinoma ex pleomorphic adenoma (CXPA), pleomorphic adenoma (PA) and diverse carcinoma components showing luminal (ductal) or non-luminal (myoepithelial) differentiation coexist. To elucidate the clinicopathological implications of cellular differentiation in... -
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- The Bacterial Protein Azurin Enhances Sensitivity of Oral Squamous Carcinoma Cells to Anticancer Drugs
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Choi JH, Lee MH, Cho YJ, Park BS, Kim S, Kim GC
- KMID: 1108070
- Yonsei Med J.
- 2011 Sep;52(5):773-778.
- doi: 10.3349/ymj.2011.52.5.773
PURPOSE: Surgical therapy is the primary treatment for oral cancer, but it can cause facial distortion. Therefore, if anticancer drugs are effective against oral cancer, they may be used preferentially.... -
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- Anthocyanin Induces Apoptosis of DU-145 Cells In Vitro and Inhibits Xenograft Growth of Prostate Cancer
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Ha US, Bae WJ, Kim SJ, Yoon BI, Hong SH, Lee JY, Hwang TK, Hwang SY, Wang Z, Kim SW
- KMID: 2352784
- Yonsei Med J.
- 2015 Jan;56(1):16-23.
- doi: 10.3349/ymj.2015.56.1.16
PURPOSE: To investigate the effects of anthocyanins extracted from black soybean, which have antioxidant activity, on apoptosis in vitro (in hormone refractory prostate cancer cells) and on tumor growth in... -
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- Sonography of Invasive Apocrine Carcinoma of the Breast in Five Cases
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Seo KJ, An YY, Whang IY, Chang ED, Kang BJ, Kim SH, Park CS, Kim JS, Hong H
- KMID: 2160767
- Korean J Radiol.
- 2015 Oct;16(5):1006-1011.
- doi: 10.3348/kjr.2015.16.5.1006
OBJECTIVE: To evaluate the sonographic features of invasive apocrine carcinoma (IAC) of the breast. MATERIALS AND METHODS: This study included five pathologically proven cases of IAC, and their sonographic features were... -
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- Expression of Beta-catenin and E-cadherin in Early Gastric Cancer: Correlation with Clinicopathologic Parameters
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Song BJ, Park YJ, Kim HS, Kim CN, Chang SH
- KMID: 772610
- Korean J Gastroenterol.
- 2004 Feb;43(2):82-89.
BACKGROUND/AIMS: Beta-catenin is known to perform two unrelated functions in cadherin-mediated cell to cell adhesion system and Wnt pathway. Recent studies reported cytoplasmic and nuclear accumulation of beta-catenin by... -
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- Effects of Chromosomal Polyploidy on Survival of Colon Cancer Cells
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Park SU, Choi ES, Jang YS, Hong SH, Kim IH, Chang DK
- KMID: 1128353
- Korean J Gastroenterol.
- 2011 Mar;57(3):150-157.
- doi: 10.4166/kjg.2011.57.3.150
BACKGROUND/AIMS: Tetraploid cells are frequently observed in the inflamed mucosal epithelial cells of the patients with Barrett's esophagus or chronic ulcerative colitis. Polyploidy often occurs during cell fusion, abortive cell... -
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- The Role of Microsatellite Instability at Chromosome 11p15.5 in the Progression of Breast Ductal Carcinoma
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Kim DJ, Park JY, Lee MH, Sohn YK
- KMID: 1733512
- J Korean Med Sci.
- 2004 Oct;19(5):698-703.
- doi: 10.3346/jkms.2004.19.5.698
The study of microsatellite instability (MSI) has provided the evidence to support asequential, progressive pathway for the development of cancer. In this study, we analyzed the role of MSI at... -
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- American Ginseng Transcriptionally Activates p21 mRNA in Breast Cancer Cell Lines
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Duda RB, Kang SS, Archer SY, Meng S, Hodin RA
- KMID: 1721175
- J Korean Med Sci.
- 2001 Dec;16(Suppl):S54-S60.
- doi: 10.3346/jkms.2001.16.S.S54
American ginseng (AG) has been demonstrated to inhibit breast cancer cell growth in vitro. p21 protein, a universal cell cycle inhibitor, binds cyclin-CDK complexes, an important mechanism in cell cycle... -
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